Metano no ar expirado de crianças com constipação crônica funcional

Soares, Ana Cristina Fontenele; Tahan, Soraia; Fagundes-Neto, Ulysses; Morais, Mauro Batista de

doi:10.1590/s0004-28032002000100012

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…M. smithii was evaluated on fecal microbiota through molecular methods only in France [ 6 , 22 ] and New Zealand [ 7 ]; this is the first study in Brazil evaluating the presence of M. smithii on pediatric populations with different socioeconomic conditions. The studies in Brazil have used only the dosage of breath CH 4 as an indirect marker for the presence of methanogenic archaea in children with severe chronic constipation in a specialized outpatient clinic of pediatric gastroenterology [ 12 , 13 ] and children living in different environmental conditions [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have associated breath methane excretion with colorectal cancer [ 9 ], irritable bowel syndrome [ 10 ], diverticulosis [ 11 ], and chronic constipation with retentive fecal incontinence [ 12 , 13 ]. However, the exact role of M. smithii in the development or outcome of these illnesses has not yet been established [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the pediatric population, the presence of M. smithii in gut microbiota has not been carefully examined. There is little information about CH 4 production, which is found almost exclusively in children with fecal retentive incontinence secondary to chronic constipation [ 12 , 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Children Living near a Sanitary Landfill Have Increased Breath Methane andMethanobrevibacter smithiiin Their Intestinal Microbiota

Filho

Carmo-Rodrigues

Mello

et al. 2014

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This study evaluated the breath CH4 excretion and concentration of M. smithii in intestinal microbiota of schoolchildren from 2 slums. One hundred and eleven children from a slum near a sanitary landfill, 35 children of a slum located away from the sanitary landfill, and 32 children from a high socioeconomic level school were included in the study. Real-time PCR was performed to quantify the M. smithii nifH gene and it was present in the microbiota of all the participating children, with higher (P < 0.05) concentrations in those who lived in the slum near the landfill (3.16 × 107 CFU/g of feces), comparing with the children from the slum away from the landfill (2.05 × 106 CFU/g of feces) and those from the high socioeconomic level group (3.93 × 105 CFU/g of feces). The prevalence of children who present breath methane was 53% in the slum near the landfill, 31% in the slum further away from the landfill and, 22% in the high socioeconomic level group. To live near a landfill is associated with higher concentrations of M. smithii in intestinal microbiota, comparing with those who live away from the landfill, regardless of their socioeconomics conditions.

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