Sobrepeso na adolescência de filhos de mães que tiveram distúrbios glicêmicos na gestação

Buzinaro, Elizabeth F.; Berchieri, Carolina Bragiola; Haddad, Antônio; Padovani, Carlos Roberto; Pimenta, Walkyria de Paula

doi:10.1590/s0004-27302008000100012

Cited by 16 publications

(4 citation statements)

References 25 publications

(32 reference statements)

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“…The interaction of metabolic syndrome with the female reproductive life cycle is discussed in five papers highlighted here: Buzzinaro et al 19 reported on the incidence of high body mass index scores in adolescent offspring among the children of mothers with hyperglycemia during pregnancy, adding that such patients should be followed from childhood. Rivera et al 20 evaluated the association between pubertal gynecomastia and body mass index and concluded that a significant correlation occurs between pubertal gynecomastia and a higher body mass index in adult life.…”

Section: Methodsmentioning

confidence: 99%

Metabolic and infectious pathologies in Brazilian medical literature: a review

Rocha-e-Silva¹

2010

Clinics

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OBJECTIVE: This review of original reports on metabolic and infectious diseases that were recently published in Brazilian journals is designed to inform the readership of CLINICS about their content.METHODS: I conducted a search in PubMed for original research articles (clinical or basic research) recently published (2008)(2009) by Brazilian medical and biological periodicals. Papers on metabolic pathologies were retrieved by searching for appropriate keywords such as metabolic syndrome and obesity. Papers on infectious disease were obtained by entering 15 different keywords for the most commonly occurring pathologies. Review articles, editorials, letters to the editor, and case reports were manually excluded. Selected titles were then categorized into appropriate sub-categories. RESULTS:This search produced a total of 123 articles, which filtered down to 72 articles after eliminating editorials, review articles, letters to the Editor and case reports.

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Section: Methodsmentioning

confidence: 99%

Metabolic and infectious pathologies in Brazilian medical literature: a review

Rocha-e-Silva¹

2010

Clinics

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“…Offspring born to GDM mothers with fasting and daily hyperglycemia have higher birth-weight and are frequently overweight in adolescence [44]. Compared with offspring of healthy mothers, offspring of type 2 diabetic mothers show decreased insulin sensitivity in adulthood even in the absence of IGT [45].…”

Section: Pregnancy Glycemia and Insulinemiamentioning

confidence: 99%

Nutrition During Pregnancy and the Effect of Carbohydrates on the Offspring’s Metabolic Profile: In Search of the “Perfect Maternal Diet”

Tzanetakou

Mikhailidis²,

Perrea³

2011

TOCMJ

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Fetal growth and development is primarily dependent upon the nutritional, hormonal and metabolic environment provided by the mother. A wartime famine study in Holland first showed that a low food intake reduces the glucose offered to the fetus and thus produces smaller size infants at birth. Maternal glucose regulation is however affected by numerous factors including physiological changes of pregnancy (e.g. insulin resistance [IR]), pathological conditions (e.g. gestational diabetes mellitus) and maternal nutrition. Maternal glucose is substantially influenced by the type of carbohydrates in the diet through its direct effect on glycemia. The rate at which each carbohydrate raises blood glucose levels after ingestion, can be measured via the dietary glycemic index (GI). Carbohydrate type and the GI of the diet enhance or inhibit abnormal hyperglycemia during pregnancy caused by either pathological conditions or the inability of the mother to cope with the physiological IR of pregnancy. In turn, maternal gestational hyperglycemia may be involved in the pathogenesis of IR, impaired glucose tolerance, type 2 diabetes mellitus, the Metabolic Syndrome and subsequent cardiovascular diseases in adult offspring. A low GI maternal diet has been associated with measurable benefits to the offspring. These include a positive effect on altering maternal blood glucose production, insulinemia and reduced adiposity as well as fetal and placental insulin and glucose regulation, fetal growth, birth weight and offspring adiposity. We review the possible links between dietary carbohydrate in health during pregnancy and the effect of maternal carbohydrate ingestion on programming the offspring’s metabolic profile.

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“…Therefore, the intrauterine environment can modulate one's adult life, regardless of genomic coding. This reasoning is the basis of the theory known as intrauterine programming [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Gestational and Previous Diabetes in Pregnancy: Perinatal Results

Ja¹,

Gqa²,

Pm³

et al. 2020

Asp Biomed Clin Case Rep

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Objective: Evaluating the association between gestational diabetes and fetal/maternal complications such as poor obstetric outcomes. Methods: Historical cohort comprising patients from the High-Risk Service of Federal University of Juiz de Fora (UFJF,) who were diagnosed with diabetes (exposed), as well as patients from the Low-Risk Service of UFJF (non-exposed). Data generated through anamnesis, physical examination and medical conduct, as well as data of newborns such as fetal weight, ICU admission and fetal/neonatal death), were collected and stored in the Epi Info software (version 6.0); p < 0.05. Results: 176 patients treated in the aforementioned services, 108 diabetic, and 68 non-diabetics, were investigated in the current study. In total, 92 (52.2%) of them were diagnosed with Gestational Diabetes Mellitus (GDM); 6 had DM type 1 (3.4%) and 10 had DM type 2 (5.6%). Therefore, 68 patients (38.6%) presented normal glucose metabolism. The mean age of the patients was 30.27 ± 6.77 years, the mean number of births was 1.06 ± 1.20. Macrosomia was diagnosed in 6.81% (n = 6) of the cases; it was associated with maternal glycemia (p < 0.05). D- and F-class pregnant women, who had been previously diagnosed with diabetes, presented lower fetal weight than other pregnant women (p = 0.03). Treatment was based on diet, insulin or metformin, whenever necessary. Fasting glycemia levels decreased throughout the gestational trimesters. Eighteen (10.2%) preterm fetuses were identified; 12 were born from diabetic mothers and 6 were born from non-diabetic ones (p = 0.01; X2 = 10.51). All infants hospitalized in the neonatal ICU (n = 10) were born from diabetic mothers; their mean gestational age was 36.28 + 2.9 weeks, whereas the mean gestational age of infants who were not hospitalized in the ICU was 38.31 ± 1.5 (p = 0.005; T = 12.58). Cesarean section was the most common way of delivery adopted for diabetic pregnant women (p = 0.04). Conclusion: Based on the results, gestational diabetes (GDM) is a predisposing factor to fetal macrosomia, prematurity, and hospitalization in neonatal ICUs. Pregnant women subjected to proper glycemic control in the current study presented lower complication rates in comparison to other studies in the literature.

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Sobrepeso na adolescência de filhos de mães que tiveram distúrbios glicêmicos na gestação

Cited by 16 publications

References 25 publications

Metabolic and infectious pathologies in Brazilian medical literature: a review

Metabolic and infectious pathologies in Brazilian medical literature: a review

Nutrition During Pregnancy and the Effect of Carbohydrates on the Offspring’s Metabolic Profile: In Search of the “Perfect Maternal Diet”

Gestational and Previous Diabetes in Pregnancy: Perinatal Results

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