CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

Mandorwski, Sandra; Lourenço, Laércio Gomes; Forones, Nora Manoukian

doi:10.1590/s0004-28032002000100004

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…The positive rates of CEA, CA19-9, CA24-2, and CA72-4 were strongly related to TNM staging, consistent with other studies (Safi et al, 1995;Marrelli et al, 1999;Ychou et al, 2000;Carpelan et al, 2002;Mandorwski et al, 2002;Mandorwski et al, 2002;Jing et al, 2013), and the levels of these TMs increased according to the progression of the tumor. Other study reported that no correlation exists between CEA, CA19-9 and tumor stage (Hee et al, 2014).…”

Section: 10267 Tumor Markers For Diagnosis Monitoring Of Recurrencesupporting

confidence: 89%

Tumor Markers for Diagnosis, Monitoring of Recurrence and Prognosis in Patients with Upper Gastrointestinal Tract Cancer

Jing

Wang²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: 10267 Tumor Markers For Diagnosis Monitoring Of Recurrencesupporting

confidence: 89%

Tumor Markers for Diagnosis, Monitoring of Recurrence and Prognosis in Patients with Upper Gastrointestinal Tract Cancer

Jing

Wang²,

Xu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Production of tumor markers by neoplasic cells present in the peritoneal cavity is considered the determining factor for levels in the peritoneal washing. Such levels depend on the number of cells present in the peritoneal cavity as well as their capacity to produce the marker (1,3,17,23,29,35) . Thus, raised serum levels of the tumor marker may be the result of increased production within the peritoneal cavity which, in turn, results in higher peritoneal and serum levels.…”

Section: Resultsmentioning

confidence: 99%

“…Less raised levels of CA72-4 in a patient may indicate the presence of few cells in the peritoneal cavity, resulting in the possibility of longer survival times than in patients with higher peritoneal levels of CA72-4. On the other hand, less raised levels of CA72-4 could reflect differences in CA72-4 marker producing capacity of neoplasic cells in the peritoneal cavity (3,23,29) . This raises the question as to whether findings of high peritoneal levels of CA72-4 necessarily imply the presence of neoplasic cells in the cavity.…”

Section: Resultsmentioning

confidence: 99%

“…lymphonodal micrometastases, number some of these possible routes. This possibility is partially supported by the fact that peritoneal recurrence takes place in around 1% of patients with early gastric carcinoma (1,17,23,29,35) . Although CA72-4 marker secretion by the gastric neoplasia depends, among other factors, on lesion volume and vascularity as well as patient immunity, levels of CA72-4 in the peritoneum and serum are considered closely related (17,29,35) .…”

Section: -Jul/set 2007mentioning

confidence: 98%

“…This event may allow provision of more accurate adjunct treatment and post-operative follow up. To date however, few studies have addressed this issue (3,17,23,29) . The objective of this study was to analyze the relationship between levels of tumor marker CA72-4 in the serum and peritoneal washing of patients operated on gastric carcinoma, along with morphological aspects of the neoplasia.…”

Section: Introductionmentioning

confidence: 99%

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CA72-4 antigen levels in serum and peritoneal washing in gastric cancer: correlation with morphological aspects of neoplasia

Fernandes¹,

Martins²,

Nagashima

et al. 2007

Arq. Gastroenterol.

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-Background -Determining levels of tumor markers in peritoneal washing enables likelihood of peritoneal recurrence to be ascertained in patients with high marker levels, thereby allowing provision of more accurate adjuvant treatment and postoperative follow up. Aim -To analyze the relationship between levels of tumor marker CA72-4 in serum and peritoneal washing, and morphological aspects of gastric carcinoma. Method -This study analyzed 32 consecutively-operated patients with gastric carcinoma, who underwent subtotal, total or palliative gastrectomy. The variables studied were CA72-4 levels in serum and peritoneal washing, lesion site, stage, degree of cell differentiation, operation performed, and number of extirpated and involvement lymph nodes. Of the 32 patient sample, 21 (65.6%) were male and 11 (34.4%) female. Mean age was 62.6 ± 14.2 years (29 to 91 years). Following anesthetic induction, peripherical venous blood was collected through percutaneous punction of an upper limb vein. After the procedure, 50 mL of physiologic solution at 37ºC was introduced into the cul-de-sac. A 10 mL volume of this liquid was aspirated from the cavity and the peritoneal washing tested for CA72-4 levels. Normal values for CA72-4 levels in serum were considered ≤7 U/mL and high levels as >7U/mL, whilst for the peritoneal washing normal levels were ≤0.61 U/mL, and abnormal >0.61 U/mL. Results -Mean pre-operative serum levels for CA72-4 were 6.55 U/mL ± 15.30 (0.3 to 75.30 U/mL) whilst the mean level of CA72-4 in peritoneal washing was 8.50 U/mL ± 26.72 (0.3 to 142.00 U/mL); correlation between these levels was significant. Lymph nodes involvement by the gastric carcinoma correlated significantly with higher CA72-4 levels in both serum and peritoneal wash. There was no statistically significant correlation between serum level of CA72-4 and invasion into serosa by the gastric carcinoma. There was however, significant correlation between peritoneal washing levels of CA72-4 and involvement of serosa by gastric carcinoma. There was also a significant correlation between more advanced stages of gastric carcinoma and higher levels of CA72-4 in the peritoneal washing, although serum levels of CA72-4 and more advanced stage of gastric neoplasia showed no significant correlation. Degrees of cellular differentiation in the gastric carcinoma did not differ significantly with CA72-4 levels in serum or peritoneal washing. Conclusions -High levels of CA72-4 in peritoneal washing correlated significantly with lymph node metastasis and serosa involvement by the neoplasia, and also with more advanced stage of gastric carcinoma. The levels of CA72-4 in the blood correlated significantly with lymph node involvement by the gastric carcinoma, but not with serosa invasion or more advanced stage of neoplasia.

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