2008
DOI: 10.1590/s0004-27302008000100017
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Metformina e AMPK: um antigo fármaco e uma nova enzima no contexto da síndrome metabólica

Abstract: RESUMOA metformina é uma das drogas antidiabéticas orais mais prescritas mundialmente, entretanto seu mecanismo de ação permanece desconhecido. Os estudos do Diabetes Prevention Program Research Group demonstraram que tanto a administração de metformina como a mudança no estilo de vida (dieta e exercício físico) podem reduzir a incidência de diabetes melito tipo 2 (DM2). Uma possível conexão bioquímica entre essas duas terapias pode ser a proteína quinase ativada por AMP (AMPK). Essa enzima foi inicialmente de… Show more

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Cited by 26 publications
(13 citation statements)
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References 28 publications
(92 reference statements)
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“…A network of different factors is most likely responsible for its maintenance. The activated protein kinase (AMPK) forms a molecular hub for cellular metabolic control [122]. Recent studies of neuronal models are pointing to possible AMPK roles beyond energy sensing with some reporting protective effects [123] while others report detrimental effects, particularly under extreme energy depletion [124].…”
Section: Introductionmentioning
confidence: 99%
“…A network of different factors is most likely responsible for its maintenance. The activated protein kinase (AMPK) forms a molecular hub for cellular metabolic control [122]. Recent studies of neuronal models are pointing to possible AMPK roles beyond energy sensing with some reporting protective effects [123] while others report detrimental effects, particularly under extreme energy depletion [124].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, activation of the AMPK pathway is thought to play a role in reducing the insulin resistance and the oxidative stress. And, as mentioned earlier, metformin was found to accelerate the activation of the AMPK [1, 31]. Activation of AMPK by metformin could partly help in understanding the minor protective role of metformin in Alzheimer’s disease.…”
Section: Mechanism Of Action Of Metforminmentioning
confidence: 81%
“…But it is quite known that brain cells are dependent on the glucose for survival, as well as the high probability of oxidative injuries since they have low antioxidant enzymes content and frequent exposure to oxidative stresses [31, 32]. Moreover, activation of the AMPK pathway is thought to play a role in reducing the insulin resistance and the oxidative stress.…”
Section: Mechanism Of Action Of Metforminmentioning
confidence: 99%
“…Наиболее вероятно, что в его поддержании играет роль совокупность различных факторов. АМФ-активируемая протеинкиназа (АМФК) является сво-еобразным молекулярным центром в контроле клеточного метаболизма [3]. Недавние исследования на нейрональных моделях указывают на возможные дополнительные роли АМФК помимо контроля энергетического баланса клетки.…”
unclassified
“…АМФК активируется в мозге при метаболических стрес-сах, которые подавляют образование аденозинтрифосфата (АТФ), таких как, например, ишемия, гипоксия, гипоглике-мия, прием ингибиторов метаболизма (метформин), а также при катаболических и АТФ-затратных процессах [3].…”
unclassified