Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark

Abstract

Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also showed marked antinociceptive effect in acetic acid-induced writhing test and in the second phase of formalin test in mice. These findings evidence the anti-inflammatory potential of Bowdichia virgilioides bark and supports its traditional use in inflammatory conditions.

Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice

“…The extract of Bowdichia virgilioides showed antimicrobial activity (J.G.R. Feitosa et al, unpublished data, Almeida et al 2006), analgesic and antiinflammatory effects , Thomazzi et al 2010, Barros et al 2010. So, if any plant material presents antimicrobial, analgesic and antiinflammatory activities together, it can be supposed that this material also may help to promote wound healing and contribute skin regeneration.…”

“…The stem bark preparations of the B. virgilioides are reported to have antimalarial (Deharo et al 2001), analgesic and anti-inflammatory activities , Thomazzi et al 2010, Barros et al 2010. The stem bark contains several chemical substances such as lupeol, lupeol acetate, sitosterol and stigmasterol (Melo et al 2001).…”

Antioxidant properties of species from the Brazilian cerrado by different assays

“…Anti-inflammatory and antinoceptive potential (Thomazzia et al, 2010;Silva et al, 2010;Barros et al, 2010) Cardiotonic, sedative and hypoglycemic activities (Aragão et al, 2010;Consolini et al, 2006;) Rheumatism and renal colic (Rodrigues & Carvalho, 2001) Diarrhoea, dysentery, intestinal colic, cystitis, antiviral activity and inhibition of 5-lipoxygenase (Cecílio et al, 2012;Lorenzi & Matos, 2002;Braga et al, 2000;Panizza, 1997) Antidiarrheal, gastro-protective and cicatrising activities (Orsi et al, 2012) Jacaranda species are used for blenorrhagy, skin ulcers, anti-syphilis and anti-gonorrhoea, and anti-inflammatory remedies (Gachet & Schühly, 2009) Struthanthus species are used in parasitosis and skin disorders (Martinez & Barboza, 2010) Wound-healing, anti-inflammatory, anti-ulcerogenic, anti-tyrosinase and Molluscicidal activities (Lopes et. al, 2005;Rebecca et al, 2003;Baurin et al, 2002;Bezerra et al, 2002) Antimalarial, anticancer, hypoglycaemic (Masaba, 2000;Izevbigie et al, 2008) FeCl3 (0.1%).…”

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

“…Based on a comprehensive analysis of these results, it was hypothesized that the drug may have a significant anti-exudation effect. Among the numerous animal models, the mouse model of acetic acid-induced peritonitis is commonly used to estimate anti-exudation effects of drugs (12), and is characterized by increased vascular permeability, fluid exudation, leukocyte migration and inflammatory cytokine release to the abdominal cavity (24). In this model, the degree of Table I.…”

“…In order to investigate the anti-exudation activity of sodium ferulate and oxymatrine combination, the mice were injected with Evans blue and peritonitis was induced with acetic acid according to a previously described method (12). Mice used in the experiment were randomly divided into a normal control group (saline), a model group (saline and acetic acid), 5 Each group contained 10 animals.…”