Osteonecrosis in patients with acquired immunodeficiency syndrome (AIDS): report of two cases and review of the literature

Lima, Giovanna Aparecida Balarini; Verdeal, Juan Carlos Rosso; Farias, Maria Lúcia Fleiuss

doi:10.1590/s0004-27302005000600022

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…A prevalência da diminuição da densidade mineral óssea em adultos infectados pelo HIV tem sido de 22%-50% de adultos com osteopenia e 3%-21% com osteoporose 24 .…”

Section: Osteopenia E Osteoporoseunclassified

Abordagem metabólica e nutricional da lipodistrofia em uso da terapia anti-retroviral

Dutra

Libonati

2008

Rev. Nutr.

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A terapia anti-retroviral altamente ativa, usada contra o Vírus da Imunodeficiência Humana, vem possibilitando a melhora do quadro clínico-laboratorial de portadores da Síndrome da Imunodeficiência Adquirida. Contudo, alterações metabólicas e complicações morfológicas, associadas ao uso da terapia, vêm sendo investigadas. A utilização prolongada desta terapia tem um impacto importante sobre o estado nutricional dos pacientes. Antes da sua utilização, a perda de peso e a desnutrição, conseqüências das infecções oportunistas, eram os maiores problemas nutricionais. Atualmente, o foco principal das discussões têm sido as complicações metabólicas e morfológicas, dentre elas a lipodistrofia, com a dislipidemia, a resistência à insulina, a osteopenia, e a distribuição alterada da gordura corporal, aumentando assim os riscos de doenças cardiovasculares. A nutrição desempenha um papel fundamental no suporte da saúde desses pacientes, integrando as equipes multiprofissionais, promovendo a melhora da adesão à terapia anti-retroviral e do prognóstico da doença. No entanto, para que se tenha mais conhecimento sobre a terapia, as proporções de seus efeitos adversos, e o perfil nutricional desses pacientes, a curto e a longo prazos, é de suma importância que se estude mais sobre este assunto, a fim de permitir perspectivas de um regime terapêutico mais seguro dentro de seus alcances metodológicos, proporcionando uma melhor qualidade de vida aos pacientes. Termos de indexação:Lipodistrofia. Nutrição. Terapia anti-retroviral de alta atividade. A B S T R A C T

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“…A prevalência da diminuição da densidade mineral óssea em adultos infectados pelo HIV tem sido de 22%-50% de adultos com osteopenia e 3%-21% com osteoporose 24 .…”

Section: Osteopenia E Osteoporoseunclassified

Abordagem metabólica e nutricional da lipodistrofia em uso da terapia anti-retroviral

Dutra

Libonati

2008

Rev. Nutr.

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“…Increased pressure within the bone represents another causative factor, leading to the narrowing of blood vessels and reducing the blood supply to the bone tissue, resulting in osteonecrosis. Other factors contributing to this condition include radiation therapy, chemotherapy, kidney transplantation, organ transplantation, cancer, lupus erythematosus, blood diseases, acquired immune de ciency syndrome, osteoarthritis, osteoporosis, Gaucher's disease, and Caisson disease [16][17][18][19][20][21][22]. Symptoms of osteonecrosis pose challenges in early detection, with joint pain intensifying gradually as the disease advances.…”

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confidence: 99%

Proteomic Profiling of Extracellular Vesicles Derived from Human Serum for the Discovery of Biomarkers in Avascular Necrosis

Sung,

Lim,

Kang

et al. 2024

Preprint

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Background Avascular necrosis (AVN) is a medical condition characterized by the destruction of bone tissue due to a diminished blood supply. When the rate of tissue destruction surpasses the rate of regeneration, effective treatment becomes challenging, leading to escalating pain, arthritis, and bone fragility as the disease advances. A timely diagnosis is imperative to prevent and initiate proactive treatment for osteonecrosis. We explored the potential of differentially expressed proteins in serum-derived extracellular vesicles (EVs) as biomarkers for AVN of the femoral head in humans. We analyzed the genetic material contained in serum-derived exosomes from patients for early diagnosis, treatment, and prognosis of avascular necrosis. Methods EVs were isolated from the serum of both patients with AVN and a control group of healthy individuals. Proteomic analyses were conducted to compare the expression patterns of these proteins by proteomic analysis using LC-MS/MS. Results Our results show that the levels of IGHV3-23, FN1, VWF, FGB, PRG4, FCGBP, and ZSWIM9 were upregulated in the EVs of patients with AVN compared with those of healthy controls. ELISA results showed that VWF and PRG4 were significantly upregulated in the patients with AVN. Conclusions These findings suggest that these EV proteins could serve as promising biomarkers for the early detection and diagnosis of AVN. Early diagnosis is paramount for effective treatment, and the identification of new osteonecrosis biomarkers is essential to facilitate swift diagnosis and proactive intervention. Our study provides novel insights into the identification of AVN-related biomarkers that can enhance clinical management and treatment outcomes

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Osteonecrosis in patients with acquired immunodeficiency syndrome (AIDS): report of two cases and review of the literature

Cited by 2 publications

References 19 publications

Abordagem metabólica e nutricional da lipodistrofia em uso da terapia anti-retroviral

Abordagem metabólica e nutricional da lipodistrofia em uso da terapia anti-retroviral

Proteomic Profiling of Extracellular Vesicles Derived from Human Serum for the Discovery of Biomarkers in Avascular Necrosis

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