Correlação entre níveis de iodúria e TSH colhido em cordão umbilical de recém-nascidos do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, São Paulo

Abstract

Correlation Between Urinary Iodine Levels and TSH of Umbilical Cord fromNewborns of the University Hospital at the School of Medicine from Ribeirão Preto, São Paulo. The safest and most efficient way to diagnose congenital hypothyroidism (CH) is through screening programs using serum thyroid stimulating hormone (TSH). CH occurs in one in 1:2,300 -1:5,000 births but higher rates are found in iodine-deficient areas. Iodine was measured in the urine of 141 newborns (87 males and 54 females) from Ribeirão Preto to complement the screening program developed by the School of Medicine of Ribeirão Preto (FMRP-USP) and Federal University of São Paulo (UNIFESP). TSH values did not disclose any case of CH, although we have seen an elevated ratio (0.96%) of calls for retests. The iodine urinary levels ranged from 2.1 to 194µg/l (mean 58.3±36.2µg/l). No differences between the levels of urinary iodine and gender or gestational ages were observed. A negative correlation between urinary iodine and TSH of blood from umbilical cord was found (r= -0.20, p= 0.02).

Programa de triagem neonatal para hipotireoidismo congênito no nordeste do Brasil: critérios diagnósticos e resultados

“…Em Sergipe, um estado litorâneo do Nordeste do Brasil e com baixa altitude, a temperatura, o iodo ambiental e o iodo alimentar podem reduzir a concentração do TSH das crianças do PTN (47,52,54,55,80).…”

The Relationship Between Iodine Status and Thyroid Stimulating Hormone (TSH) and Free T4 (FT4) in Women of Childbearing Age in Wonogiri Regency

“…For other population groups, mean TSH values do not adequately discriminate between iodine-deficient and iodine-sufficient populations [30]. A negative relationship has been shown between UIC and TSH levels measured in the neonatal umbilical cord blood (r = -0.20, p = 0.02) [31]. For the reasons described in this finding, neonates thyroid has a low iodine content, and hence neonatal iodine turnover rate in the thyroid is much higher than in adults and children.…”

Avaliação ultrassonográfica da tireoide, determinação da iodúria e concentração de iodo em sal de cozinha utilizado por escolares de Ribeirão Preto, São Paulo, Brasil

“…Alves e cols. avaliaram, em 1988, a iodúria em recém-nascidos, concluindo que essa amostra populacional excretava iodo abaixo do recomendado pela OMS (20). Em 2003, a iodúria superior a 300 ug/L em 79,0% das amostras, 17,3% de bócio pela palpação e positividade de 20,2% nos títulos de anticorpos antitireoidianos em crianças de escolas municipais de diferentes níveis socioeconômicos foram considerados elevados para as faixas etárias examinadas (21).…”