Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster

Franchi, Leonardo Pereira; Guimarães, Nilza Nascimento; Andrade, L.; Andrade, Heloı́sa Helena Rodrigues de; Lehmann, Maurı́cio; Dihl, Rafael Rodrigues; Cunha, Kênya Silva

doi:10.1590/s0001-37652013000200008

Cited by 12 publications

(8 citation statements)

References 47 publications

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“…Morinda citrifolia (commonly known as Noni fruit) is often used in the folk medicine of the Indian. The anticarcinogenic and antimutagenic effects of Noni juice were proved in Drosophila [69], as well as in humans [70]. However, in our study we did not confirm the reports of high phenolic content in Noni [69,71].…”

Section: Discussioncontrasting

confidence: 98%

Berry fruit juices protect lymphocytes against DNA damage and ROS formation induced with heterocyclic aromatic amine PhIP

Kalemba-Drożdż

Cierniak

Cichoń

2020

JBR

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BACKGROUND: Heterocyclic aromatic amines are formed during thermal processing of meat and are known to be mutagenic and carcinogenic factors, while the consumption of fruit and vegetables decreases the risk of cancer. OBJECTIVE: The aim of the study was to investigate if berry fruit juices, a rich source of antioxidants (polyphenols, flavonoids, anthocyanins, ascorbate), may protect DNA from damages induced by the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine (PhIP). METHODS: Lymphocytes isolated from healthy volunteers were treated with 25-100 M PhIP in the presence or absence of pressed berry juice (0.1%) from: bilberry (Vaccinium myrtillus), chokeberry (Aronia melanocarpa), cranberry (Vaccinium oxycoccos), raspberry (Rubus idaeus), rosehips (Rosa rugosa), sea-buckthorn (Hippophae rhamnoides), Noni (Morinda citrifolia) and Goji (Lycium barbarum). Antioxidant power, polyphenols, flavonoids, anthocyanins and ascorbate concentration in juices were determined. DNA damage was measured using comet assay. RESULTS: Berry juices were not genotoxic and caused an overall significant decrease in oxidative stress and DNA damage induced by PhIP. The antioxidant properties depend on concentration of polyphenols in juice. CONCLUSIONS: Northern Hemisphere berries bear the negative effects of food mutagens. Berries as natural source of polyphenols should be recommended in daily diet for maintaining health.

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Section: Discussioncontrasting

confidence: 98%

Berry fruit juices protect lymphocytes against DNA damage and ROS formation induced with heterocyclic aromatic amine PhIP

Kalemba-Drożdż

Cierniak

Cichoń

2020

JBR

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“…The antimutagenic and anti‐recombinogenic action of TNJ® in D. melanogaster somatic cells has been verified (Franchi et al , ).…”

Section: Antimutagenic Activitymentioning

confidence: 96%

“…Noni fruit juice, with or without seeds, is capable of modulating cell‐mediated immune response and antioxidant enzyme activity in vitro (Pratap et al , ). In a Drosophila melanogaster somatic cell model, the protective effects of TNJ® depended on its concentration, indicating a dose–response correlation, which can be attributed to either a powerful antioxidant action or the ability to capture free radicals (Franchi et al , ).…”

Section: Antioxidant Activitymentioning

confidence: 99%

One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia

Torres

Magalhães

Mondêgo-Oliveira

et al. 2017

Phytotherapy Research

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Morinda citrifolia, also known as noni, is commonly used in popular medicine in Brazil. Many parts of the noni tree are utilized in such practices, including the roots, leaves and seeds. Through a search of online databases, the present article reviews 92 research studies on the biological actions of M. citrifolia. The paper will discuss the therapeutic effects of noni and its compounds in a variety of forms of presentation, focusing on studies that support its traditional use. A large and diverse number of properties were identified, which were divided into immunostimulatory, antitumor, antidiabetic, anti-obesity, antibacterial and anti-septic, antifungal, antiviral, leishmanicidal, antiinflammatory, antinociceptive and analgesic, antioxidant, neuroprotective, wound healing, antiallergic, antiangiogenic, antiemetic and anti-nausea, anti-gastric ulcer and oesophagitis, anthelmintic, antimutagenic, antipsychotic, anxiolytic, photoprotective, anti-wrinkle and periodontal tissue regeneration activities. While it was concluded that although M. citrifolia is widely and successfully used for the treatment or prevention of various diseases, it should be consumed carefully, and only after exhaustive studies into its chemical constituents and mechanisms of action, both in in vitro and in vivo models, as well as clinical trials. Copyright © 2017 John Wiley & Sons, Ltd.

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“…On the single hand, the wing-spot test is a method depending on the loss of heterozygosity production that might take place through several ways, such as a wide range of mutational events as well as mitotic recombination. This outstanding technique detects concurrently mutational and mitotic recombination, being able to enumerate the recombinogenic activity of a substance in a genotoxicity screening [31]. In the same vein, the comet experiment is an outstanding technique broadly utilized for in vivo mutagenicity screening, since it can employ to a varied variety of cells, it can detect lesser amounts of DNA impairment and can identify various kinds of DNA damage [32].…”

Section: Discussionmentioning

confidence: 99%

Genotoxic and Carcinogenic Studies of Norgestrel in Drosophila Melanogaster

Abou-Eisha

El-Din

2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to investigate, for the first time, the possible in vivo genotoxic and carcinogenic activity associated with exposure to norgestrel (NGT) drug through employing the very recently established and adjusted genotoxic and tumorigenic methods in Drosophila melanogaster.Methods: Two in vivo genotoxic test systems were used; one detects the somatic mutation and recombination effects (somatic mutation and recombination test [SMART] wing-spot test) and the other detects the primary DNA damage (the comet test) in the body cells of D. melanogaster. On the other hand, the warts (wts)-based SMART assay is a vital genetic examination in Drosophila used to identify and characterize cancer potential of compounds.Results: Four experimental doses of NGT were used (ranging from 0.24 μM to 16 μM). NGT was found to be non-genotoxic at all tested concentrations even at the highest dose level 16 μM and failed to increase the frequency of tumors in the somatic cells of D. melanogaster.Conclusion: Our results strengthen the hypothesis that steroidal drugs might act through a non-genotoxic carcinogen mechanism where the carcinogenic properties occur by direct stimulation of cellular proliferation through a steroid receptor-mediated mechanism. In addition, the results obtained in this research work may contribute to highlighting the importance of NGT as a potent neuroprotective antioxidant drug.

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Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster

Cited by 12 publications

References 47 publications

Berry fruit juices protect lymphocytes against DNA damage and ROS formation induced with heterocyclic aromatic amine PhIP

Berry fruit juices protect lymphocytes against DNA damage and ROS formation induced with heterocyclic aromatic amine PhIP

One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia

Genotoxic and Carcinogenic Studies of Norgestrel in Drosophila Melanogaster

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