Pulmonary localization of Mansonella perstans in a 16 months-old male patient in a tertiary care hospital in Bukavu, Democratic Republic of Congo

Kabego, Landry; Kasengi, Joe Bwija; Mirindi, Patrick; Ruhanya, Vurayai; Lupande, David; Bulabula, Andre N H; Ngoma, Patrick

doi:10.11599/germs.2016.1101

Cited by 4 publications

(3 citation statements)

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“…The degenerating larvae release antigenic constituents which trigger an immune response that is characteristic of a Type 2 reaction and induce asthma-like symptoms. In addition, the human filaria Mansonella perstans has been reported to induce pleural effusion in some clinical cases [ 6 – 9 ]. Finally zoonotic Dirofilaria immitis filarial infections often result in pulmonary inflammation and damage due to the migration of larvae and/or adult parasites to the lungs [ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents

et al. 2020

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Background Pulmonary manifestations are regularly reported in both human and animal filariasis. In human filariasis, the main known lung manifestations are the tropical pulmonary eosinophilia syndrome. Its duration and severity are correlated with the presence of microfilariae. Litomosoides sigmodontis is a filarial parasite residing in the pleural cavity of rodents. This model is widely used to understand the immune mechanisms that are established during infection and for the screening of therapeutic molecules. Some pulmonary manifestations during the patent phase of infection with L. sigmodontis have been described in different rodent hosts more or less permissive to infection. Methods Here, the permissive Mongolian gerbil (Meriones unguiculatus) was infected with L. sigmodontis. Prevalence and density of microfilariae and adult parasites were evaluated. Lungs were analyzed for pathological signatures using immunohistochemistry and 3D imaging techniques (two-photon and light sheet microscopy). Results Microfilaremia in gerbils was correlated with parasite load, as amicrofilaremic individuals had fewer parasites in their pleural cavities. Fibrotic polypoid structures were observed on both pleurae of infected gerbils. Polyps were of variable size and developed from the visceral mesothelium over the entire pleura. The larger polyps were vascularized and strongly infiltrated by immune cells such as eosinophils, macrophages or lymphocytes. The formation of these structures was induced by the presence of adult filariae since small and rare polyps were observed before patency, but they were exacerbated by the presence of gravid females and microfilariae. Conclusions Altogether, these data emphasize the role of host-specific factors in the pathogenesis of filarial infections.

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Section: Introductionmentioning

confidence: 99%

Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents

et al. 2020

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“…Cough, dyspnoea, wheeze Fever, malaise, weight loss [86] Bilateral reticulonodular shadowing, mediastinal lymphadenopathy [86] Mansonella ozzardi [87] Cough, pneumonia and plural effusion Base reticular opacity Dirofilaria immitis [75,88] Chest pain, cough, haemoptysis, wheezing, fever, chills and malaise Coin lesion -established lesions a central necrotic area is surrounded by a granulomatous reaction and fibrous wall. Dead worms may calcify.…”

Section: Filariasis-wuchereria Bancroftimentioning

confidence: 99%

Pleuropulmonary parasitic infections of present times-A brief review

Princess¹,

Vadala²

2018

Journal of Microbiology and Infectious Diseases

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Pleuropulmonary infections are not uncommon in tropical and subtropical countries. Its distribution and prevalence in developed nations has been curtailed by various successfully implemented preventive health measures and geographic conditions. In few low and middle income nations, pulmonary parasitic infections still remain a problem, although not rampant. With increase in immunocompromised patients in these regions, there has been an upsurge in parasites isolated and reported in the recent past.

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“…Human infections with zoonotic filariasis are reported worldwide [ 8 ] and were first described in modern research over a century ago [ 9 ]. A number of different genera of filaria have been isolated from humans, including Dirofilaria [ 10 , 11 ], Brugia [ 12 , 13 ], Onchocerca [ 14 , 15 ], Dipetalonema [ 16 , 17 ], Loa [ 18 , 19 ], and Mansonella [ 20 , 21 ]. The location of these parasites within the human body varies from species to species.…”

Section: Introductionmentioning

confidence: 99%

Beyond Tradition: Exploring Cutting-Edge Approaches for Accurate Diagnosis of Human Filariasis

Pietrzak,

Łuczak,

Wiśniewski

2024

Pathogens

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Filariasis is recognised as a global public health threat, particularly in tropical and subtropical regions. It is caused by infection with a nematode parasite of the superfamily Filarioidea, including Wuchereria bancrofti, Brugia malayi, Onchocerca volvulus, and Onchocerca lupi. Three main types of filariasis have been classified: lymphatic filariasis, subcutaneous filariasis, and serous cavity filariasis. The symptoms exhibited by individuals afflicted with filariasis are diverse and contingent upon several variables, including the species of parasite, the host’s health and immune response, and the stage of infection. While many classical parasitological techniques are considered indispensable tools for the diagnosis of parasitic infections in humans, alternative methods are being sought due to their limitations. Novel tests based on host–parasite interactions offer a rapid, simple, sensitive, and specific diagnostic tool in comparison to traditional parasitological methods. This article presents methods developed in the 21st century for the diagnosis of filariasis caused by invasion from W. bancrofti, B. malayi, O. volvulus, and O. lupi, as well as techniques that are currently in use. The development of modern diagnostic methods based on molecular biology constitutes a significant advancement in the fight against filariasis.

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Pulmonary localization of Mansonella perstans in a 16 months-old male patient in a tertiary care hospital in Bukavu, Democratic Republic of Congo

Abstract: Introduction Mansonella perstans is a human filarial parasite transmitted by biting midges (Diptera: Ceratopogonidae) belonging to the genus Culicoides and it is widely spread in sub-Saharan Africa. While

Cited by 4 publications

References 9 publications

Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents

Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents

Pleuropulmonary parasitic infections of present times-A brief review

Beyond Tradition: Exploring Cutting-Edge Approaches for Accurate Diagnosis of Human Filariasis

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