Efeito do hipotireoidismo no tumor de Ehrlich sólido em camundongos fêmeas castradas e não castradas

Abstract

The effect of hypothyroidism on the solid form of the Ehrlich tumor in intact or castrated adult female mice was studied. Hypothyroidism was induced by treatment with propylthiouracil (PTU). Forty mice were divided into four groups: castrated hypothyroid, intact hypothyroid, castrated euthyroid, and intact euthyroid. The mice were inoculated with suspension cells into the left footpad. The tumor growth curve was determined by measuring the inoculated footpad during 12 days. At the end of the experimental period the mice were sacrificed. Hypothyroidism was associated with a reduction in size of the tumor only in the castrated animals. Although the neoplastic growth was lower, mean nuclear diameter, number of nucleolar organizer regions (NORs), and area of mitosis were higher. In conclusion, hypothyroidism resulted in a delayed growth of the tumor, but it did not affect the malignant features of the neoplastic cells. In addition, the isolated effect of castration caused only mild alterations, whereas hypothyroidism associated with castration resulted in a more prominent delay in the growth rate of the Ehrlich tumor.

Efeito do miriadenolídeo isolado de Alomia myriadenia (Asteraceae) sobre o tumor de Erlich ascítico no camundongo

“…Vários autores utilizam a determinação das AgNORs como uma estratégia indicadora da proliferação celular (Silva et al, 2004;Silva et al, 2006;Romão-Correa et al, 2005 (Ghosh et al, 1999). A mielossupressão é a principal e também a mais freqüente complicação na quimioterapia do câncer (Mazumder et al, 2005).…”

Effect of Thyroxine and Propylthiouracil in Ehrlich Ascitic Tumor Cells

“…In order to assess the effect of thyroid dysfunctions on breast cancer prognosis, Ehrlich tumor has also been proposed as an experimental model. Studies have shown that hypothyroidism slows tumor growth even without changing malignity cell characteristics (Silva et al, 2004) and that hyperthyroidism promotes this growth . But it is not clear whether this effect is caused by thyroid dysfunction or by direct action of drugs used to experimentally induce hypo and hyperthyroidism.…”

Influência do hipotireoidismo na progressão do melanoma experimental

“…(MISHIKIN et al, 1979;DAGHER, 1979;OREN et al, 1996;SILVA et al, 2004) Cooper et al (1983 Seguindo relatos anteriores, considerou-se um período de 15 dias para indução do estado hipotireoidiano antes de qualquer inoculação de células tumorais.…”