Efeitos da metformina na disfunção endotelial da circulação renal induzida pela hiperglicemia em coelhos não diabéticos

Gomes, Marília de Brito; Cailleaux, Solange; Tibiriçá, Eduardo

doi:10.1590/s0004-27302005000600013

Cited by 1 publication

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20,21 Some classes of medicaments have shown favorable effects on vascular reactivity like angiotensin converting enzyme inhibitor, statins, ascorbic acid, metformin, recently a phosphodiesterase V inhibitor, and sildenafil. 20,[22][23][24][25] Antoniades et al studied the relationship between blood lipoproteins (HDL and LDL), cholesterol, and triglycerides on vasodilatory response to reactive hyperemia in a cohort of young, low-risk adults. They found that elevated lipids in blood decrease vascular reactivity.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cilostazol and Pentoxifylline on Forearm Reactive Hyperemia Response, Lipid Profile, Oxidative Stress, and Inflammatory Markers in Patients With Intermittent Claudication

et al. 2008

View full text Add to dashboard Cite

Peripheral arterial disease may lead to lower limb claudication and increased risk of systemic vascular dysfunction. In this article, the authors have investigated the peripheral vascular dysfunction evaluating forearm blood flow using venous occlusion plethysmography, lipid profile, and C-reactive protein in 60 patients with moderate intermittent claudication treated during 20 weeks with placebo (n = 16), cilostazol (200 mg/d; n = 17), or pentoxifylline (1200 mg/d; n = 15) in a randomized double-blinded clinical trial, taking into account smoking. Forearm blood flow after reactive hyperemia response (FBF(h) ) or oral nitroglycerine spray to evaluate endothelial-dependent and endothelial-independent vasodilation, respectively, pain-free and maximal walking distance, levels of C-reactive protein, triglycerides, cholesterol, low-density lipoprotein, and high-density lipoprotein-cholesterol in plasma were determined. The results showed that there was an improvement in the high-density lipoprotein-cholesterol, pain-free and maximal walking distance, and FBF(h) independent of treatment in nonsmoking patients. Cilostazol increased high-density lipoprotein-cholesterol level, maximal walking distance, and FBF(h), whereas pentoxifylline reduced C-reactive protein level and increased maximal walking distance in total and nonsmoking groups. No treatment was effective in smokers.

show abstract