Vitamin D Status in Paget Disease of Bone and Efficacy–Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D

Rendina, Domenico; Filippo, Gianpaolo De; Merlotti, Daniela; Stefano, Marco Di; Succoio, Mariangela; Muggianu, Simona Maria; Bianciardi, Simone; D’Elia, Lanfranco; Coppo, Eleonora; Faraonio, Raffaella; Nuti, Ranuccio; Strazzullo, Pasquale; Gennari, Luigi

doi:10.1007/s00223-019-00578-1

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…Indeed, hypovitaminosis D is common in Italy, as recently confirmed by cohort studies in the general population as well as in patients with metabolic bone disorders [ 41 ]. In this respect, a condition of vitamin D deficiency in the Italian population was recently defined for serum 25OHD values <20 ng/mL (50 nmol/L); however, maintaining levels above 30 ng/mL (75 nmol/L) in risk categories, as well as in patients under treatment with antiresorptive or bone osteo-anabolic drugs, has been recommended [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 92%

Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

et al. 2023

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Vitamin D plays a crucial role in calcium and phosphate metabolism, relating to bone health and preventing metabolic bone disorders such as rickets and osteomalacia. Vitamin D deficiency (serum 25-OH-D values <20 ng/mL or 50 nmol/L) is common also in Italian people; it is recommended to maintain levels above 30 ng/mL (75 nmol/L) in categories at risk. Supplementation and/or fortification with either ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) aimed to modify this condition have commonly been proposed. Studies about vitamin D intake are numerous in the literature but not adequately designed and are very often incomplete in Mediterranean Countries such as in the Italian population. On these bases, we performed a survey to validate a frequency food questionnaire (FFQ) specifically created to rapidly assess dietary vitamin D intake in Italian people. For this aim, the data of questionnaires were compared with results derived in the same population from a designed 14-day frequency food diary (FFD). Overall, a good correlation between FFQ and FFD was observed (r = 0.89, p < 0.001), both demonstrating a remarkably low vitamin D intake, irrespective of age and gender. Our data confirm that the vitamin D intake is very low in Italy, which likely contributes to hypovitaminosis D.

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Section: Discussionmentioning

confidence: 92%

Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

et al. 2023

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“…Noteworthy, a Cochrane meta-analysis did not indicate an increased risk of hypercalcemia, hypercalciuria or nephrolithiasis in patients with vitamin D deficiency treated with cholecalciferol [119]. Moreover, the correction of vitamin D deficiency with cholecalciferol in patients with Paget's disease of the bones, who are at increased risk of nephrolithiasis [120], did not cause either an increase in supersaturation indices of calcium-oxalate and calcium-phosphate salts or a rise in urinary pH and urinary excretion of urate, the major risk factors for calcium and urate nephrolithiasis, respectively [121].…”

Section: Modifiable Risk Factorsmentioning

confidence: 98%

Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?

Rendina

Filippo

Iannuzzo

et al. 2020

IJMS

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Idiopathic osteoporosis and nephrolithiasis are formidable health problems showing a progressive increase in their incidence and prevalence in the last decades. These temporal trends were observed in both pediatric and adult populations worldwide. Epidemiological and experimental studies indicate that both disorders show several common pathogenic environmental and genetic factors. In this review, we analyzed the clinical characteristics common to the two disorders and the state-of-the-art knowledge regarding the genetic predisposition and the environmental factors recognized as triggers in adult and pediatric ages. As a result of this work, we propose to consider idiopathic nephrolithiasis and osteoporosis as two possible expressions of a unique clinical syndrome. Accordingly, the clinical approach to both disorders should be modified in order to program an efficient primary and secondary prevention strategy.

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“…The risk of vitamin D deficiency (either considering the 10 ng/mL or the 20 ng/mL threshold) is particularly high in Italy, as recently confirmed by cohort studies in the general population as well as in patients with metabolic bone disorders [ 10 ], thus mirroring the North-South gradient of vitamin D levels described among European countries, despite the wide use of supplements [ 11 ]. This implies an important attention to its possible clinical consequences and the need for action deriving from the wide prevalence of hypovitaminosis D and the cost-efficacy concerns related to the measurement of serum vitamin D levels and vitamin D supplementation [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 87%

Definition, Assessment, and Management of Vitamin D Inadequacy: Suggestions, Recommendations, and Warnings from the Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS)

Bertoldo

Cianferotti

Monaco³

et al. 2022

Nutrients

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In the recent years, both the prescriptions of serum 25(OH)D levels assay, and vitamin D supplementation are constantly increasing, as well as the costs to be incurred relating to these specific aspects. As in many other countries, the risk of vitamin D deficiency is particularly high in Italy, as recently confirmed by cohort studies in the general population as well as in patients with metabolic bone disorder. Results confirmed the North-South gradient of vitamin D levels described among European countries, despite the wide use of supplements. Although vitamin D supplementation is also recommended by the Italian Medicine Agency for patients at risk for fragility fracture or for initiating osteoporotic medication, the therapeutic gap for osteoporosis in Italy is very high. There is a consistent proportion of osteoporotic patients not receiving specific therapy for osteoporosis following a fragility fracture, with a poor adherence to the recommendations provided by national guidelines and position paper documents. The failure or inadequate supplementation with vitamin D in patients on antiresorptive or anabolic treatment for osteoporosis is thought to further amplify the problem and exposes patients to a high risk of re-fracture and mortality. Therefore, it is important that attention to its possible clinical consequences must be given. Thus, in light of new evidence from the literature, the SIOMMMS board felt the need to revise and update, by a GRADE/PICO system approach, its previous original recommendations about the definition, prevention, and treatment of vitamin D deficiency in adults, released in 2011. Several key points have been here addressed, such as the definition of the vitamin D status: normality values and optimal values; who are the subjects considered at risk of hypovitaminosis D; opportunity or not of performing the biochemical assessment of serum 25(OH)D levels in general population and in subjects at risk of hypovitaminosis D; the need or not to evaluate baseline serum 25(OH)D in candidate subjects for pharmacological treatment for osteoporosis; how and whether to supplement vitamin D subjects with hypovitaminosis D or candidates for pharmacological treatment with bone active agents, and the general population; how and whether to supplement vitamin D in chronic kidney disease and/or chronic liver diseases or under treatment with drugs interfering with hepatic metabolism; and finally, if vitamin D may have toxic effects in the subject in need of supplementation.

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Vitamin D Status in Paget Disease of Bone and Efficacy–Safety Profile of Cholecalciferol Treatment in Pagetic Patients with Hypovitaminosis D

Cited by 12 publications

References 43 publications

Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

Dietary Vitamin D Intake in Italian Subjects: Validation of a Frequency Food Questionnaire (FFQ)

Idiopathic Osteoporosis and Nephrolithiasis: Two Sides of the Same Coin?

Definition, Assessment, and Management of Vitamin D Inadequacy: Suggestions, Recommendations, and Warnings from the Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS)

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