Insuficiência androgênica na mulher e potenciais riscos da reposição terapêutica

Abstract

Women in their fourth decade and older experience a decrease in androgen serum levels. This may lead to the clinical syndrome of female androgen insufficiency expressed by insidious tiredness, diminished sense of well-being and libido, alterations in body composition and bone loss. If there is a past history of bilateral oophorectomy, hypopituitarism, androgen adrenal suppression and/or free testosterone serum levels are low, it is probable that these signs and symptoms could be relieved by a discerning androgen administration, which has been largely accepted. When current recommended doses are used, it appears that the benefits regarding bone mass, sexuality and well-being may be achieved without important signs of masculinizing. Nonetheless, it is necessary to conduct well-controlled, long-term studies, in order to validate the hypothesis that therapeutic administration of androgens to women does not lead to an increased incidence of breast cancer or metabolic complications.

Efeitos dos esteroides anabólicos androgênicos sobre o útero e parâmetros reprodutivos de ratas adultas

“…Na tentativa de restabelecimento da libido e no tratamento da osteoporose pós-menopausa são utilizados, respectivamente, ésteres mistos injetáveis de testosterona e decanoato de nandrolona 23 . A combinação desses esteroides em nosso estudo, com animais saudáveis, levou à supressão do ciclo com persistência da fase de diestro.…”

Hormone replacement therapy in menopause as a risk factor for developing breast cancer

“…19 One of the topics discussed was classified with the theme of other in selected works, addressed precisely these hormones combined and as alternative solution to the possible risks of HRT.…”

Hormone replacement therapy in menopause as a risk factor for developing breast cancer

“…However according to experts, there is a need for a greater number of trials to assess the impact of combined replacement of androgens and estrogens on breast tissue. 19 One of the topics discussed was classified with the theme of other in selected works, addressed precisely these hormones combined and as alternative solution to the possible risks of HRT.…”