Avaliação estrutural do polo posterior em pacientes com doença de Behçet

Corrêa, T. P.; Arantes, Tiago Eugênio Faria e; Lima, Verônica Castro; Muccioli, Cristina

doi:10.1590/s0004-27492011000600002

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Researchers investigating the correlation between the decrease in visual acuity and macular thickness revealed different results (9)(10)(11)22) . Takeuchi et al (9) found that macular thinning occurred as the duration of uveitis prolonged.…”

Section: Discussionmentioning

confidence: 99%

Retinal thickness profiles in patients with Behçet uveitis during remission

Farisogullari¹,

Öztürk²

2022

ABO

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The purpose of this study was to evaluate the intraretinal layer thickness in the macular region and its correlation with the duration of uveitis and visual acuity in patients with Behçet uveitis. Methods: In this cross-sectional study, we included 93 eyes of 57 patients with Behçet uveitis and 100 eyes of 50 healthy individuals admitted to a tertiary center from January to September 2017. We performed macular measurements in all subjects via spectral domain-optical coherence tomography (SD-OCT) and divided the retina into layers using automated segmentation software on the SD-OCT device. We then compared layer thicknesses between the patient and control groups and evaluated the correlation between OCT parameters and the duration of uveitis and visual acuity in the patient group. Results: Our records show a mean age of 37.9 ± 10.8 (18-64) years and 37.7 ± 12.2 (21-61) years in the patient and control groups (p=0.821), respectively. Meanwhile, data reveal a mean duration of uveitis of 6.9 ± 4.7 (1-20) years. We found a reduction in the total outer layer thickness in the patient group (p<0.001). However, we did not find a statistically significant difference in the inner retinal layers except in the inner nuclear layer. The duration of uveitis negatively correlated with the outer retinal layer's thickness (correlation coefficient = -0.250). On the other hand, visual acuity positively correlated with the central macular, the total inner layer, and the outer retinal layer thicknesses (correlation coefficients: 0.194, 0.154, and 0.364, respectively). However, the inner nuclear layer negatively correlated with visual acuity. Conclusions: Using retinal segmentation via SD-OCT for follow-ups can help estimate visual loss in patients with Behçet uveitis, which can cause significant changes in intraretinal layers in the macular region.

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Section: Discussionmentioning

confidence: 99%

Retinal thickness profiles in patients with Behçet uveitis during remission

Farisogullari¹,

Öztürk²

2022

ABO

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“…It is noteworthy that the literature encloses some controversial studies regarding the correlation between macular thickness and visual acuity. Several studies reported moderate to strong correlations between macular thickness and visual acuity, however, some reported weak or no correlation 9 , 10 , 11 , 12 , given the fact that the alterations or disruption of particular retinal sublayers, including ORL, may be associated with visual acuity.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography – A Predictor of Visual Acuity in Schizophrenia

Bozali

Yalınbaş

2022

Klin Monbl Augenheilkd

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Background The aim of this study was to evaluate the thickness of the outer retinal layer (ORL) together with macular thickness and changes in the retinal nerve fiber layer (RNFL) in patients with schizophrenia in comparison with healthy controls. Methods This study included 114 eyes of 57 patients diagnosed with schizophrenia and 114 eyes of 57 healthy controls. Central foveal thickness (CFT), central macular thickness (CMT), and ORL thickness were measured in both groups via the images obtained by spectral-domain optical coherence tomography (SD-OCT). RNFL was also assessed in four quadrants (inferior, superior, temporal, nasal). CMT measurements were presented as the average thickness of the macula in the central 1 mm area on the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. The ORL thickness was defined as the distance between the external limiting membrane and retinal pigment epithelium at the center of the foveal pit. Results The mean age of 57 patients was 37 ± 10 years, of whom 34 (60%) were male and 23 (40%) female. No statistically significant difference was found between groups in terms of age and gender (p = 0.8 for age, p = 0.9 for gender). There was no statistically significant difference in the mean CMT between the two groups (p = 0.1). The mean ORL thickness in the two groups was 99.8 ± 8.3 and 103.7 ± 6.2, respectively, and was significantly decreased in the schizophrenia group (p = 0.005). RNFL analysis demonstrated significant thinning in the inferior and superior quadrants compared to healthy controls (p < 0.001 and p = 0.017, respectively). Conclusions SD-OCT findings – especially ORL and RNFL thickness – may be related to the neurodegenerational changes in schizophrenia.

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