Chromoendoscopy Using Toluidine Blue Plus Lugol’s Solution for Early Diagnosis of Esophageal Premalignant Lesions and Superficial Neoplasms in High-Risk Patients

Piñerúa-Gonsálvez, Jean Félix; Zambrano-Infantino, Rosanna Del Carmen; Benítez, Sylvia

doi:10.1590/s0004-2803.201900000-01

Cited by 3 publications

(1 citation statement)

References 19 publications

(17 reference statements)

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“…For this reason, it would be desirable to have techniques that facilitate the visualization and detection of lesions to perform an exeresis with negative resection margins on the first treatment. In the last decade, toluidine blue staining has been used mainly for the detection of the oral cavity, oropharynx and esophagus premalignant and malignant lesions [ 18 , 19 , 20 , 21 ]. Toluidine blue is an acidophilic metachromatic dye that selectively stains acidic tissue components.…”

Section: Introductionmentioning

confidence: 99%

Early Glottic Cancer Treated by Transoral Laser Surgery Using Toluidine Blue for the Definition of the Surgical Margins: A Pilot Study

et al. 2020

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Background and objectives: Transoral laser microsurgery (TLM) is widely accepted for its advantages, which consist of a brief hospital stay, rapid functional recovery, low management costs and the fact that it can be easily repeated in cases of recurrence. However, a high incidence of positive or narrow surgical margins has been reported in the literature, even if controversy still exists on the prognostic significance of positive resection margins. The aim of the study was to evaluate the utility of toluidine blue staining in defining the resection margins of early glottic cancer (T1a–T2) treated with TLM. Materials and Methods: This retrospective study was conducted on patients with early glottic cancer (T1a–T2) managed by TLM. A group of patients treated between 2010 and 2014 underwent toluidine blue staining (TB group) of the lesions before starting the cordectomy by TLM, and a group of patients treated by TLM between 2006 and 2009 was considered the control group. Results: A total of 44 subjects were included in this study: 41 were men, and 3 were women. The mean age was 58 ± 9.0 years (median 59.0, range 41–77). Twenty-three of the 44 patients were included in the TB group and 21 in the case control group. In the TB group, only the positivity of the deep margin was a predictor of local recurrence (p = 0.037), while in the control group, positive or close margins and the type of cordectomy were predictive factors of local recurrence (p = 0.049). Considering the TB group and control cases, the 5-year local recurrence-free survival was 95.6% and 80.9%, respectively (p = 0.14). Conclusions: From this first study, toluidine blue staining seems to be a useful modality to improve the rate of the negative resection margins of early glottic cancer (T1a–T2) treated by TLM.

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Section: Introductionmentioning

confidence: 99%

Early Glottic Cancer Treated by Transoral Laser Surgery Using Toluidine Blue for the Definition of the Surgical Margins: A Pilot Study

et al. 2020

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The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial

Jin

Wang²,

Zhan

et al. 2020

Gastrointestinal Endoscopy

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Circulating cell-free DNA-based methylation pattern in plasma for early diagnosis of esophagus cancer

Wang,

Yang,

et al. 2024

PeerJ

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With the increased awareness of early tumor detection, the importance of detecting and diagnosing esophageal cancer in its early stages has been underscored. Studies have consistently demonstrated the crucial role of methylation levels in circulating cell-free DNA (cfDNA) in identifying and diagnosing early-stage cancer. cfDNA methylation pertains to the methylation state within the genomic scope of cfDNA and is strongly associated with cancer development and progression. Several research teams have delved into the potential application of cfDNA methylation in identifying early-stage esophageal cancer and have achieved promising outcomes. Recent research supports the high sensitivity and specificity of cfDNA methylation in early esophageal cancer diagnosis, providing a more accurate and efficient approach for early detection and improved clinical management. Accordingly, this review aims to present an overview of methylation-based cfDNA research with a focus on the latest developments in the early detection of esophageal cancer. Additionally, this review summarizes advanced analytical technologies for cfDNA methylation that have significantly benefited from recent advancements in separation and detection techniques, such as methylated DNA immunoprecipitation sequencing (MeDIP-seq). Recent findings suggest that biomarkers based on cfDNA methylation may soon find successful applications in the early detection of esophageal cancer. However, large-scale prospective clinical trials are required to identify the potential of these biomarkers.

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Chromoendoscopy Using Toluidine Blue Plus Lugol’s Solution for Early Diagnosis of Esophageal Premalignant Lesions and Superficial Neoplasms in High-Risk Patients

Cited by 3 publications

References 19 publications

Early Glottic Cancer Treated by Transoral Laser Surgery Using Toluidine Blue for the Definition of the Surgical Margins: A Pilot Study

Early Glottic Cancer Treated by Transoral Laser Surgery Using Toluidine Blue for the Definition of the Surgical Margins: A Pilot Study

The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy: a multicenter, randomized, double-blind, parallel trial

Circulating cell-free DNA-based methylation pattern in plasma for early diagnosis of esophagus cancer

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