Association of Interleukin-10 -1082 a/G (Rs1800896) Polymorphism With Susceptibility to Gastric Cancer: Meta-Analysis of 6,101 Cases and 8,557 Controls

Abstract

BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer. METHODS: Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. RESULTS: A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A: OR=1.305, 95% CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA: OR=1.252, 95% CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA: OR=1.264, 95% CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A: OR=1.520, 95% CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA: OR=1.571, 95% CI=1.023-2.414; P= 0.039), heterozygote model (GA vs AA: OR=1.465, 95% CI=1.192-1.801; P≤0.001) and dominant model (GG+GA vs AA: OR=1.448, 95% CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations. CONCLUSION: These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians.

Association of Promoter Region Polymorphisms of Interleukin-10 Gene With Susceptibility to Colorectal Cancer: A Systematic Review and Meta-Analysis

“…Several cytokines that modulate the immunologic response have been implicated in the development of cancer (12) . Interleukin-10 (IL-10) is a multifunctional cytokine involved in both innate and Association of promoter region polymorphisms of interleukin-10 gene with susceptibility to colorectal cancer: a systematic review and meta-analysis adaptive immune response, and a wealth of evidence supports its regulatory role in carcinogenesis and tumor growth (13,14) . In addition, increased circulating IL10 has been shown in patients diagnosed with different malignancies, such as hepatocellular carcinoma, autoimmune cancers, and leukemia.…”

“…In addition, increased circulating IL10 has been shown in patients diagnosed with different malignancies, such as hepatocellular carcinoma, autoimmune cancers, and leukemia. The IL10 gene (Gene ID: 3586) has been mapped to human chromosome 1q31-q32, spans 5.2 kb and contains five exons (14) . Many SNPs in the promoter and coding region of IL-10 gene were shown to be associated with cancer risk, and also, studies have showed that the genetic variants played important roles in the transcription and protein expression (15) .…”

Association of IL-6 −174 G>C Polymorphism with Susceptibility to Colorectal Cancer and Gastric Cancer: a Systematic Review and Meta-Analysis

“…The results manifested that the heterogeneity could be mainly attributed by source of controls for CRC and by ethnicity and source of controls for GC. However, CRC and GC have a complex etiology and pathophysiology generated by the interaction of several genes and environmental factors (7,42). Thus, besides the indeterminate number of characteristics that vary among studies, other confounding factors such as age, gender, lifestyle further contribute to between-study heterogeneity (43,44).…”

“…The exact mechanism of CRC and GC is still not fully understood. However, CRC and GC are multifactorial and multistep diseases caused by complex interactions between environmental triggers and genetic factors (6,7). To date, a wide range of gastrointestinal cancer susceptibility gene variations have been evaluated.…”

Association of NAD(P)H Quinine Oxidoreductase 1 rs1800566 Polymorphism with Bladder and Prostate Cancers – a Systematic Review and Meta-Analysis

“…However, between-study heterogeneity can distort the results of a meta-analysis [39,40]. Several factors, such as diversity in study design, sample size, ethnicity, source of controls, genotyp ing method, and deviation from HWE might contribute to results heterogeneity [41,42]. To identify possible factors that contributed to high heterogeneity, we performed subgroup analysis by ethnicity.…”