Aplicações oftalmológicas do ácido hialurônico

Figueirêdo, Eugênio Santana de; Macedo, André Casimiro de; Figueirêdo, Priscila Fechine Ribeiro de; Figueirêdo, Régis Santana de

doi:10.1590/s0004-27492010000100018

Cited by 7 publications

(5 citation statements)

References 12 publications

(16 reference statements)

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“…The main characteristics of HA that makes it a very attractive molecule are: (1) high hygroscopicity; (2) viscoelastic nature; (3) high biocompatibility; (4) non-immunogenicity and (5) it does not generate toxic products when degraded. The use of HA has seen results in ophthalmic cosmetics [ 15 ], in surgery [ 16 ], as a drug delivery system [ 17 ], in rheumatology [ 18 ], in otolaryngology [ 19 ] and in urology [ 20 ]. The many applications of hyaluronic acid are illustrated in Fig.…”

Section: Introductionmentioning

confidence: 99%

Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms

Oliveira

Carvalho²,

Gomes

et al. 2016

Microb Cell Fact

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Hyaluronic acid, or HA, is a rigid and linear biopolymer belonging to the class of the glycosaminoglycans, and composed of repeating units of the monosaccharides glucuronic acid and N-acetylglucosamine. HA has multiple important functions in the human body, due to its properties such as bio-compatibility, lubricity and hydrophilicity, it is widely applied in the biomedical, food, health and cosmetic fields. The growing interest in this molecule has motivated the discovery of new ways of obtaining it. Traditionally, HA has been extracted from rooster comb-like animal tissues. However, due to legislation laws HA is now being produced by bacterial fermentation using Streptococcus zooepidemicus, a natural producer of HA, despite it being a pathogenic microorganism. With the expansion of new genetic engineering technologies, the use of organisms that are non-natural producers of HA has also made it possible to obtain such a polymer. Most of the published reviews have focused on HA formulation and its effects on different body tissues, whereas very few of them describe the microbial basis of HA production. Therefore, for the first time this review has compiled the molecular and genetic bases for natural HA production in microorganisms together with the main strategies employed for heterologous production of HA.

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Section: Introductionmentioning

confidence: 99%

Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms

Oliveira

Carvalho²,

Gomes

et al. 2016

Microb Cell Fact

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“…Ophthalmic viscoelastics: Hyaluronic acid is widely use in ophthalmology due to its viscosupplementant properties and its presence in the cornea, the sclera and the vitreous humor [165]. Ophthalmic viscoelastics are HA-based products used to maintain the structure of the eye's capsule, mainly in the phacoemulsification (removal of the eye's vitreous humor) step of cataract surgery [166], but also in other surgical procedures such as vitreoretinal surgery, anterior segment surgery, glaucoma surgery, and corneal transplantation [167].…”

Section: Global Markets and Manufacturersmentioning

confidence: 99%

Hyaluronan: From Biomimetic to Industrial Business Strategy

Murano

Perin

Khan

et al. 2011

Natural Product Communications

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Hyaluronan (hyaluronic acid) is a naturally occurring polysaccharide of a linear repeating disaccharide unit consisting of β-(1→4)-linked D-glucopyranuronic acid and β-(1→3)-linked 2-acetamido-2-deoxy-D-glucopyranose, which is present in extracellular matrices, the synovial fluid of joints, and scaffolding that comprises cartilage. In its mechanism of synthesis, its size, and its physico-chemical properties, hyaluronan is unique amongst other glycosaminoglycans. The network-forming, viscoelastic and its charge characteristics are important to many biochemical properties of living tissues. It is an important pericellular and cell surface constituent; its interaction with other macromolecules such as proteins, participates in regulating cell behavior during numerous morphogenic, restorative, and pathological processes in the body. The knowledge of HA in diseases such as various forms of cancers, arthritis and osteoporosis has led to new impetus in research and development in the preparation of biomaterials for surgical implants and drug conjugates for targeted delivery. A concise and focused review on hyaluronan is timely. This review will cover the following important aspects of hyaluronan: (i) biological functions and synthesis in nature; (ii) current industrial production and potential biosynthetic processes of hyaluronan; (iii) chemical modifications of hyaluronan leading to products of commercial significance; and (iv) and the global market position and manufacturers of hyaluronan.

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“…Formerly, ointment bases were used as viscous vehicles for this purpose; however, their use is now limited due to the undesirable side-effect of blurred vision. The use of viscosity-inducing agents—cellulose derivatives [ 5 ] and hyaluronic acid [ 6 ]—to reduce the formulation drainage could replace the use of an ointment base. Additionally, the use of bioadhesive polymers, such as chitosan and its derivatives [ 7 , 8 , 9 ], sodium alginate, xanthan and carrageenan [ 10 ], may help to prolong the corneal contact time.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Corneal Penetration of a Poorly Permeable Drug Using Bioadhesive Multiple Microemulsion Technology

et al. 2020

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Corneal penetration is a key rate limiting step in the bioavailability of topical ophthalmic formulations that incorporate poorly permeable drugs. Recent advances have greatly aided the ocular delivery of such drugs using colloidal drug delivery systems. Ribavirin, a poorly permeable BCS class-III drug, was incorporated in bioadhesive multiple W/O/W microemulsion (ME) to improve its corneal permeability. The drug-loaded ME was evaluated regarding its physical stability, droplet size, PDI, zeta potential, ultrastructure, viscosity, bioadhesion, in vitro release, transcorneal permeability, cytotoxicity, safety and ocular tolerance. Our ME possessed excellent physical stability, as it successfully passed several cycles of centrifugation and freeze–thaw tests. The formulation has a transparent appearance due to its tiny droplet size (10 nm). TEM confirmed ME droplet size and revealed its multilayered structure. In spite of the high aqueous solubility and the low permeability of ribavirin, this unique formulation was capable of sustaining its release for up to 24 h and improving its corneal permeability by 3-fold. The in vitro safety of our ME was proved by its high percentage cell viability, while its in vivo safety was confirmed by the absence of any sign of toxicity or irritation after either a single dose or 14 days of daily dosing. Our ME could serve as a vehicle for enhanced ocular delivery of drugs with different physicochemical properties, including those with low permeability.

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Aplicações oftalmológicas do ácido hialurônico

Cited by 7 publications

References 12 publications

Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms

Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms

Hyaluronan: From Biomimetic to Industrial Business Strategy

Enhanced Corneal Penetration of a Poorly Permeable Drug Using Bioadhesive Multiple Microemulsion Technology

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