Preparation and characterization of hydroxyapatite-coated iron oxide particles by spray-drying technique

Abstract

Magnetic particles of iron oxide have been increasingly used in medical diagnosis by magnetic resonance imaging and in cancer therapies involving targeted drug delivery and magnetic hyperthermia. In this study we report the preparation and characterization of iron oxide particles coated with bioceramic hydroxyapatite by spray-drying. The iron oxide magnetic particles (IOMP) were coated with hydroxyapatite (HAp) by spray-drying using two IOMP/HAp ratios (0.7 and 3.2). The magnetic particles were characterized by way of scanning electronic microscopy, energy dispersive X-ray, X-ray diffraction, Fourier transformed infrared spectroscopy, flame atomic absorption spectrometry, vibrating sample magnetometry and particle size distribution (laser diffraction). The surface morphology of the coated samples is different from that of the iron oxide due to formation of hydroxyapatite coating. From an EDX analysis, it was verified that the surface of the coated magnetic particles is composed only of HAp, while the interior contains iron oxide and a few layers of HAp as expected. The results showed that spray-drying technique is an efficient and relatively inexpensive method for forming spherical particles with a core/shell structure.

Synthesis and Characterization of Fe-doped Hydroxyapatite

“…For instance, fluoride-substituted hydroxyapatite has better thermal and chemical stabilities than hydroxyapatite (Eslami H. et al 2008). However, vertebrate bone and tooth minerals are considered to contain HA structure with various substitution of Na , Cl¯, F¯ ions (Wang J. et al 2008, Donadel K. et al 2009). …”

“…Iron is one of the trace elements in bone and teeth (Wang J. et al 2008) and it is a vital element in the circulatory system, essential for the functioning of numerous proteins in cells (Donadel K. et al 2009). The presence of iron in HA lattice greatly influences its solubility and crystallinity (Wang J. et al 2008).…”

Stable dispersions of poly(ethylene glycol) methyl ether–magnetite complexes in water

“…Magnetite ferrofluids have recently attracted marked attention for uses in many biomedical applications such as hyperthermia [1][2][3][4], magnetic resonance imaging (MRI) [5][6][7][8][9][10][11][12] and magnetic drug targeting [13][14][15][16][17]. 3 ) in merely organic compounds containing hydroxyl groups, such as benzyl alcohol [18], tetraethylene glycol and triethylene glycol [19].…”

“…3 ) in merely organic compounds containing hydroxyl groups, such as benzyl alcohol [18], tetraethylene glycol and triethylene glycol [19]. These compounds functioned as both reaction solvents and reducing agents because they have high boiling points, high polarities and OH reactive functional groups.…”

Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

“…The synthesized MHAp nanoparticles were spray-dried and atomized using the Büchi B-191 dryer with an inlet temperature of 170 and 90°C and a pressure of 5 bar gauge. 75 Xu et al reported the use of MHAp nanoworms for diagnosing acute hepatic injury by MRI. They briefly discussed four steps for synthesizing MHAp nanoworms.…”