Prevalence of Helicobacter pylori infection in advanced gastric carcinoma

Araújo‐Filho, Irami; Brandão-Neto, José; Pinheiro, Laíza Araújo Mohana; Azevedo, Ítalo Medeiros; Freire, Flávio Henrique Miranda de Araújo; Medeiros, Aldo Cunha

doi:10.1590/s0004-28032006000400009

Cited by 15 publications

(7 citation statements)

References 48 publications

(53 reference statements)

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“…This study was conducted in an area with high prevalence of HP infection, around 65% (9) . Interestingly, other series showed a higher prevalence of HP infection and gastric cancer compared to our patients ( Figure 1) and other series of gastric cancer in Brazil (1) . Differences in HP strains may explain this finding and the lack of difference in survival found in our series.…”

Section: Discussionsupporting

confidence: 51%

Helicobacter pylorihas no influence on distal gastric cancer survival

Santos

Lourenço

Herbella

et al. 2011

Arq. Gastroenterol.

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-Context -There is some evidence that Helicobacter pylori correlates with distal gastric cancer genesis. However, few studies analyzed the survival related to H. pylori infection. Objective -To correlate gastric cancer survival and H. pylori infection. Methods -Sixty-eight patients with distal gastric cancer that underwent subtotal gastrectomy were studied. Minimal follow-up was 1 month. H. pylori infection was confirmed by biopsy. Results -Thirty-four patients (19 males (55.9%), mean age 60.9 ± 14.03, range 33-82 years) were H. pylori positive. Thirty-four patients (16 males (47.1%), mean age 57.9 ± 13.97, range 27-85 years) were H. pylori negative. Groups were comparable in regards to age (P = 0.4), gender (P = 0.5), stage [T (P = 0.2), N (P = 0.6) and M (P = 0.

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Section: Discussionsupporting

confidence: 51%

Helicobacter pylorihas no influence on distal gastric cancer survival

Santos

Lourenço

Herbella

et al. 2011

Arq. Gastroenterol.

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“…CagA, a cytotoxin produced by H. pylori, is a marker of bacterial virulence and is associated with gastric disorders such as peptic ulcer and gastric carcinoma in western countries (20,22) . A high incidence of gastric carcinoma and peptic ulcer, as well as a high prevalence of H. pylori infection, is observed in Brazil, particularly in the state of Pará (1,13,27) . The frequency of the cagA gene observed in the patients studied here was higher than that reported in other studies conducted in different Brazilian states (4,23) .…”

Section: Discussionmentioning

confidence: 99%

Role of Helicobacter Pylori Infection and Lifestyle Habits in the Development of Gastroduodenal Diseases in a Population From the Brazilian Amazon

Vinagre

VILAR-e-SILVA

Fecury

et al. 2013

Arq. Gastroenterol.

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-Context -Although more than half of the world's population is colonized with Helicobacter pylori, it remains unknown why this organism is able to produce severe disease in some hosts and be innocuous in others. The clinical outcome of infection is determined by several factors, including differences in the host response to bacterial stimulation, specific virulence factors of the organism and environmental influences, or a combination of these factors. Objectives -This study compared the prevalence of H. pylori infection and risk factors (infection with CagA+ strains, excessive alcohol consumption, smoking, and inadequate eating habits) between patients with different gastrointestinal disorders and associated these risk factors with the histopathological findings.Methods -In a prospective study, samples were collected from 442 patients and a standardized questionnaire regarding lifestyle habits (excessive alcohol consumption, smoking, and eating habits) was applied. The presence of H. pylori and of the cagA gene was investigated by polymerase chain reaction (PCR). Gastric biopsies were obtained for histological assessment. Results -The frequency of alcohol consumption, smoking, inadequate diet and infection with CagA+ H. pylori was higher among patients with peptic ulcer and adenocarcinoma when compared to those with gastritis. Gastric inflammation was more pronounced in patients infected with CagA+ strains. Conclusion -We conclude that infection with CagA+ H. pylori strains, excessive alcohol consumption, smoking and inadequate eating habits increase the risk of developing peptic ulcer and gastric carcinoma.

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“…However, most of these have used serology and histology to detect H. pylori infection. [34][35][36] The cagE gene was found in 53.2% of H. pylori-positive gastric cancer cases. This is the first study to analyze the frequency of cagE in gastric cancer separately.…”

Section: Discussionmentioning

confidence: 99%