Colchicine in the treatment of the inflammatory phase of Graves' ophthalmopathy: a prospective and randomized trial with prednisone

Abstract

Colchicine had a beneficial effect on the inflammatory phase of GO without the side effects of prednisone.

Ultrasonography compared to magnetic resonance imaging in thyroid-associated Graves' ophthalmopathy

“…CAS helps predict response to treatment (4,8,16,27) but works better if combined with US reflectivity (8)(9)(10)16,26,31). On the other hand, the orbital octreoctide scan method (10,30) and MRI are more expensive and not as readily available in healthcare facilities; furthermore, as stated by Hoh and cols.…”

“…Furthermore, the T2 signal intensity of the muscles was compared to the SA signal and expressed as a signal-intensity ratio (SIR) in order to reduce individual differences and to compensate for the slight variation in machine sensitivity when used on subsequent occasions. This ratio also eliminates the need to submit the control group to MRI (10,21,24,(27)(28)(29). An increase in SIR might indicate activity due to edema presence (11,18,27,28,30).…”

Current Approach to Graves' Ophthalmopathy: Review

“…51 In a comparative study with prednisone and colchicine, it was shown that it could be useful in the treatment of active phase of GO. 52 S So om ma at to os st ta at ti in n a an na al lo og gu ue es s have been used in the treatment of GO, however, not any good results were obtained. 53 S Se el le en ni iu um m: : Selenium can provide positive effects in mild to moderate GO cases by reducing the production of proinflammatory cytokines.…”

Treatment of Graves' ophthalmopathy

“…Stamal и соавт. [46] в 2006 г. опубликовали результаты исследования, сравнивающего эффек тивность колхицина (1,5 мг/сут) и преднизолона (0,75 мг/кг/сут) у 22 пациентов с умеренно выражен ной формой ИО. На фоне лечения в обеих группах пациентов наблюдалось по данным МРТ снижение активности офтальмопатии и уменьшение отека.…”