Estudo do esvaziamento gástrico e da distribuição intragástrica de uma dieta sólida através da cintilografia: diferenças entre os sexos

Abstract

Gender-related differences in gastric emptying are still controversial. The aims of this study were: to confirm the sex-related difference in gastric emptying of a solid meal and to investigate its association with different patterns of meal distribution between the proximal and distal gastric compartments. Eighteen healthy volunteers (nine males, mean age 35 +/- 9 years; nine females, mean age: 41 +/- 11 years) were studied in the morning, after ingestion of the solid test-meal (an omelette labeled with 185MBq of 99mTc-sulfur colloid). Simultaneous anterior and posterior images of the stomach were acquired immediately after ingestion of the meal and every 10 minutes for 120 minutes. Time versus activity curves were obtained for the whole, proximal and distal stomach. Gastric T1/2 was longer in women (96.1 +/- 17.2 min) than in men (79.9 +/- 17.8 min; P = 0.02). The analysis of the meal distribution inside the stomach showed no differences between males and females in proximal gastric emptying, but the meal retention in the distal compartment was significantly increased among women (P = 0.04). In conclusion, gastric emptying of a solid meal is slower in pre-menopausal women than in age-matched men, probably due to an increased retention of the meal in the distal compartment. This should be taken into consideration to avoid misleading diagnosis of gastroparesis for female patients.

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

“…Datz et al [18] also reported that healthy women empty both solids and liquids from their stomachs more slowly than men with a few examples using gastric emptying scintigraphy. Lorena et al [19] showed gastric emptying of a solid meal is slower in women than in age-matched men using gastric emptying scintigraphy. Our data confirmed that gastric emptying in healthy women is slower than in healthy men with the 13 C-acetate breath test.…”

Estudo do esvaziamento gástrico por cintilografia em pacientes com insuficiência renal crônica

“…In the group formed by patients, we tried to control the variables already mentioned in the literature. Although there are controversies, it seems gastric emptying is slower in women than men 11,12 , because feminine sexual hormones have an inhibitor role in gastric motility 13 . With menopause, this effect disappears and gastric emptying rates in both genders tend to be the same 14 .…”

“…The examinations were carried out according to the previously published technique 10,11 . The participants were studied in the morning after a fasting period of ten hours, at least.…”

Esvaziamento gástrico nos pacientes com insuficiência renal crônica submetidos à hemodiálise

“…Neste estudo procurou-se controlar as variáveis que 14 . Com a menopausa este efeito tenderia a desaparecer e as taxas de EG a se igualar 11 .…”

“…No estudo do esvaziamento gástrico os exames foram realizados de acordo com a técnica já publicada anteriormente 14 . Os participantes foram estudados pela manhã, após jejum de pelo menos 10 horas.…”