Epidemiologia do câncer da tiróide no Brasil: apontando direções na política de saúde do país

Ward, Laura Sterian

doi:10.1590/s0004-27302005000400001

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Recent Brazilian data from the population-based cancer registry (RCBP) has demonstrated a significant increase in the incidence of thyroid cancer in the city of São Paulo from 2008 to 2012 (21). Although this seems to occur throughout the country, the results are more impressive in the southern, southeastern and northeastern regions, where diagnostic tools are more widely available (10,15,(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

“…Since overdiagnosis may represent an outsize problem for public health services, it is fundamental to evaluate this phenomenon especially in developing countries, where resources are scarce (22). However, no data on the quantity of procedures performed to investigate a thyroid nodule, treat and follow thyroid cancer patients, as well as its costs for the Brazilian public health system (SUS) are currently available.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid cancer burden and economic impact on the Brazilian public health system

Janovsky¹,

Bittencourt²,

Novais³

et al. 2018

Archives of Endocrinology and Metabolism

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Objective: Recent data indicates an increasing incidence of thyroid cancer not accompanied by a proportional increase in mortality, suggesting overdiagnosis, which may represent a big public health problem, particularly where resources are scarce. This article aims to describe and evaluate the procedures related to investigation of thyroid nodules and treatment and follow-up of thyroid cancer and the costs for the Brazilian public health system between 2008 and 2015. Materials and methods: Data on procedures related to investigation of thyroid nodules and treatment/follow-up of thyroid cancer between 2008 and 2015 in Brazil were collected from the Department of Informatics of the Brazilian Unified Health System (Datasus) website. Results: A statistically significant increase in the use of procedures related to thyroid nodules investigation and thyroid cancer treatment and follow-up was observed in Brazil, though a reduction was noted for procedures related to the treatment of more aggressive thyroid cancer, such as total thyroidectomy with neck dissection and higher radioiodine activities such as 200 and 250 milicuries (mCi). The procedures related to thyroid nodules investigation costs increased by 91% for thyroid ultrasound (p = 0.0003) and 128% in thyroid nodule biopsy (p < 0.001). Costs related to treatment and follow-up related-procedures increased by 120%. Conclusion: The increase in the incidence of thyroid cancer in Brazil is directly associated with an increased use of diagnostic tools for thyroid nodules, which leads to an upsurge in thyroid cancer treatment and followup-related procedures. These data suggest that substantial resources are being used for diagnosis, treatment and follow-up of a potentially indolent condition.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thyroid cancer burden and economic impact on the Brazilian public health system

Janovsky¹,

Bittencourt²,

Novais³

et al. 2018

Archives of Endocrinology and Metabolism

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“…Estudos retrospectivos são relativamente fáceis e econômicos de serem conduzidos, constituindo-se em uma fonte viável para o estabelecimento de hipóteses (FERRAZ et al, 2001;WARD, 2005 Indivíduos do gênero feminino receberam maior quantidade de diagnósticos do que os do gênero masculino, na proporção de 7,29:1. Este achado associa-se a maioria dos estudos publicados na literatura nacional e internacional.…”

Section: Resultsunclassified

Perfil epidemiológico do Câncer de Tireoide em subpopulação brasileira

Guedes¹,

Carvalhosa²

2023

Braz. J. Develop.

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Objetivo: Avaliar a prevalência do câncer de tireoide em subpopulação brasileira. Material e método: A amostra do estudo foi proveniente da revisão de prontuários clínicos de 1900 pacientes encaminhados ao Hospital do Câncer de Cuiabá, Mato Grosso, entre os anos de 2004 e 2011. Os seguintes dados foram coletados dos prontuários de cada paciente: idade, gênero, ano do diagnóstico e local de procedência. A análise estatística dos dados incluiu distribuição de frequência e teste de associação. A significância estatística para a associação entre as variáveis foi determinada pelo teste qui-quadrado. O nível de significância estabelecido foi de p < 0,05. Resultados: Observou-se elevada frequência de diagnósticos em indivíduos do gênero feminino (n = 1671; 87,9%) e com idade entre 51 - 60 anos (n = 541; 28,5%). Elevado número de diagnósticos foi estabelecido em 2008 (n = 388; 20,4%). A maioria dos pacientes diagnosticados era proveniente de cidades do interior do estado (n = 1186; 62,4%). Cuiabá foi o município com maior quantidade de casos (n =714; 37,6%). Conclusão: Verificou-se elevado número de casos de câncer de tireoide em indivíduos do gênero feminino, com idade superior a 51 anos, e provenientes de cidades do interior do estado do Mato Grosso.

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Fine‐needle aspiration biopsy of thyroid nodules as a possible source for molecular studies: Analysis of RNA obtained from routine cases

Mitteldorf

Sousa-Canavez

Massumoto

et al. 2008

Diagnostic Cytopathology

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Thyroid nodules are frequent in clinical practice and fine-needle aspiration biopsy (FNAB) is widely used for its evaluation, but approximately 20% of the cases are diagnosed as indeterminate for malignancy. Aspirates from thyroid nodules can be used for ancillary methods, but molecular techniques are not routinely applied to these specimens. Forty-six consecutive, routinely performed, FNAB of thyroid nodules were evaluated for the feasibility of applying RT-PCR method. RNA was extracted from 1 of 3 fresh residual samples and analyzed to determine its pureness, integrity, and concentration. Cellularity was adequate in all 46, except one, specimens analyzed, scored as 0, 1+, 2+, 3+, and 4+ in 1, 10, 14, 9, and 8 cases, respectively. Thirty-three nodules measured less than 1.5 cm. Cytological diagnosis was positive for malignancy in 3 cases, indeterminate for malignancy in 3, most probably benign follicular lesion in 7, negative for malignancy in 32, and suggestive of benign follicular lesion in 1. Good quality RNA was successfully isolated in 45/46 (97.8%) samples, with an average RNA concentration of 14 ng/microl and detection of B2M mRNA in 97.7% (44/45). There was no significant correlation between RNA concentration and nodule size or specimen cellularity. In conclusion, molecular analysis using individual, residual samples of thyroid nodules aspirates is feasible and could be employed for molecular preoperative studies in the future, adding elements for final cytological diagnosis of indeterminate cases, without altering the routine procedure.

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Epidemiologia do câncer da tiróide no Brasil: apontando direções na política de saúde do país

Cited by 5 publications

References 3 publications

Thyroid cancer burden and economic impact on the Brazilian public health system

Thyroid cancer burden and economic impact on the Brazilian public health system

Perfil epidemiológico do Câncer de Tireoide em subpopulação brasileira

Fine‐needle aspiration biopsy of thyroid nodules as a possible source for molecular studies: Analysis of RNA obtained from routine cases

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