Cytogenotoxicity of Cymbopogon citratus (DC) Stapf (lemon grass) aqueous extracts in vegetal test systems

Sousa, Saulo Marçal de; Silva, Pâmela S.; Viccini, Lyderson Facio

doi:10.1590/s0001-37652010000200006

Cited by 36 publications

(17 citation statements)

References 17 publications

(10 reference statements)

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“…Native from India and Southeast Asia, it is distributed in numerous tropical countries, including Brazil (DUARTE & ZANETI, 2004;SOUSA et al, 2010). There are several popular uses for this plant, including treatment for stomach pains, diarrhea (TANGPU & YADAV, 2006), also having several pharmacological activities such as anti-amoebic and as antifungal (SHAH et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and insecticidal activity of Cymbopogon citratus essential oil from Cuba and Brazil against housefly

Pinto

Sánchez²,

Santos

et al. 2015

Rev. Bras. Parasitol. Vet.

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Essential oil of Cymbopogon citratus collected from Brazil and Cuba was tested to a chemical characterization and then was tested on the post-embryonic development of Musca domestica. The chemical composition analysis by GC-MS of the oils from Brazil/Cuba allowed the identification of 13 and 12 major constituents respectively; nine of them common to both. In the both oils, the main components were the isomers geranial and neral, which together form the compound citral. This corresponds to a total of 97.92%/Brazil and 97.69%/Cuba of the compounds identified. The monoterpene myrcene, observed only in the sample of Cuba, presented a large relative abundance (6.52%). The essential oil of C. citratus (Brazil/Cuba) was dissolved in DMSO and tested at concentrations of 5, 10, 25, 50, 75 and 100% and citral was prepared by mixing 16.8 mg with 960 µL DMSO. Both essential oils and monoterpene citral were applied topically to newly-hatched larvae (1µL/larva). The results showed a lethal concentration (LC50) of 4.25 and 3.24% for the Brazilian and Cuban essential oils, respectively. Mortalities of larval and newly-hatched larvae to adult periods were dose-dependent for the two both oils as for monoterpene citral, reaching 90%. Both essential oils and citral caused morphological changes in adult specimens.Keywords: Vector control, essential oil, house-fly, lemongrass, Cymbopogon citratus. ResumoO óleo essencial de Cymbopogon citratus, coletado no Brasil e em Cuba, foi caracterizado quimicamente e testado no desenvolvimento pós-embrionário de Musca domestica. A análise da composição química dos óleos essenciais (Brasil/Cuba), por Cromatografia Gasosa acoplada ao espectrômetro de massa (GC-EM), permitiu a identificação de 13 e 12 componentes principais, respectivamente; nove deles comuns aos dois. Em ambos os óleos, os principais componentes foram os isômeros geranial e neral, que, juntos, formam o composto citral. Esse corresponde a um total de 97,92%/Brasil e 97,69%/Cuba dos compostos identificados. O monoterpeno mirceno, observado na amostra cubana, apresentou grande abundância relativa (6,52%). O óleo de C. citratus (Brasil/Cuba) foi dissolvido em DMSO, obtendo-se as concentrações de 5, 10, 25, 75 e 100%; e o citral (16,8 mg) foi misturando com 960mL de DMSO. Tanto o óleo essencial como o monoterpeno citral foram aplicados topicamente nas neolarvas (1µL/larva). Os resultados mostraram uma concentração letal (CL50)

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Section: Introductionmentioning

confidence: 99%

Chemical composition and insecticidal activity of Cymbopogon citratus essential oil from Cuba and Brazil against housefly

Pinto

Sánchez²,

Santos

et al. 2015

Rev. Bras. Parasitol. Vet.

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“…At a concentration of 50 mg dry plant weight, Cymbopogon nardus (1), commonly used as an insect repellent, showed the strongest inhibition, completely inhibiting both the hypocotyl and radicle growth of the lettuce. A few studies have reported that Cymbopogon species and their major constituents act as allelopathic species in inhibiting the germination and seedling growth of test plants (Sousa et al, 2010;Alves et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Screening the Allelopathic Activity of 14 Medicinal Plants from Northern Thailand

Suwitchayanon

Kunasakdakul

Kato‐Noguchi

2017

Environmental Control in Biology

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Fourteen medicinal plants from northern Thailand, which dominate and form large colonies, were dried, powdered, and evaluated for growth inhibitory activity using a modified sandwich method. All the plants showed inhibitory activities on the growth of lettuce seedlings: Cymbopogon nardus had the strongest activity, completely inhibiting the growth of the lettuce hypocotyls and radicles; Piper retrofractum completely inhibited the hypocotyl growth and 93.5% of the radicle growth; and the remaining plants inhibited hypocotyl and radicle growth by 30.9 57.4% and 44.1 75.3%, respectively. Inhibitory active compounds may have been released from the plants into the sandwich method medium and inhibited the growth of the lettuce seedlings. The present results suggest that C. nardus and P. retrofractum are possible candidates for developing alternative natural herbicides in sustainable agriculture because of their strong inhibitory activity.

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“…The biocide activity in the more concentrated dose (Yar 4 = 30 mg/mL) and the little development and germination of lettuce in higher concentrations of yarrow extracts are very interesting for a future utilization in the biocontrol of weed and pest development, being possible its utilization as bioherbicide. Innumerous medicinal species have demonstrated this potentiality (Negrelle & Gomes, 2007;Lubini et al, 2008;Sousa et al, 2009;2010).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and genotoxic activity of Achillea millefolium L., Asteraceae, aqueous extracts

Sousa¹,

Viccini²

2011

Rev. bras. farmacogn.

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Abstract:The yarrow, Achillea millefoilum L. is an important species of Asteraceae family with common utilization in folk medicine of many countries. The aim of this study was to investigate the cytotoxic and genotoxic effects of aqueous extracts from yarrow leaves on Lactuca sativa (lettuce) root tip meristem cells by cytogenetic studies, since studies of this nature do not exist for the yarrow extracts. For this, lettuce seeds were treated for 72 h with different concentrations of yarrow aqueous extracts (5, 10, 20 and 30 mg/mL). The percentage of germination, root development and cellular behavior were analyzed and the results showed that the highest concentration of aqueous extracts reduced the mitotic index (MI), the seed germination and the root development of L. sativa. More yet, the extracts also induced chromosome aberrations (CA) and cellular death in the roots cells of L. sativa indicating precaution in the therapeutic use of A. millefolium and reinforcing the utilization of L. sativa in the screening of cytogenotoxic substances once that this species showed a good sensibility to the extract application.

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Cytogenotoxicity of Cymbopogon citratus (DC) Stapf (lemon grass) aqueous extracts in vegetal test systems

Cited by 36 publications

References 17 publications

Chemical composition and insecticidal activity of Cymbopogon citratus essential oil from Cuba and Brazil against housefly

Chemical composition and insecticidal activity of Cymbopogon citratus essential oil from Cuba and Brazil against housefly

Screening the Allelopathic Activity of 14 Medicinal Plants from Northern Thailand

Cytotoxic and genotoxic activity of Achillea millefolium L., Asteraceae, aqueous extracts

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