Acometimento ocular em pacientes com mansonelose

Abstract

Association between Mansonella ozzardi infection and corneal lesions with no evident etiology was observed in this study, but the lack of conclusive findings on histopathology and PCR make us doubt the corneal involvement in mansonelliasis. Large studies of high mansonelliasis prevalence populations and extensive employment of microfilaria identification tests in ocular tissue are needed to evaluate the microfilaria corneal pathogenicity.

Mansonella ozzardi (Nematoda: Onchocercidae) in the riverine population of the Tefé River, State of Amazonia, Brazil

“…This study revealed a wide distribution of this filarial parasite in the middle Solimões region and in the high tributaries of the Solimões basin. The M. ozzardi prevalence rates were lower (6.3%) than those previously recorded in Solimões River communities, including rates of 23.9% in Codajás, 10.0 to 17.8% in Coari, 2.5 to 18.7% in Tefé, and 18.4 to 18.9% in Coari 1,3,4 . In addition, the communities located beside the middle and upper segments of the river presented a higher frequency of M. ozzardi infections, which was possibly related to the greater abundance of black fly vectors.…”

Mansonella ozzardi in Brazil: prevalence of infection in riverine communities in the Purus region, in the state of Amazonas

“…In occupations where individuals spent a lot of time in field conditions, the prevalence of infection was greater than in individuals in urban/domiciliary conditions. The prevalence in the Pauini population was higher than had been previously reported for the following municipalities of AM: Fonte Boa (17.8%), São Paulo de Olivença (12.6%), Uapés (10.5%), Coari (10%) and Codajas (23.9%) (Lacerda & Rachou 1956), Lábrea (4.4% and 5.9%) (Shelley 1975, Tavares 1981 and Coari (18.9%) (Cohen et al 2008). However, the prevalence was lower than that reported in the high Solimões (45.7%) and Pauini (28.4%) indigenous communities (Moraes et al 1978, Medeiros et al 2007).…”

“…Several infected individuals show no symptoms; however, clinical manifestations that decrease the quality of life such as moderate fever, coldness in the legs, joint pains and headaches have been attributed to M. ozzardi infection (Batista et al 1960b). Recently, the presence of ocular lesions has been reported as possibly associated with M. ozzardi infection (Branco et al 1998, Cohen et al 2008.The microfilaria M. ozzardi was detected in Brazil in the 1940s and 1950s (Deane 1949, Deane et al 1954, Lacerda & Rachou 1956) and was described as a potentially extensive problem (Moraes 1958). Recently, some studies have shown that this filaria is still found with high prevalence (Medeiros et al 2007(Medeiros et al , 2008 and that simuliids are incriminated in the parasite's transmission in Brazil (Cerqueira 1959, Shelley & Shelley 1976, Shelley et al 1980).…”

“…Several infected individuals show no symptoms; however, clinical manifestations that decrease the quality of life such as moderate fever, coldness in the legs, joint pains and headaches have been attributed to M. ozzardi infection (Batista et al 1960b). Recently, the presence of ocular lesions has been reported as possibly associated with M. ozzardi infection (Branco et al 1998, Cohen et al 2008.…”

Pulmonary localization of Mansonella perstans in a 16 months-old male patient in a tertiary care hospital in Bukavu, Democratic Republic of Congo

“…At least part of the pathogenesis of this disease may be induced by the immune response to the presence of the parasite, and eosinophilia is generally present as well. 2,3 In this case, the patient had a misleading malnutrition with edema of the legs, pruritic cutaneous lesions, pneumonia and plural effusion. Peripheral blood stain showed M. perstans microfilaria.…”