A microcirculação no diabetes: implicações nas complicações crônicas e tratamento da doença

Aguiar, Luiz Guilherme Kraemer de; Villela, Nivaldo Ribeiro

doi:10.1590/s0004-27302007000200009

Cited by 15 publications

(10 citation statements)

References 56 publications

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“…Diabetes mellitus (DM) is a metabolic disorder resulting from deficiency in insulin secretion, insulin action, or both, promoting disturbance of carbohydrate, fat and protein metabolism. Longterm complications of diabetes mellitus include retinopathy, nephropathy, neuropathy, microangiopathy and increased risk of cardiovascular disease (1,4,5).…”

Section: Introductionmentioning

confidence: 99%

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

et al. 2012

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-Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases. Plants are an important source of chemical constituents with potential for inhibition of α-amylase and can be used as therapeutic or functional food sources. A review about crude extracts and isolated compounds from plant source that have been tested for α-amylase inhibitory activity has been done. The analysis of the results shows a variety of crude extracts that present α-amylase inhibitory activity and some of them had relevant activity when compared with controls used in the studies. Amongst the phyto-constituents that have been investigated, flavonoids are one of them that demonstrated the highest inhibitory activities with the potential of inhibition related to number of hydroxyl groups in the molecule of the compound. Several phyto-constituents and plant species as α-amylase inhibitors are being reported in this article. Majority of studies have focused on the anti-amylase phenolic compounds.

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Section: Introductionmentioning

confidence: 99%

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

et al. 2012

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“…Resistance of cells towards insulin acceptability leads to the abnormal hike in the glucose level with the outcome of postprandial hyperglycemia [3,4]. Diabetes is a single disease with myriad negative side effects that is followed by impairment of functions of kidney, heart, eye and nervous system affecting carbohydrate, protein and fat metabolism [5][6][7]. This multifactorial disease needs in time attention to ameliorate the negative effects of the disease with proper administration of antidiabetic medicines like insulin, sulfonylureas, biguanide, glucosidase inhibitors, aldose reductase inhibitor, thiazolidinediones and insulin like growth factor.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Porcine Pancreatic Amylase Activity by Sulfamethoxazole: Structural and Functional Aspect

et al. 2016

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Combating Type-2 diabetes mellitus is a pivotal challenge in front of the present world. Several lines of therapy are in practice for resisting this deadly disease which often culminates with cardiovascular complexities, neuropathy and retinopathy. Among various therapies, administration of alpha glucosidase inhibitors is common and widely practiced. Sulfonylurea category of anti diabetic drug often suffers from cross reactivity with sulfamethoxazole (SMX), a common drug in use to treat a handful of microbial infections. However the specific cellular target generating postprandial hypoglycemia on SMX administration is till date unraveled. The present work has been initiated to elucidate the effects of a group of sulfonamide drugs inclusive of SMX for their amylase inhibitory role. SMX inhibits porcine pancreatic amylase (PPA) in a noncompetitive mode with an average IC50 value 0.94 mM respectively. Interaction of SMX with PPA is manifested with gradual quenching of tryptophan fluorescence with concomitant shift in lambda max value (λmax). Binding is governed by entropy driven factor (24.8 cal mol(-1) K(-1)) with unfavorable contribution from enthalpy change. SMX interferes with the activity of acarbose in a synergistic mode to reduce the effective dose of acarbose as evident from the in vitro PPA inhibition study. In summary, loss of PPA activity in presence of SMX is indicative of structural changes of PPA which is further augmented in the presence of acarbose as explained in the schematic model and docking study.

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“…The microcirculation represents a unique environment that acts as the site of gas and nutrient exchange between blood and tissues 1. Microvessel networks are often idealized as a set of vessels of different categories that are connected in a series with the parallel vessels in each category exhibiting identical properties 1.…”

Section: Introductionmentioning

confidence: 99%

“…Microvessel networks are often idealized as a set of vessels of different categories that are connected in a series with the parallel vessels in each category exhibiting identical properties 1. In reality, however, the structures of microvessel networks are highly heterogeneous.…”

Section: Introductionmentioning

confidence: 99%

Vimentin and laminin are altered on cheek pouch microvessels of streptozotocin-induced diabetic hamsters

Silva

Cyrino

Breitenbach

et al. 2011

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OBJECTIVES:Normal endothelial cells respond to shear stress by elongating and aligning in the direction of fluid flow. Hyperglycemia impairs this response and contributes to microvascular complications, which result in deleterious effects to the endothelium. This work aimed to evaluate cheek pouch microvessel morphological characteristics, reactivity, permeability, and expression of cytoskeleton and extracellular matrix components in hamsters after the induction of diabetes with streptozotocin.METHODS:Syrian golden hamsters (90–130 g) were injected with streptozotocin (50 mg/kg, i.p.) or vehicle either 6 (the diabetes mellitus 6 group) or 15 (the diabetes mellitus 15 group) days before the experiment. Vascular dimensions and density per area of vessels were determined by morphometric and stereological measurements. Changes in blood flow were measured in response to acetylcholine, and plasma extravasation was measured by the number of leakage sites. Actin, talin, α-smooth muscle actin, vimentin, type IV collagen, and laminin were detected by immunohistochemistry and assessed through a semiquantitative scoring system.RESULTS:There were no major alterations in the lumen, wall diameters, or densities of the examined vessels. Likewise, vascular reactivity and permeability were not altered by diabetes. The arterioles demonstrated increased immunoreactivity to vimentin and laminin in the diabetes mellitus 6 and diabetes mellitus 15 groups.DISCUSSION:Antibodies against laminin and vimentin inhibit branching morphogenesis in vitro. Therefore, laminin and vimentin participating in the structure of the focal adhesion may play a role in angiogenesis.CONCLUSIONS:Our results indicated the existence of changes related to cell–matrix interactions, which may contribute to the pathological remodeling that was already underway one week after induction of experimental diabetes.

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A microcirculação no diabetes: implicações nas complicações crônicas e tratamento da doença

Cited by 15 publications

References 56 publications

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

Inhibition of Porcine Pancreatic Amylase Activity by Sulfamethoxazole: Structural and Functional Aspect

Vimentin and laminin are altered on cheek pouch microvessels of streptozotocin-induced diabetic hamsters

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