Desenvolvimento de um método para a determinação da iodúria e sua aplicação na excreção urinária de iodo em escolares brasileiros

Esteves, Roberto Zonato; Kasamatsu, Teresa S.; Kunii, Ilda S.; Furuzawa, Gilberto K.; Vieira, José Gilberto H.; Maciel, Rui M. B.

doi:10.1590/s0004-27302007000900010

Cited by 23 publications

(10 citation statements)

References 16 publications

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“…Apesar das manifestações clínicas mais extremas como o bócio e o cretinismo endêmicos serem mais evidentes em regiões de acentuada carência de iodo, a prevalência de alterações mais sutis como hipotireoidismo subclínico, baixo rendimento escolar, aumento da mortalidade perinatal e infantil e estagnação socioeconômica ARTIGO ARTICLE tendem a ser subavaliadas quando a deficiência é leve ou moderada 3,4 .…”

Section: Introductionunclassified

Deficiência de iodo e fatores associados em lactentes e pré-escolares de um município do semiárido de Minas Gerais, Brasil, 2008

et al. 2012

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The aim of this study was to evaluate the prevalence of iodine deficiency in children aged 6 to 71 months in Novo Cruzeiro, Minas Gerais State, Brazil. A total of 475 children, allocated by stratified probability sampling, were analyzed with respect to the iodine concentrations in the salt consumed by the family and urinary iodine. Iodine deficiency was verified in 34.4% of the children, of which 23.5% showed slight deficiency, 5.9% moderate and 5% serious deficiency. A difference in the distribution of iodine deficiency was observed between the urban and the rural environments (p < 0.001) where average urinary iodine concentrations of 150.8 and 114.3µg/L respectively were found. A greater proportion of iodine deficiency was observed among children where the proportion of iodine in the salt consumed was below the recommended level. Although expressive, iodine deficiency in Novo Cruzeiro is not a public health problem according to World Health Organization (WHO), The limitrophe distribution of the urinary iodine associated with low iodine levels in salt suggests that efforts to control this deficiency are not yet complete.

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Section: Introductionunclassified

Deficiência de iodo e fatores associados em lactentes e pré-escolares de um município do semiárido de Minas Gerais, Brasil, 2008

et al. 2012

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“…A few Brazilian studies [22,43,44] have shown iodine sufficiency in the general population and a study conducted in Region A [21] also came to a similar conclusion. The average urine iodine was 26.5 μg/dL (reference values ranging from 10–30 μg/dL) in Region A and iodine concentration in table salt consumed in the same region was 31.9 mg/kg which lies within the acceptable limits of 20–60 mg/kg, suggesting that environmental factors are the most plausible cause of the reported results of our study.…”

Section: Discussionmentioning

confidence: 67%

“…Tests for A-Tg and A-TPO were performed because in iodine sufficient regions, CAT is the major cause of PH [10]. Iodine sufficiency for Region A was demonstrated in previous studies [21,22,23]. All patients selected for this study were diagnosed with CAT and all patients were positive for antibodies to thyroglobulin and to thyroperoxidase.…”

Section: Methodsmentioning

confidence: 99%

Overt Primary Hypothyroidism in an Industrial Area in São Paulo, Brazil: The Impact of Public Disclosure

Zaccarelli-Marino

André

Singer

2016

IJERPH

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Abstract:Background: Primary hypothyroidism (PH) is the most common thyroid pathology. Purpose: to evaluate the impact of public disclosure of an unexpected number of PH cases on the frequency of patients seeking medical evaluation for endocrinological diseases. Methods: data on 6306 subjects (3356 living in the surroundings of a petrochemical complex and 2950 in a control region) were collected over a 15-year time span. Thyroid function was determined by serum levels of triiodothyronine, thyroxine, free thyroxine and thyrotrophin. Antithyroglobulin and antithyroperoxidase antibodies and sonographic scans of the thyroid were performed in all patients. The data were analyzed via log-linear models to compute odds and odds ratios. Results: An increasing trend in the odds of PH was detected along the observation period with greater slope in the study region than in the control region. The odds of PH in the post-disclosure period (2002 to 2004) are greater than the corresponding ones in the pre-disclosure period (1989 to 2001). Conclusions: This study shows that living in the surroundings of a petrochemical complex may be an important risk factor for PH for both adults and children. Furthermore, public disclosure of such risk factor contributes to the awareness of the problem and to the possibility of an early diagnosis.

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“…The urinary iodine was determined using the Sandell-Kolthoff method [13] [14]. The method is based on the catalytic role of iodine in the reduction of cerium ion to the cerous ion coupled with the oxidation of arsenite [15].…”

Section: Methodsmentioning

confidence: 99%

Iodine Malnutrition and Associated Factors in Schoolchildren Aged 6 to 14 Years in a Municipality Situated in the Semi-Arid Region of the State of Minas Gerais, Brazil, 2008

Macedo¹,

Teixeira²,

Bonomo³

et al. 2014

FNS

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The objective of this study was to assess the prevalence of iodine deficiency and possible correlated factors among schoolchildren in the municipality of Novo Cruzeiro-MG by means of an evaluation of urinary iodine excretion. Five hundred and forty schoolchildren aged 6 to 14 years selected by stratified sampling, were evaluated. Urine samples were analyzed using the SandellKolthoff method preconized by the WHO and iodine concentrations in the salt were assessed by means of volumetric analysis, in accordance with recommendations from the Ministry of Health. Iodine deficiency was observed in 38.9% of the schoolchildren. Of these, 28.7% of them presented slight deficiency, 6.2% of them were moderately deficient and 4% of them were seriously deficient. Median urinary iodine levels in the urban and rural population were 150.8 and 119.2 µg/L, respectively, with a clear distribution of iodine deficiency among the populations (p < 0.001) being registered. It was also observed that there was a high prevalence of deficient urinary iodine excretion among schoolchildren that consumed salt with an insufficient iodine content. In relation to M. de Souza Macedo et al. 2009 the quality of the salt consumed by families, in 12.2% of the residences studied the iodine content in salt was below the recommended level (20 mg/kg), while the iodine content was below 15 mg/kg in only 5.3% of them. The results indicated that, although not characterized as a public health issue, according to WHO criteria, iodine deficiency showed very high prevalence among schoolchildren in this region. Regarding the iodine content of salt found in household consumption, our findings indicated the National Program of Salt Iodination was not efficient in the city, since it did not hit the target proposed by the Ministry of Health. Furthermore, low urinary iodine excretion associated with the consumption of salt with low iodine content suggests the need for periodical evaluations in order to provide effective control of the endemic disease.

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Desenvolvimento de um método para a determinação da iodúria e sua aplicação na excreção urinária de iodo em escolares brasileiros

Cited by 23 publications

References 16 publications

Deficiência de iodo e fatores associados em lactentes e pré-escolares de um município do semiárido de Minas Gerais, Brasil, 2008

Deficiência de iodo e fatores associados em lactentes e pré-escolares de um município do semiárido de Minas Gerais, Brasil, 2008

Overt Primary Hypothyroidism in an Industrial Area in São Paulo, Brazil: The Impact of Public Disclosure

Iodine Malnutrition and Associated Factors in Schoolchildren Aged 6 to 14 Years in a Municipality Situated in the Semi-Arid Region of the State of Minas Gerais, Brazil, 2008

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