ASSOCIATIONS OF IL-6 -174G>C AND IL-10 -1082A>G POLYMORPHISMS WITH SUSCEPTIBILITY TO CELIAC DISEASE: EVIDENCE FROM A META-ANALYSIS AND LITERATURE REVIEW

Abstract

BACKGROUND: There has been little evidence to suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms are significantly associated with susceptibility to celiac disease. Thus, we performed the present meta-analysis to explore the potential association between these polymorphisms and celiac disease risk. METHODS: Eligible studies were searched in PubMed, Medline, Embase, Web of Science and CNKI database up to April 20, 2019. Odds ratios with 95% confidence interval were calculated to assess the potential associations. Moreover, we performed the heterogeneity, sensitivity, and publication bias tests to clarify and validate the pooled results. RESULTS: Overall, nine case-control studies involving five studies with 737 cases and 1,338 control on IL-6 -174G>C polymorphism and four studies with 923 cases and 864 controls on IL-10 -1082A>G polymorphism were selected. The pooled ORs showed that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms were not significantly associated with increased risk of celiac disease under all five genetic models. There was no publication bias. CONCLUSION: To the best of our knowledge, this is the first meta-analysis summarizing all of the available studies on the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease. Our results suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms may not be associated with increased risk of celiac disease. Moreover, large and well-designed studies are needed to fully describe the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease.

The expansion of CD14+ CD163+ subpopulation of monocytes and myeloid cells‐associated cytokine imbalance; candidate diagnostic biomarkers for celiac disease (CD)

“…We realized that IL-10 and TNFα expressions were noticeably elevated among patients, while TGFβ expression was markedly decreased. In accordance with our findings, the elevation of IL-10 has been also reported in previous studies by Forsberg et al 33,34 and Manavalan et al 35 Moreover, several IL-10 polymorphisms have been associated with the susceptibility to CD, 36,37 which highlights the importance of this multifunctional cytokine 38 in the immunopathogenesis of CD. In order to better understand the role of IL-10 in the pathogenesis of CD, Hollon et al 39 revealed that gliadin increased the secretion of IL-10 from intestinal biopsy explants of CD patients and individuals with non-celiac gluten sensitivity.…”

Alteration of interleukin-10-producing Type 1 regulatory cells in autoimmune diseases

“…A large body of evidence shows that IL-10 plays a key role in modulating inflammatory responses in the intestine of CD patients [67]. First, several groups described that IL-10 gene polymorphisms are linked to CD [68][69][70]. Second, increased levels of IL-10 and IFNg have been reported in IELs isolated from duodenal biopsies of untreated CD patients [71].…”

Association of IL-10-1082G > A, -819C > T and -592C > A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

“…The IL-10 promoter is highly polymorphic [17][18][19][20], and three single nucleotide polymorphisms (SNPs) at positions -1082G>A, -819C>T and -592C>A polymorphisms within the promoter region have been shown to correlate with IL-10 production (22,24,25). To date, several genetic epidemiology studies have assessed the association between IL-10 -1082G>A, -819C>T and -592C>A polymorphisms and pediatric asthma in different populations (26,27).…”

“…Human IL-10 has a broad-spectrum antiinflammatory activity which is expressed by activated monocytes/macrophages, natural killer (NK) cells, dendritic cells (DCs), mast cells, B cells, and regulatory T cell subsets (16). Moreover, IL-10 is known to have macrophage-deactivating properties and undermines the Th1-driven pro-inflammatory response by down-regulating the production of several cytokines (17,18). Human IL-10 gene maps to chromosome 1q31-32, contains four introns and five exons, and spans about 4.7 kb (19).…”