Avaliação da função pancreática em pacientes com diabetes melito tipo 1 de acordo com a duração da doença

Dantas, Joana Rodrigues; Almeida, Mirella Hansen de; Barone, Bianca; Campos, Felipe Lopes; Kupfer, Rosane; Milech, Adolpho; Zajdenverg, Lenita; Rodacki, Melanie; Oliveira, José Egídio Paulo de

doi:10.1590/s0004-27302009000100010

Cited by 3 publications

(5 citation statements)

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“…Based on our findings, we can consider that the lipoprotein damage observed in the group of infected pancreas may happen because of the destruction of pancreatic cells caused by endoparasitosis. Among pancreatic cells, β cells stand out, which are closely related to DM1 (Atkinson & Eisenbarth, 2001;Dantas et al, 2009;Sousa et al, 2016) and this pathological condition has already been related to physiological changes of parasitic origin (Gepts & Lecompte, 1981). The increase in antioxidant defenses observed in this study is triggered because of the body's natural balance to maintain the physiological homeostasis.…”

Section: Discussionmentioning

confidence: 60%

“…Insulin levels deficit causes hyperglycemia, which will cause problems in heart, kidney, neural problems, and etc. (Atkinson & Eisenbarth, 2001;Dantas et al, 2009;Sousa et al, 2016). Therefore, there is an urgent call for the study of DM1 pathophysiological mechanisms to mitigate its consequences.…”

Section: Discussionmentioning

confidence: 99%

“…Organic changes of parasitic origin found in humans and animals suggest the development of some pathological conditions, such as Diabetes Mellitus Type 1 (DM1) (Gepts & Lecompte, 1981;Capen, 2001). DM1 is a chronic disease characterized by progressive, immune-mediated destruction of pancreatic β cells islets with consequent insufficient insulin secretion (Atkinson & Eisenbarth, 2001;Dantas et al, 2009;Sousa et al, 2016). However, the occurrence of pathological conditions such as DM1 originated from parasitic infection is based on the literature only in the description of clinical, biochemical and pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

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Eurythrematosis as a developmental model of the Diabetes Mellitus type 1 pathological condition: pathophysiological parameters and oxidative stress / Eurytrematose como modelo de desenvolvimento da patologia da Diabetes Mellitus tipo 1: parâmetros fisiopatológicos e stress oxidativo

Rosa¹,

Nodari²,

Suthovski³

et al. 2021

BJDV

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Eurytrematosis is a helminthic disease caused by trematodes belonging to the genus Eurytrema spp. that parasitize the pancreas of many animals and humans. This parasitosis causes chronic fibrosing pancreatitis, fat infiltration in the pancreatic parenchyma, besides damaging the exocrine pancreas, which is similar to that found in patients with Diabetes Mellitus type 1 (DM1). The current work aimed to evaluate the use of bovine pancreas infected with E. coelomaticum as a model to study DM1 pathophysiology. It was carried out macroscopic analyses, parasite identification, total pancreatic lipid determination and oxidative damage biomarkers levels of pancreas naturally infected with E. coelomaticum. Macroscopically, we observed that the infected pancreas had duct obstruction, organ stiffness due to the visible presence of fibrosis, increased adipose tissue deposition, increased protein and lipid damage, as well as increased antioxidant biomarkers (GSH, CAT and VIT C). Thus, it is possible to show that DM1 may have pancreatic parasitism as a possible primary origin. However, more studies are needed to better investigate this possible primary origin; the results obtained here suggest that the use of pancreas parasitized by E. coelomaticum could be a model to investigate DM1 pathophysiology.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Eurythrematosis as a developmental model of the Diabetes Mellitus type 1 pathological condition: pathophysiological parameters and oxidative stress / Eurytrematose como modelo de desenvolvimento da patologia da Diabetes Mellitus tipo 1: parâmetros fisiopatológicos e stress oxidativo

Rosa¹,

Nodari²,

Suthovski³

et al. 2021

BJDV

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“…Os potenciais benefícios implicados à preservação do PC em pacientes com DM1 poderiam, ao menos em parte, estar relacionados a efeitos favoráveis no controle glicêmico (30). O DCCT demonstrou que a manutenção de alguma secreção de insulina no DM1 pode facilitar a obtenção de controle metabólico satisfatório e já é amplamente reconhecida a importância da manutenção da glicemia em níveis próximos da normalidade para redução dos riscos de complicações crônicas.…”

Section: Discussionunclassified

Implicações clínicas da persistência de anti-GAD positivo e peptídeo C detectável em pacientes com diabetes melito tipo 1 de longa duração

Serfaty

Dantas²,

Almeida

et al. 2010

Arq Bras Endocrinol Metab

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RESUMOObjetivo: Avaliar se anti-GAD positivo e PC detectável se correlacionam com a presença de outras doenças autoimunes, com controle glicêmico e com risco de retinopatia no diabetes melito tipo 1 (DMT1) > 3 anos de duração. Pacientes e métodos: Cinquenta sujeitos com DMT1 foram entrevistados, realizaram fundoscopia e dosaram PC pré e pós-glucagon, HbA1C e anti-GAD. Resultados: Pacientes anti-GAD+ (n = 17) apresentaram maior frequência de doenças autoimunes em relação aos demais (p = 0,02). PC detectável (n = 11) também foi associado ao aumento dessa prevalência (p = 0,03), porém nenhum dos dois parâmetros influenciou na presença de retinopatia diabética. PC detectável não influenciou no controle glicêmico (HbA1C média) (p = 0,28), porém as doses diárias de insulina foram mais baixas (0,62 vs. 0,91 U/kg/dia; p = 0,004) neste grupo. Conclusão: Apesar de não ser um marcador para outras doenças autoimunes, o anti-GAD+ parece ser não só um sinalizador de autoimunidade pancreática. PC detectável também parece ter papel promissor na detecção dessas comorbidades. Ambos não interferiram na presença de retinopatia, entretanto, o PC detectável se relacionou a menores necessidades de insulina. Arq Bras Endocrinol Metab. 2010;54(5):449-54 Descritores Diabetes melito tipo 1; peptídeo C; anti-GAD; secreção de insulina; doença autoimune ABSTRACT Objective: The aim of this study was to evaluate if GADA+ and detectable CP had any influence in other autoimmune diseases, glycemic control, and risks of retinopathy in diabetes mellitus type 1 (T1DM) lasting longer than 3 years of duration. Subjects and methods: Fifty T1DM subjects were interviewed, performed fundoscopic examination, and measured CP before and after glucagon, HbA1C, and GADA. Results: GADA+ (n = 17) had a higher frequency of other autoimmune diseases when compared to GADA (p = 0.02). Detectable CP was also associated with a higher prevalence of these diseases (p = 0.03), although, retinopathy was not influenced by either one. Detectable CP had no influence in the glycemic control (mean HbA1C) (p = 0.28). However, insulin daily doses were lower in this group (0.62 vs. 0.91 U/kg/day; p = 0.004). Conclusion: Although not recommend as a marker of other autoimmune diseases, GADA+ seems to be not only a pancreatic autoimmunity signal. Detectable CP may also have some promising influence in detecting these diseases. Neither influenced the presence of retinopathy, but insulin daily requirements were smaller when CP was present. Arq Bras Endocrinol Metab. 2010;54(5):449-54

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“…2 Cell destruction proceeds at an intense and rapid rate when the onset is during childhood or adolescence, which leads to early and constant treatment with insulin, whereas when it emerges in adulthood, the process is slower and patients may retain residual beta-cell function for some years after diagnosis. 3,4 The autoimmune nature of DM1 is caused by the presence of circulating autoantibodies, including islet cell autoantibodies (ICA), insulin autoantibodies (IAA) and anti-glutamic acid decarboxylase (GAD). 5 These markers, alone or in combination, are found in 85-90% of individuals with a recent diagnosis of DM1.…”

Section: Introductionmentioning

confidence: 99%

Frequency of the anti-glutamic acid decarboxylase immunological marker in patients with diabetes duration longer than three years in southern Brazil

et al. 2011

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CONTEXT AND OBJECTIVE: The anti-GAD (glutamic acid decarboxylase) antibody is considered to be an important marker for type 1 diabetes mellitus (DM1), with frequency that varies depending on the population studied and the duration of the disease. Therefore, the aim of this study was to determine the frequency of this autoantibody in a group of patients in southern Brazil with DM1 that had been diagnosed more than three years previously. DESIGN AND SETTING: Analytical cross-sectional study with a control group conducted at the Biomedicine Laboratory of Universidade Feevale. METHODS: This study was conducted between June 2007 and December 2008, and 109 individuals were enrolled during this period. Fifty-eight were DM1 patients and 51 were individuals free from DM1 and without any history of diabetes, who constituted the control group. RESULTS: In the DM1 group, the mean age was 27 ± 1.7 years and 50% were men. The mean fasting blood glucose in the DM1 group was 208 ± 15 mg/dl and mean HbA1c (glycosylated hemoglobin) was 8.7 ± 0.25%. In the control group, the mean fasting blood glucose and HbA1c were 82 mg/dl and 5.0% respectively. Thirty-seven individuals with DM1 (63.8%) were positive for anti-GAD, and this proportion was significantly larger than in the control group. CONCLUSIONS: These results show the high prevalence of anti-GAD in the population of diabetic patients in southern Brazil, thus indicating that the antibody was still present a long time after the disease had been diagnosed.

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Avaliação da função pancreática em pacientes com diabetes melito tipo 1 de acordo com a duração da doença

Cited by 3 publications

References 21 publications

Eurythrematosis as a developmental model of the Diabetes Mellitus type 1 pathological condition: pathophysiological parameters and oxidative stress / Eurytrematose como modelo de desenvolvimento da patologia da Diabetes Mellitus tipo 1: parâmetros fisiopatológicos e stress oxidativo

Eurythrematosis as a developmental model of the Diabetes Mellitus type 1 pathological condition: pathophysiological parameters and oxidative stress / Eurytrematose como modelo de desenvolvimento da patologia da Diabetes Mellitus tipo 1: parâmetros fisiopatológicos e stress oxidativo

Implicações clínicas da persistência de anti-GAD positivo e peptídeo C detectável em pacientes com diabetes melito tipo 1 de longa duração

Frequency of the anti-glutamic acid decarboxylase immunological marker in patients with diabetes duration longer than three years in southern Brazil

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