Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats

Cariello, Angelino Júlio; Casanova, Fábio Henrique Cacho; Filho, Acácio Alves de Souza Lima; Juliano, Yára; Tabosa, Angela

doi:10.1590/s0004-27492006000300003

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…42 The opacification of the crystalline occurs by aggregation of cytoplasmic lens proteins. 43 In 2006, Cariello et al 44 revealed that EA prevents cataract formation in Wistar rats but attributed nothing to the HSP role for the underlying mechanisms of the EA effects on preventing cataract formation. 44 …”

Section: Education and Practicementioning

confidence: 99%

A Review of the Potential Effect of Electroacupuncture and Moxibustion on Cell Repair and Survival: The Role of Heat Shock Proteins

Cakmak¹

2009

Acupunct Med

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In recent years, a considerable amount of research has been focused on the underlying mechanisms of electroacupuncture and moxibustion assisted tissue repair. Intracellular protein denaturation is a significant pathological step of acute conditions such as stroke, myocardial infarction and acute pancreatitis. Protein aggregation can be observed after the protein denaturation step in chronic diseases of the central nervous system like Alzheimer's and Parkinson's disease, and also in other chronic system diseases including cataract formation. Heat shock proteins (HSPs) are fundamental for intracellular protein repair and work by preventing protein aggregation and assisting denaturated proteins to refold. Further, HSPs can also function for extracellular cell signalling. The focus of this review is to analyse the data studying electroacupuncture and moxibustion induced HSPs, and how acupuncture can survive cells from apoptosis under stress.

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Section: Education and Practicementioning

confidence: 99%

A Review of the Potential Effect of Electroacupuncture and Moxibustion on Cell Repair and Survival: The Role of Heat Shock Proteins

Cakmak¹

2009

Acupunct Med

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“…Acupuncture is a TCM technique used to treat several diseases (BENSKY, 1981). In Western medicine, it is widely used as adjunctive therapy to allopathic treatments (CARIELLO et al, 2006;CHO & KIM, 2008;CHU & POTTER, 2002;KIM, Y. et al 2005). The therapeutic effects of acupuncture are observed throughout the body, and several studies have shown its advantageous effects on several conditions in the visual system (ERNST, 2006), including KCS (ELIASON et al, 2007) and glaucoma (KURUSU et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effect of acupuncture on intraocular pressure and tear production in healthy horses

et al. 2022

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Acupuncture is an ancient Chinese form of therapy that involves needle stimulation of specific points on the body for therapeutic and homeostatic effects. In ophthalmology, acupuncture helps as a conventional or adjuvant therapy for numerous eye disorders, including myopia, strabismus, dry eye, and cataracts. This study aimed to evaluate the effect of acupuncture on tear production (TP) and intraocular pressure (IOP) in horses. Ten healthy horses, females and males with ages varying between eight months and nine years, were used. Schirmer’s I test and applanation tonometry were used to evaluate the basal TP and IOP of both eyes. The measurements were taken immediately before (T10) the insertion of the needles and 5 (T5), 15 (T15), 30 (T30) and 60 (T60) minutes and 24 (T24) hours after a 20-minute acupuncture session. Mean values of both eyes were analyzed over time. TP increased in 50% of the animals at T5, T15 and T24, in 30% at T30, and in 40% at T60, with an increase of up to 8.5 mm/min at T15 and T60. In addition, there was a significant difference between T24 and T30, with a 14.1% increase in TP at T24. Meanwhile, IOP decreased in 50% of the animals at T5 and T30, in 20% at T15, in 60% at T60, and in 70% at T24. Thus, we suggest that acupuncture is a technique that can benefit horses with diseases that alter these parameters, either alone or as an adjunct in conventional therapeutic protocols.

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“…It is estimated that a delay of 10 years in the development of the cataract would reduce the necessity for surgery in 45 %, saving millions (Cariello et al 2006). Therefore, there is a search for pharmacological intervention that will maintain the transparency of the lens.…”

Section: Introductionmentioning

confidence: 99%

Grape seed extract and Zinc containing nutritional food supplement delays onset and progression of Streptozocin-induced diabetic cataract in Wistar rats

et al. 2014

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Prevention of hyperglycemia and enhancement of antioxidant defense mechanisms remain major goals in the treatment of diabetic cataract. Earlier, we reported strong antihyperglycemic and in vitro antioxidant potential of the combined formulation of grape seed extract and Zincovit tablets. Therefore, the current study was designed to investigate effects of combined formulation of grape seed extract and Zincovit tablets against streptozocin-induced diabetic cataract in Wistar rats. Adult Wistar rats were selected and diabetes was induced by streptozocin (35 mg/kg, i.p) and divided into four groups (group II-V). The normal control (group I) and streptozocin-induced diabetic cataract control rats received only vehicle. Groups III, IV and V animals received orally 40, 80 and 160 mg/kg of combined formulation of Zincovit tablets with grape seed extract respectively for a period of 150 days. The biochemical pathways involved in the pathogenesis of cataract such as oxidative stress, polyol pathway and alterations in adenosine triphosphate, glucose-6-phosphate dehydrogenase and blood glucose were investigated, to understand the possible mechanism of action of combined formulation of grape seed extract and Zincovit tablets. Rats treated with combined formulation of grape seed extract and Zincovit tablets delayed the progression of diabetic cataract as well as it showed significant alterations in oxidative stress markers along with blood glucose, aldose reductase, glucose-6-phosphate dehydrogenase and adenosine triphosphate level in lens. Over all, the results suggest that single combined formulation of grape seed extract and Zincovit tablets may be of great value in delaying diabetic cataract of human subjects as nutritional food supplement.

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Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats

Cited by 6 publications

References 27 publications

A Review of the Potential Effect of Electroacupuncture and Moxibustion on Cell Repair and Survival: The Role of Heat Shock Proteins

A Review of the Potential Effect of Electroacupuncture and Moxibustion on Cell Repair and Survival: The Role of Heat Shock Proteins

Effect of acupuncture on intraocular pressure and tear production in healthy horses

Grape seed extract and Zinc containing nutritional food supplement delays onset and progression of Streptozocin-induced diabetic cataract in Wistar rats

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