Prevalence of vitamin D deficiency is higher in patients with Paget's disease of bone compared with age-matched controls

Griz, Luiz; Bandeira, Francisco; Diniz, Erik Trovão; Cabral, Marcelo; Freese, Eduardo

doi:10.1590/s0004-27302013000700002

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Several studies, including recent surveys in large patient cohorts, demonstrated that vitamin D deficiency (25OHD levels < 20 ng/ml) is frequent in PDB [ 126 , 131 , 132 ]. As previously outlined, N-BP treatment (particularly in case of potent intravenous compounds) may result in hypocalcemia that is more common in case of vitamin D deficiency.…”

Section: Results and Recommendationsmentioning

confidence: 99%

Diagnosis and treatment of Paget’s disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS)

Rendina,

Falchetti,

Diacinti

et al. 2024

J Endocrinol Invest

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Introduction Paget’s disease of bone is a focal skeletal disorder causing bone deformities and impairing bone quality. Despite the prevalence of asymptomatic cases is increasing, the progression of the disease can lead to invalidating complications that compromise the quality of life. Doubts on clinical and therapeutic management aspects exist, although beneficial effects of antiresorptive drugs, particularly bisphosphonates are known. However, limited information is available from randomized controlled trials on the prevention of disease complications so that somewhat contrasting positions about treatment indications between expert panels from the main scientific societies of metabolic bone diseases exist. This task force, composed by expert representatives appointed by the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases and members of the Italian Association of Paget’s disease of bone, felt the necessity for more specific and up to date indications for an early diagnosis and clinical management. Methods Through selected key questions, we propose evidence-based recommendations for the diagnosis and treatment of the disease. In the lack of good evidence to support clear recommendations, available information from the literature together with expert opinion of the panel was used to provide suggestions for the clinical practice. Results and conclusion Description of the evidence quality and support of the strength of the statements was provided on each of the selected key questions. The diagnosis of PDB should be mainly based on symptoms and the typical biochemical and radiological features. While treatment is mandatory to all the symptomatic cases at diagnosis, less evidence is available on treatment indications in asymptomatic as well as in previously treated patients in the presence of biochemical recurrence. However, given the safety and long-term efficacy of potent intravenous bisphosphonates such as zoledronate, a suggestion to treat most if not all cases at the time of diagnosis was released.

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Section: Results and Recommendationsmentioning

confidence: 99%

Diagnosis and treatment of Paget’s disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS)

Rendina,

Falchetti,

Diacinti

et al. 2024

J Endocrinol Invest

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“…For patients with different diseases and receiving long-term medication, studies ( 63 – 65 ) showed that several drugs (e.g. antiepileptic agents, glucocorticoids, antiretroviral or anti-oestrogen drugs) interfered with vitamin D metabolism, which resulted in patients being more likely to have low vitamin D status.…”

Section: Human Intervention Studies On the Relative Effects Of Calcifmentioning

confidence: 99%

25(OH)D₃-enriched or fortified foods are more efficient at tackling inadequate vitamin D status than vitamin D₃

2017

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The ability to synthesise sufficient vitamin D through sunlight in human subjects can be limited. Thus, diet has become an important contributor to vitamin D intake and status; however, there are only a few foods (e.g. egg yolk, oily fish) naturally rich in vitamin D. Therefore, vitamin D-enriched foods via supplementing the animals’ diet with vitamin D or vitamin D fortification of foods have been proposed as strategies to increase vitamin D intake. Evidence that cholecalciferol (vitamin D3) and calcifediol (25(OH)D3) content of eggs, fish and milk increased in response to vitamin D3 supplementation of hens, fish or cows’ diets was identified when vitamin D-enrichment studies were reviewed. However, evidence from supplementation studies with hens showed only dietary 25(OH)D3, not vitamin D3 supplementation, resulted in a pronounced increase of 25(OH)D3 in the eggs. Furthermore, evidence from randomised controlled trials indicated that a 25(OH)D3 oral supplement could be absorbed faster and more efficiently raise serum 25(OH)D concentration compared with vitamin D3 supplementation. Moreover, evidence showed the relative effectiveness of increasing vitamin D status using 25(OH)D3 varied between 3·13 and 7·14 times that of vitamin D3, probably due to the different characteristics of the investigated subjects or study design. Therefore, vitamin D-enrichment or fortified foods using 25(OH)D3 would appear to have advantages over vitamin D3. Further well-controlled studies are needed to assess the effects of 25(OH)D3 enriched or fortified foods in the general population and clinical patients.

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Vitamin D Status in Paget Disease of Bone and Efficacy–Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D

Rendina

Filippo²,

Merlotti

et al. 2019

Calcif Tissue Int

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Prevalence of vitamin D deficiency is higher in patients with Paget's disease of bone compared with age-matched controls

Cited by 5 publications

References 8 publications

Diagnosis and treatment of Paget’s disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS)

Diagnosis and treatment of Paget’s disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS)

25(OH)D₃-enriched or fortified foods are more efficient at tackling inadequate vitamin D status than vitamin D₃

Vitamin D Status in Paget Disease of Bone and Efficacy–Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D

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Prevalence of vitamin D deficiency is higher in patients with Paget's disease of bone compared with age-matched controls

Cited by 5 publications

References 8 publications

Diagnosis and treatment of Paget’s disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS)

Diagnosis and treatment of Paget’s disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS)

25(OH)D3-enriched or fortified foods are more efficient at tackling inadequate vitamin D status than vitamin D3

Vitamin D Status in Paget Disease of Bone and Efficacy–Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D

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Product

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25(OH)D₃-enriched or fortified foods are more efficient at tackling inadequate vitamin D status than vitamin D₃