Essential trichomegaly: case report

Abstract

The present study reports two cases of symptomatic essential trichomegaly. Tri chomegaly may develop in various diseases, including anorexia nervosa, hypothyroidism, pregnancy, pretibial myxedema, systemic lupus erythematosus, vernal keratoconjunctivitis, and uveitis. The exact incidence trichomegaly is unknown, and the condition remains sporadically reported. Two cases of symptomatic trichomegaly without any associated systemic disorder are presented in this paper. Nazareth et al. (11) documented 23 medications associated with tri chomegaly. The most common were prostaglandin analogs, cyclosporine, interferon, topiramate and cetuximab. Keywords CONClUSIONTrimming and epilation have been found to be satisfactory and safe therapeutic options. The exact incidence of eyelash trichomegaly is unknown, and the condition is rare and sporadically reported.

Fibroblast Growth Factor 5 (FGF5) and Its Missense Mutant FGF5-H174 Underlying Trichomegaly: A Molecular Dynamics Simulation Investigation

“…Recent evidence suggested that Y174 is a highly conserved residue across species possessing critical roles in structure formation and functions of FGF5. The missense mutation of this residue into histidine (Y174H) may the underlying cause of trichomegaly, a disorder characterized by excessively long, pigmented, and thick eyelashes (Higgins et al, 2014; Rossetto et al, 2013). Y174 is characterized by its hydrophobic aromatic function group, whereas H174 is characterized by a positively charged imidazole functional group ( Figure 1A & B, top panels ).…”