Impact of alcohol consumption among patients in hepatitis C virus treatment

Vieira-Castro, Andréa Carvalho Maia; Oliveira, Luiz Carlos Marques de

doi:10.1590/s0004-2803.201700000-33

Cited by 12 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…28,58 Given evidence that these patients can still be treated successfully, these restrictions on sobriety are unjustified and prevent access to effective, curative treatment. [59][60][61][62][63][64] In the past, the requirement for HCV specialist care was a formidable obstacle due to system, provider, and patient-based barriers. Patients would not only need a referral to an HCVtreating provider, but would also have to bear the additional time, effort, insurance co-pays, and transportation costs to obtain access to such care.…”

Section: Barriers In the Quest To Eliminate Hcvmentioning

confidence: 99%

Integrating Management of Hepatitis C Infection into Primary Care: the Key to Hepatitis C Elimination Efforts

et al. 2022

View full text Add to dashboard Cite

Elimination of hepatitis C virus (HCV), a leading cause of liver disease in the USA and globally, has been made possible with the advent of highly efficacious direct acting antivirals (DAAs). DAA regimens offer cure of HCV with 8-12 weeks of a well-tolerated once daily therapy. With increasingly straightforward diagnostic and treatment algorithms, HCV infection can be managed not only by specialists, but also by primary care providers. Engaging primary care providers greatly increases capacity to diagnose and treat chronic HCV and ultimately make HCV elimination a reality. However, barriers remain at each step in the HCV cascade of care from screening to evaluation and treatment. Since primary care is at the forefront of patient contact, it represents the ideal place to concentrate efforts to identify barriers and implement solutions to achieve universal HCV screening and increase curative treatment.

show abstract

Section: Barriers In the Quest To Eliminate Hcvmentioning

confidence: 99%

Integrating Management of Hepatitis C Infection into Primary Care: the Key to Hepatitis C Elimination Efforts

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although the biological sequelae of alcohol use on the liver and HCV treatment ineligibility associated with alcohol are well established (McCartney & Beard, 2010; Sims et al, 2017; Sims, Maynard, & Melton, 2016; Singal & Anand, 2007; Stroffolini et al, 2017; Vieira-Castro & Oliveira, n.d. ; Younossi et al, 2013), available data on the consequences of active alcohol use on quality of life, functioning, and coping in HCV patients are limited.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life, Functioning, and Coping in HCV Patients Continuing Versus Ceasing Alcohol Use

Sims

Pollio

et al. 2019

Health Promotion Practice

View full text Add to dashboard Cite

The purpose of this study was to compare quality of life, functioning, and coping among hepatitis C virus (HCV) patients who continued versus ceased alcohol use in the past year. HCV patients ( n = 291) were recruited from three liver and infectious disease clinics. Student’s t test was used to compare HCV patients who were former and active users of alcohol. The majority of HCV patients were male, African American, and without a high school degree. Compared to former users of alcohol, active users of alcohol self-reported lower ratings on home life, personal leisure, and overall quality of life. In the area of functioning, active users of alcohol self-reported lower ratings on home life, close relationships, sex life, and overall functioning. The two groups did not differ on coping. Most HCV clinicians advise HCV patients to avoid alcohol completely because of its adverse biological effects on the liver. Despite this important advice by their HCV clinicians, most HCV patients continue to use alcohol. HCV clinicians can additionally consider advising these patients that continued alcohol use is associated with lower quality of life and functioning as further evidence to convince these patients to avoid alcohol or to participate in alcohol cessation treatment.

show abstract

“…These findings also imply that the interactions between alcohol and HCV are very complex and need to be further illustrated. Although the introduction of direct-acting antiviral (DAA) therapies for treatment of HCV infection has dramatically improved treatment responses and represents a milestone in the HCV treatment landscape, better understanding of the underlying mechanisms responsible for the alcohol effect on HCV infection/replication would provide new insights into their interaction, as well as information for clinical treatment and management of alcoholic patients with chronic HCV infection, which yet does not have standard guidelines for whether or how long alcohol abuse is abstinent before beginning the HCV treatment, even in the DAA era 12 .…”

Section: Introductionmentioning

confidence: 99%

Alcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells

et al. 2018

View full text Add to dashboard Cite

Both alcohol and hepatitis C virus (HCV) infection could induce cellular autophagy in liver cells, which is considered to be essential for productive HCV replication. However, whether alcohol-induced autophagy is involved in the pathogenesis of HCV infection is still poorly understood. Alcohol treatment could induce autophagy in Huh7 cells (a hepatoma cell line that supports HCV JFH-1 replication), evidenced by the increase of LC3B-II levels, the conversion of LC3B-I to LC3B-II, and the formation of GFP-LC3 puncta as well as the decrease of p62 level in alcohol-treated cells compared with control cells. Alcohol treatment also significantly increased PIASy (a member of the PIAS family) expression, which can act as a SUMO (small ubiquitin-like modifier protein) E3 ligase to regulate a broader range of cellular processes including autophagy. Overexpression or the silencing expression of PIASy in alcohol-treated Huh7 cells could increase or decrease autophagic activation caused by alcohol treatment, respectively, and thus affect HCV replication correspondingly. In the absence of alcohol, overexpression or silencing expression of PIASy increase or decrease the level of cellular autophagy, judged by the changes of LC3B-II and p62 levels in the presence or absence of chloroquine (CQ), a lysosome inhibitor. More importantly, in the presence of 3-methyladenine (3-MA), an inhibitor in the early stage of autophagy, the effects of overexpression or silencing expression of PIASy on HCV replication were largely blocked. Furthermore, PIASy could selectively drive the accumulation of SUMO1-conjugated proteins, along with upregulation of the expression of several important autophagy factors, including ATG7 and ATG5–ATG12. In conclusion, alcohol promotes HCV replication through activation of autophagy in Huh7 cells, which partly attributes to its induction of PIASy expression. PIASy-enhanced accumulation of SUMO1-conjugated proteins may contribute to its inducing effect of autophagy. Our findings provide a novel mechanism for the action of alcohol-promoting HCV replication in the context of cellular autophagy.

show abstract

Impact of alcohol consumption among patients in hepatitis C virus treatment

Cited by 12 publications

References 31 publications

Integrating Management of Hepatitis C Infection into Primary Care: the Key to Hepatitis C Elimination Efforts

Integrating Management of Hepatitis C Infection into Primary Care: the Key to Hepatitis C Elimination Efforts

Quality of Life, Functioning, and Coping in HCV Patients Continuing Versus Ceasing Alcohol Use

Alcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells

Contact Info

Product

Resources

About