Epidemiological and molecular mechanisms aspects linking obesity and cancer

Osório–Costa, Felipe; Rocha, George J. M.; Dias, Milton; Carvalheira, José Barreto Campello

doi:10.1590/s0004-27302009000200013

Cited by 59 publications

(51 citation statements)

References 100 publications

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“…However, for the association between the overweight and GBC risk, the pooled RR was 1. Both in developed countries and developing countries, obesity was considered to be a major public health challenge in men and women (70). A previous quantitative review by Polednak (71) showed the trends in estimated population attributable risk percent of GBC due to obesity.…”

Section: Obesitymentioning

confidence: 99%

Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta‐analysis of observational studies

Gan

et al. 2016

Obesity

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Objective: Epidemiological studies have repeatedly investigated the association between excess body weight and the risk of biliary tract cancer with inconsistent results. The objective of this study was to quantitatively assess the associations between overweight and obesity and the risk of biliary tract cancer. Methods: A comprehensive search of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases up to August 2015 was conducted, and the reference lists of retrieved articles for additional relevant studies were manually searched. Results: Fourteen prospective cohort studies and 15 case-control studies were included in this metaanalysis. These studies included 11,448,397 participants (6,733 patients with gallbladder cancer [GBC] and 5,798 patients with extrahepatic bile duct cancer [EBDC]) with follow-up durations ranging from 5 to 23 years. Among overweight adults, the pooled RR was 1.17 (95% CI, 1.07-1.28) for GBC and 1.26 (95% CI, 1.14-1.39) for EBDC, and among people with obesity, the pooled RR was 1.62 (95% CI, 1.49-1.75) for GBC and 1.48 (95% CI, 1.21-1.81) for EBDC. Visual inspection of the funnel plots and the Begg's and the Egger's tests did not show enough evidence of publication bias. Conclusions: Integrated evidence from this meta-analysis suggests that excess body weight is associated with a significantly increased risk of GBC and EBDC.

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Section: Obesitymentioning

confidence: 99%

Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta‐analysis of observational studies

Gan

et al. 2016

Obesity

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“…According to this review, MLT levels are regulated by ipRGCs, which control the inhibition of the pineal hormone in response to short wavelength ALAN and consequently advance tumorigenesis mediated by epigenetic modification, such as DNA methylation. Considering the suggested association between obesity and the development of variant cancers [220], the suggested nexus between ALAN, MLT suppression, epigenetic modifications, and adverse health consequences [219] is of significant clinical importance.…”

Section: Mlt and Epigenetic Modificationsmentioning

confidence: 99%

Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity

Zubidat

Haim

2017

Journal of Basic and Clinical Physiology and Pharmacology

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Both obesity and breast cancer are already recognized worldwide as the most common syndromes in our modern society. Currently, there is accumulating evidence from epidemiological and experimental studies suggesting that these syndromes are closely associated with circadian disruption. It has been suggested that melatonin (MLT) and the circadian clock genes both play an important role in the development of these syndromes. However, we still poorly understand the molecular mechanism underlying the association between circadian disruption and the modern health syndromes. One promising candidate is epigenetic modifications of various genes, including clock genes, circadian-related genes, oncogenes, and metabolic genes. DNA methylation is the most prominent epigenetic signaling tool for gene expression regulation induced by environmental exposures, such as artificial light-at-night (ALAN). In this review, we first provide an overview on the molecular feedback loops that generate the circadian regulation and how circadian disruption by ALAN can impose adverse impacts on public health, particularly metabolic disorders and breast cancer development. We then focus on the relation between ALAN-induced circadian disruption and both global DNA methylation and specific loci methylation in relation to obesity and breast cancer morbidities. DNA hypo-methylation and DNA hyper-methylation, are suggested as the most studied epigenetic tools for the activation and silencing of genes that regulate metabolic and monostatic responses. Finally, we discuss the potential clinical and therapeutic roles of MLT suppression and DNA methylation patterns as novel biomarkers for the early detection of metabolic disorders and breast cancer development.

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“…Düşük adiponektin düzeylerine BHK'lı hastalarda sağlıklı insanlara göre daha sık rastlanmaktadır. Obezite ile inflamasyon ve insulin direnci gelişmesi arasında bağlantılar bulunmuştur (24).…”

Section: Obeziteunclassified

Böbrek Hücreli Karsinomda Risk Faktörleri ve Etyoloji

Gül¹

2014

uob

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Böbrek Hücreli Karsinom (BHK) üçüncü en sık ürolojik kanser olup daha erken evrede tanı konulmasına rağmen halen yüksek mortalite oranları ile seyretmektedir. Görülme sıklığı gittikçe artmaktadır. Etyoloji ve risk faktörlerinin daha iyi tanımlanması için yapılan epidemiyolojik çalışmalar hastalığın gelişmesini önlemede alınacak önlemler konusunda bize yeni bilgiler sunacaktır. BHK'da bilinen en güçlü risk faktörleri tütün kullanımı, obezite, ve kan basıncı yüksekliğidir. İlaç kullanımı ile BHK arasında zayıf, diyet ve mesleki faktörler ile BHK arasında ise orta derecede güce sahip ilişki ortaya konulabilmiştir. Risk faktörlerinin daha güçlü kanıtlarla ortaya konulabilmesi daha etkin tedbirlerin alınmasını sağlayacaktır. Risk altındaki insanların belirlenerek gerekli bilgilendirilmelerin yapılması ve önlemlerin alınması ile BHK gelişme riskinde azalma hedeflenebilir. (Üroonkoloji Bülteni 2014;13:135-138) Anah tar Ke li me ler: Böbrek kanseri, risk faktörleri, tütün kullanımı Renal cell carcinoma (RCC) is the third most common urological carcinoma and has the highest mortality rate although it is diagnosed at the early stage. The incidence of RCC has been increasing. Epidemiological studies conducted to better clarify the etiology and risk factors will shed new light about protective measures in prevention. The strongest known risk factors related to RCC are tobacco smoking, obesity and high blood pressure. A weak correlation was found between medications and RCC and a moderate correlation was found between occupational and dietary factors and RCC. Establishing correlations with stronger proofs between risk factors and RCC might lead to more effective preventive measures. Identification of people under risk and informing them adequately and establishing protective measures may lead to a decrease in the risk of RCC development. (Bulletin of Urooncology 2014;13:135-138)

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Epidemiological and molecular mechanisms aspects linking obesity and cancer

Cited by 59 publications

References 100 publications

Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta‐analysis of observational studies

Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta‐analysis of observational studies

Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity

Böbrek Hücreli Karsinomda Risk Faktörleri ve Etyoloji

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