Identification of the antimicrobial substances produced by Solanum palinacanthum (Solanaceae)

Pereira, Aline Carvalho; Oliveira, Denilson F.; Silva, Geraldo Humberto; Figueiredo, Henrique César Pereira; Cavalheiro, Alberto José; Carvalho, Daniel Diego Costa; Souza, L. P.; Chalfoun, Sara Maria

doi:10.1590/s0001-37652008000300004

Cited by 23 publications

(10 citation statements)

References 26 publications

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“…3,5‐dicaffeoylquinic acid ( 4 ) was inhibiting all microorganisms tested, while 1,3‐dicaffeoylquinic acid ( 5 ) produced a wider inhibition zone in the yeast than against bacteria, especially E. faecalis and P. aeruginosa . The results obtained with phenolic acids agree with previous reports on the antimicrobial activity by these compounds .…”

Section: Resultssupporting

confidence: 91%

Bioactive Secondary Metabolites from Schizogyne sericea (Asteraceae) Endemic to Canary Islands

Venditti¹,

Bianco²,

Muscolo³

et al. 2016

Chemistry & Biodiversity

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Schizogyne sericea (Asteraceae) is a halophytic shrub endemic to the Canary Islands and traditionally employed as analgesic, astringent, anti-inflammatory, and vulnerary. A comprehensive phytochemical investigation was conducted on the flowering aerial parts by analyzing both essential oil constituents and polar compounds. The essential oil was dominated by p-cymene, with the noteworthy occurrence of β-pinene and thymol esters. From the EtOH extract, eight compounds were isolated and structurally elucidated. Essential oil, polar fractions, and isolates (2), (4), and (5) were separately in vitro assayed for antiproliferative activity on human tumor cell lines (A375, MDA-MB 231, and HCT116) by MTT assay, for antioxidant potential by DPPH, ABTS, and FRAP assays, and for antimicrobial activity by the agar disk diffusion method. Results revealed that essential oil and compounds 1 and 2 exert a strong inhibition on tumor cells, and in some cases, higher than that of cisplatin. Fractions containing thymol derivatives (1 and 2) and caffeoylquinic acid derivatives 4 and 5 displayed antioxidant activity comparable to that of Trolox, making S. sericea extract an interesting natural product with potential applications as preservative or in the treatment of diseases in which oxidative stress plays an important role.

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Section: Resultssupporting

confidence: 91%

Bioactive Secondary Metabolites from Schizogyne sericea (Asteraceae) Endemic to Canary Islands

Venditti¹,

Bianco²,

Muscolo³

et al. 2016

Chemistry & Biodiversity

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“…Morin and rutin alone had no activity against MRSA but in combination showed antibacterial activity against said bacteria. In similar studies flavonoids combinations and their metallo-combinations show activity against various microbes [26,27]. Morin alone has been found to be active against Salmonella enteritidis with MIC of 150 μg/ml and B. cereus with MIC of 300 μg/ml.…”

Section: Discussionmentioning

confidence: 94%

Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus

Amin

Khurram

Khattak

et al. 2015

BMC Complement Altern Med

153

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BackgroundTo determine the effect of flavonoids in conjunction with antibiotics in methicillin resistant Staphylococcus aureus (MRSA) a study was designed. The flavonoids included Rutin, Morin, Qurecetin while antibiotics included ampicillin, amoxicillin, cefixime, ceftriaxone, vancomycin, methicillin, cephradine, erythromycin, imipenem, sulphamethoxazole/trimethoprim, ciprofloxacin and levolfloxacin. Test antibiotics were mostly found resistant with only Imipenem and Erythromycin found to be sensitive against 100 MRSA clinical isolates and S. aureus (ATCC 43300). The flavonoids were tested alone and also in different combinations with selected antibiotics.MethodsAntibiotics and flavonoids sensitivity assays were carried using disk diffusion method. The combinations found to be effective were sifted through MIC assays by broth macro dilution method. Exact MICs were determined using an incremental increase approach. Fractional inhibitory concentration indices (FICI) were determined to evaluate relationship between antibiotics and flavonoids is synergistic or additive. Potassium release was measured to determine the effect of antibiotic-flavonoids combinations on the cytoplasmic membrane of test bacteria.ResultsAntibiotic and flavonoids screening assays indicated activity of flavanoids against test bacteria. The inhibitory zones increased when test flavonoids were combined with antibiotics facing resistance. MICs of test antibiotics and flavonoids reduced when they were combined. Quercetin was the most effective flavonoid (MIC 260 μg/ml) while morin + rutin + quercetin combination proved most efficient with MIC of 280 + 280 + 140 μg/ml. Quercetin + morin + rutin with amoxicillin, ampicillin, cephradine, ceftriaxone, imipenem, and methicillin showed synergism, while additive relationship was indicated between morin + rutin and amoxicillin, cephradine, ceftriaxone, imipenem, and methicillin. Quercetin alone had an additive effect with ampicillin, cephradine, ceftriaxone, imipenem, and methicillin. Potassium leakage was highest for morin + rutin + quercetin that improved further in combination with imipenem. Morin and rutin alone had no activity but in combination showed activity against test bacteria.ConclusionsThe flavonoids when used in combination with antibiotics were found to increase each other activity against test bacteria. The relationship between the flavonoids and antibiotics in most of the cases was additive. However in a few cases synergism was also observed. Flavonoids alone or in combinations also damaged bacterial cell membrane.

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“…Against a range of fungi of the genus Aspergillus, Weidenbörner et al (1990) reported little activity for quercetin and naringenin. Pereira et al (2008) observed in A. ochraceus that the MIC value for rutin was 35 mg/l.…”

Section: Discussionmentioning

confidence: 98%

Inhibition of growth and ochratoxin A biosynthesis in Aspergillus carbonarius by flavonoid and nonflavonoid compounds

Romero

Arena

Nadra³

et al. 2009

Mycotox Res

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The effect of naturally occurring phenolic compounds on Aspergillus carbonarius growth and ochratoxin A (OTA) production was studied. Caffeic acid and the flavonoids, rutin and quercetin, were added to Czapek Yeast Extract agar at concentrations ranging between 50 and 500 mg/l. All phenolic compounds had a significant influence on growth rate and lag phase of A. carbonarius at 250 mg/l. The growth was completely inhibited with 500 mg/l. In comparison with the control, a significant decrease in OTA production was observed with all phenolic compounds. In general, effect on growth was less evident than effect on toxin production. An inhibitory effect on growth and OTA production, as concentration was increased was observed in all cases. The response of A. carbonarius to the flavonoids, rutin and quercetin, was similar. The inhibitory effect of these natural phenolic compounds on fungal growth and OTA production could be an alternative to the use of chemical fungicides.

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Identification of the antimicrobial substances produced by Solanum palinacanthum (Solanaceae)

Cited by 23 publications

References 26 publications

Bioactive Secondary Metabolites from Schizogyne sericea (Asteraceae) Endemic to Canary Islands

Bioactive Secondary Metabolites from Schizogyne sericea (Asteraceae) Endemic to Canary Islands

Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus

Inhibition of growth and ochratoxin A biosynthesis in Aspergillus carbonarius by flavonoid and nonflavonoid compounds

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