Endoftalmite por Candida albicans

Serracarbassa, Pedro Durães; Dotto, Patrícia de Freitas

doi:10.1590/s0004-27492003000500027

Cited by 3 publications

(2 citation statements)

References 75 publications

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“…Although a literature review showed that endophthalmitis presents in patients with general health vulnerabilities (29) , Godoy et al (30) show a case of endophthalmitis following penetrating keratoplasty. Knowing the penetrating capacity of the organisms and the changes in Descemet's membrane facilitating intraocular invasion, and having no feedback on cases undergoing transplantation, we conclude that there may have been cases of fungal endophthalmitis in our sample without our knowledge.…”

Section: Discussionmentioning

confidence: 99%

“…If this is not done, a sample can be collected from the ulcer, due to the significant probability of discovering the diagnosis even after the onset of treatment. As test results take a long time, and taking into account the urgency of the situation, in vivo confocal microscopy can be used to guide treatment earlier (25)(26)(27)(28)(29)(30)(31)(32)(33) .…”

Section: Discussionmentioning

confidence: 99%

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Reflexões sobre a ceratite fúngica por meio dos achados de exames histopatológicos

Monte

Stadtherr

2013

Rev. bras.oftalmol.

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Purpose: The study of fungal invasion and pathogenicity in corneal tissue observed through the histopathological examination of specimens obtained through penetrating keratoplasty ('PKP') of samples obtained from an Eye Bank ('EB'), with the aim of applying findings in diagnosis and treatment of the condition (n=35), a faixa etária acima de 60 anos a mais numerosa com 1/3 dos pacientes. Os casos de ceratite fúngica correspondiam à média de 6,4% (n=597) do material recebido no BOO e 1,65% (n=2310) dos transplantes ocorrido com o material fornecido nos últimos 5 anos. Pelas informações dos cirurgiões 39,5% (n=38) dos casos deviam-se a perfuração corneana. Usando as datas dos transplantes foi feita uma Tábua de Observação. Em 11 (n=38) casos, a córnea procedia de transplante anterior. As formas leveduriformes nos tecidos corneanos eram de 63% (n=38). Em 50% (n=38) dos casos o infiltrado inflamatório era pequeno ou inexistente. A camada de Descemet estava íntegra em 13% (n=38), enquanto eram encontrados fungos na superfície corneana de 45% (n=38) dos casos. Conclusão: A coleta do material poderá ser feita com sucesso mesmo depois de instalado o tratamento, entretanto, nas úlceras de córnea deve ser feito preferentemente a coleta de material com espátula para exame laboratorial e a microscopia confocal in vivo. A predominância das leveduras poderá ser devido a alterações morfológicas do fungo sofridas no tecido corneano. A penetração intraocular é facilitada por alterações da Camada de Descemet e pela própria capacidade do fungo de penetrar nos tecidos justificando o tratamento sistêmico desde o início. Descritores: Ceratite/diagnóstico; Ceratite/patologia; Infecções oculares fúngicas/diagnósticoThe authors declare no conflicts of interest

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Reflexões sobre a ceratite fúngica por meio dos achados de exames histopatológicos

Monte

Stadtherr

2013

Rev. bras.oftalmol.

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Susceptibility of Candida albicans Strains Isolated from Vaginal Secretion in Front of the Mycocins of Wickerhamomyces anomalus

Rosseto

Martelli

Silva

et al. 2022

Probiotics & Antimicro. Prot.

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Molecular modeling of inhibitors against fructose bisphosphate aldolase from Candida albicans

Amorim

Lima

Rosário

et al. 2018

In Silico Pharmacol.

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Candida albicans is an opportunistic pathogen that causes from vulvovaginal and oropharyngeal candidiasis to systemic infections. The enzyme 1,6-fructose bisphosphate aldolase class II (FBA II), is a macromolecule existing only in lower organisms, being essential for the survival of the pathogen due to its function of maintaining the glycolysis process. The aim of this paper was to evaluate the inhibitors of FBA II regarding their physicochemical, pharmacokinetic and toxicological properties and apply concepts of rational drug development to propose new compounds for the treatment of fungal infections of C. albicans. Physicochemical (HyperChem software and the webserver cactus) and ADME/Tox (PreADMET webserver) properties were calculated to four inhibitors described in the literature and three analogues. None of the compounds presented in this study violated RO5, however all inhibitors demonstrated low or moderate human intestinal absorption (HIA), as well as low or moderate permeability in Caco-2 and MDCK, poor plasma proteins binding (PPB) and low permeability of the blood-brain barrier (BBB); however, Compound 4 is the exception for BBB permeability, being also the only nonmutagenic compound, and therefore, used as a lead compound. Analogues B and C presented high HIA, weak PPB and low BBB permeability, as well as a positive prediction for carcinogenicity in rats and mouse and non-mutagenicity in the Ames test. Through the evaluations carried out, it was concluded that the analogues B and C have proved to be promising candidates for oral administration drugs in the treatment of fungal infections of the genus Candida.

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Endoftalmite por Candida albicans

Cited by 3 publications

References 75 publications

Reflexões sobre a ceratite fúngica por meio dos achados de exames histopatológicos

Reflexões sobre a ceratite fúngica por meio dos achados de exames histopatológicos

Susceptibility of Candida albicans Strains Isolated from Vaginal Secretion in Front of the Mycocins of Wickerhamomyces anomalus

Molecular modeling of inhibitors against fructose bisphosphate aldolase from Candida albicans

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