Protective effect of L-carnitine on myocardial injury in rats with heatstroke

Wang, Xisong; Liu, Yingyu; Zhang, Chunlai; Song, Qing

doi:10.1590/acb351206

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…Moreover, in acute conditions, such as in myocardial infarction, LC could mitigate abnormal oxidative stress condition and enhance cardiomyocytes survival. Animal studies and preliminary clinical studies seem to confirm this hypothesis [195][196][197][198]. It is important to note that these first trials suggest that LC improves antioxidative cellular defense, in particular the NRF2 pathway [198].…”

Section: From Caloric Restriction To Cr-related Nutrients: L-carnitinementioning

confidence: 78%

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Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Senesi

Ferrulli

Luzi

et al. 2021

IJMS

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Type 2 diabetes (T2DM) and cardiovascular disease (CVD) are closely associated and represent a key public health problem worldwide. An excess of adipose tissue, NAFLD, and gut dysbiosis establish a vicious circle that leads to chronic inflammation and oxidative stress. Caloric restriction (CR) is the most promising nutritional approach capable of improving cardiometabolic health. However, adherence to CR represents a barrier to patients and is the primary cause of therapeutic failure. To overcome this problem, many different nutraceutical strategies have been designed. Based on several data that have shown that CR action is mediated by AMPK/SIRT1 activation, several nutraceutical compounds capable of activating AMPK/SIRT1 signaling have been identified. In this review, we summarize recent data on the possible role of berberine, resveratrol, quercetin, and L-carnitine as CR-related nutrients. Additionally, we discuss the limitations related to the use of these nutrients in the management of T2DM and CVD.

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Section: From Caloric Restriction To Cr-related Nutrients: L-carnitinementioning

confidence: 78%

“…Heart: ↑ anti-oxidative factors ↓ inflammatory response ↓ oxidative stress ↓ cardiomyocytes apoptosis Wang et al [195] In vitro and in vivo (rats with I/R injury)…”

Section: Type Of Studies Tissue Molecular Mechanisms Effects Referencesmentioning

confidence: 99%

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Senesi

Ferrulli

Luzi

et al. 2021

IJMS

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“…Since there are so little studies on the effects of LC tendon recovery, we aimed to research the effects of LC on an Achilles tendon injury model. It has been reported that the most effective dose of LC is 100 mg/kg/day (19)(20)(21). For this reason, LC was preferred to administer once daily at dose of 100 mg/kg intraperitoneally in our study.…”

Section: Discussionmentioning

confidence: 97%

The Effect of L-Carnitine on Experimental Achilles Tendon Injury

Kasar,

Demirci,

Hünler

et al. 2023

Muscle Ligaments and Tendons J

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Background. L-carnitine (LC), which has anti-inflammatory and antioxidant effect, is especially consumed by sportmans to increase muscle mass recently. Therefore, the functional, histopathological effects of LC on experimental Achilles tendon injury were investigated in this study. Methods. Forty male Wistar Albino rats were randomly divided into four groups (n = 10). A tendon injury model was created by clamping the left Achilles tendon of all rats except the control group. Tendon Injury Group (TIG) and the Control group did not receive LC treatment. LC (100 mg/kg/day, intraperitoneally) was started to administer one week before the injury model in pre-LC group and the same day of injury in post-LC group following the establishment of model for four weeks. After the tendon injury and at the end of the experiment, rats in all groups were subjected to a Gait test (GT) twice. On the 30 th day of injury, the rats were sacrificed, and left Achilles tendons were dissected for histopathological analysis. Results. Initial GT data were significantly different between the control and other groups (p < 0.001). The final GT data were significantly different only between the Control and TIG (p = 0.002). Histopathological examination revealed that neovascularization, fibroblastic activity, and collagen fibril sequencing parameters were found to be significantly different amongst the TIG and pre-LC group, and post-LC group (p < 0.05). Conclusions. LC contributes to the tendon healing by histopathologically and functionally.

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“…This amino acid derivative is essential in energy metabolism. Carnitine has attracted interest in ICU patients because of the high risk of secondary deficiency in critical illness and its suggested anti-inflammatory and antioxidant properties [1 ▪▪ ,71]. CRRT efficiently removes carnitine, and deficiency has been reported in 70.6% of ICU patients with CRRT [8 ▪ ].…”

Section: Carnitinementioning

confidence: 99%

An update on essential micronutrients in critical illness

Berger

2023

Current Opinion in Critical Care

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Purpose of review Numerous micronutrients are involved in antioxidant and immune defence, while their blood concentrations are frequently low in critically ill patients: this has fuelled many supplementation trials. Numerous observational, randomized studies have been published, which are presented herein. Recent findings Micronutrient concentrations must be analysed considering the context of the inflammatory response in critical illness. Low levels do not always indicate a deficiency without objective micronutrients losses with biological fluids. Nevertheless, higher needs and deficiencies are frequent for some micronutrients, such as thiamine, vitamins C and D, selenium, zinc and iron, and have been acknowledged with identifying patients at risk, such as those requiring continuous renal replacement therapy (CRRT). The most important trials and progress in understanding have occurred with vitamin D (25(OH)D), iron and carnitine. Vitamin D blood levels less than 12 ng/ml are associated with poor clinical outcomes: supplementation in deficient ICU patients generates favourable metabolic changes and decreases mortality. Single high-dose 25(OH)D should not be delivered anymore, as boluses induce a negative feedback mechanism causing inhibition of this vitamin. Iron-deficient anaemia is frequent and can be treated safely with high-dose intravenous iron under the guidance of hepcidin to confirm deficiency diagnosis. Summary The needs in critical illness are higher than those of healthy individuals and must be covered to support immunity. Monitoring selected micronutrients is justified in patients requiring more prolonged ICU therapy. Actual results point towards combinations of essential micronutrients at doses below upper tolerable levels. Finally, the time of high-dose micronutrient monotherapy is probably over.

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Protective effect of L-carnitine on myocardial injury in rats with heatstroke

Cited by 8 publications

References 16 publications

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

The Effect of L-Carnitine on Experimental Achilles Tendon Injury

An update on essential micronutrients in critical illness

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