The relationship between Helicobacter pylori genes cagE and virB11 and gastric cancer

Lima, Vilma; Lima, Marcos Antônio Pereira de; Ferreira, Márcia Valéria Pitombeira; Barros, Marcos Aurélio Pessoa; Rabenhorst, Sílvia Helena Barem

doi:10.1016/j.ijid.2009.09.006

Cited by 24 publications

(21 citation statements)

References 43 publications

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“…The cag E gene is one of the components in cag PAI 43 and is involved in the construction of the bacterial transport system 44 and induces IL‐8 production in gastric epithelial cells 43 . As with the presence of the cag A gene observed in this study, it was found that the cag E gene in patients with CCA was significantly higher than in those with cholelithiasis ( P < 0.05), which is in accord with a previous report on the cag E gene and gastric cancer 45 . The combination of the cag A and cag E positive genes was significantly more prevalent among patients with CCA than in those with cholelithiasis ( P < 0.05).…”

Section: Discussionsupporting

confidence: 92%

“…43 As with the presence of the cagA gene observed in this study, it was found that the cagE gene in patients with CCA was significantly higher than in those with cholelithiasis (P < 0.05), which is in accord with a previous report on the cagE gene and gastric cancer. 45 The combination of the cagA and cagE positive genes was significantly more prevalent among patients with CCA than in those with cholelithiasis (P < 0.05). The present results show that the presence of the cagE gene is commonly found with the cagA gene, which is a representation of cagPAI.…”

Section: Discussionmentioning

confidence: 92%

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Molecular analysis of Helicobacter pylori virulent-associated genes in hepatobiliary patients

Boonyanugomol

Chomvarin

Sripa

et al. 2012

HPB

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 92%

Molecular analysis of Helicobacter pylori virulent-associated genes in hepatobiliary patients

Boonyanugomol

Chomvarin

Sripa

et al. 2012

HPB

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“…In Brazil, cagA and cagE genes have been detected more often in strains from peptic ulcer patients compared with nonulcer subjects, and the cagE gene has exhibited an association with gastric cancer (Proença Módena et al 2007;Lima et al 2010). Conversely, in East Asia, e.g., in Japan, almost all ([96%) H. pylori strains have been cagE ?…”

Section: Introductionmentioning

confidence: 99%

Benefits of Helicobacter pylori cagE genotyping in addition to cagA genotyping: a Bulgarian study

Boyanova

Yordanov

Gergova

et al. 2011

Antonie van Leeuwenhoek

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Associations of Helicobacter pylori cagE status with complex patient characteristics remain to be elucidated in Eastern Europe. The aim of this study was to assess the frequencies of cagE gene and cagA/cagE combinations in H. pylori strains from symptomatic Bulgarian patients and to improve cagA detection. cagA and cagE genotypes were evaluated in 219 patients with single-strain infections. In total, 84.9% of strains were cagA (+), while 68.5% were cagE (+). cagA (+), cagE (+), and cagA (+)/cagE (+) strains were more prevalent in peptic ulcer (93.8%, 84.4%, and 84.4%) compared with nonulcer patients (81.3%, 61.9%, and 61.3%, respectively). In elderly patients, cagE (+) and cagA (+)/cagE (+) strains were 1.9-fold more common than in the 12 children evaluated. Only 10% of the elderly subjects harbored low-virulence cagA (+)/cagE (-) strains compared with 16.8% of adults and 41.7% of children. Intriguingly, prevalence of the cagA (+)/cagE (-) genotype was 2.1-fold lower in men than in women, suggesting a higher frequency of more virulent strains in men. The presence of both cag genes and combinations was not linked to strain susceptibility to clarithromycin or metronidazole, place of residence, or prior therapy. Use of an extra primer pair increased cagA detection in 14.7% of 31 cagA (-) strains. In conclusion, use of a second primer pair for the cagA gene can be recommended in countries with common cagA (+) strains. Although both cag genes were linked to severe diseases in Bulgarian patients, the best discrimination of virulent strains was obtained by the cagA/cagE combination or by the cagE gene alone. cagE prevalence increased gradually with patient age, while the cagA (+)/cagE (-) genotype, implying a disrupted cag pathogenicity island, was associated with both younger age and female gender.

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“…[20][21][22] The prevalence range (50-86%) of cagA detection in different regions demonstrate a dominance of circulating cagA positive H. pylori strains, and its presence is commonly associated with the development of severe gastroduodenal damage, including gastric diseases and cancer. 23,24 By analyzing the H. pylori detection profile we found a significant OR value of 10.66, when positive profile of all genes was compared with negative profile between urban and rural population ( Table 2). This indicates that the difference for H. pylori infection in the rural population is due at low number of negative patients in relation to urban.…”

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confidence: 98%

Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela

Contreras

Fernández-Delgado

Reyes

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. The goal of this work was to assess the Helicobacter pylori prevalence in a rural mestizo population and compare it to an urban population from Venezuela. The study was performed in gastric juice samples of 71 dyspeptic patients from Caracas (urban) and 39 from Tucupita (rural), in the Orinoco Delta region. Helicobacter pylori was detected by amplification of 16S rRNA, glmM, and ureA genes in 55.0% patients from urban and 87.2% from rural populations. cagA was found positive in 51% and 62% urban and rural patients, respectively. Non-H. pylori Helicobacter species were not detected in the urban population, but was found in 7.7% of patients in the rural study site. Frequency values of the 16S rRNA, glmM, and ureA genes were higher in the rural population. The odds ratio for each gene was 15.18 for 16S rRNA, 2.34 for glmM, 2.89 for ureA, and 1.53 cagA, showing significant differences except for cagA when gene frequency was compared in both populations. These results demonstrate a higher frequency of H. pylori and gastric non-H. pylori Helicobacter infection in a rural mestizo population with low hygienic standards as compared with city dwellers, representing a potential risk for the development of gastroduodenal diseases.

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The relationship between Helicobacter pylori genes cagE and virB11 and gastric cancer

Cited by 24 publications

References 43 publications

Molecular analysis of Helicobacter pylori virulent-associated genes in hepatobiliary patients

Molecular analysis of Helicobacter pylori virulent-associated genes in hepatobiliary patients

Benefits of Helicobacter pylori cagE genotyping in addition to cagA genotyping: a Bulgarian study

Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela

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