Ultrastructural analysis of bone formation around dental implants in nondiabetic rats, severe diabetics not controlled and controlled with insulin

Souza, Augusto César Rodrigues de; Tedesco, B; Lourenção, Pedro Luiz Toledo de Arruda; Terra, Simone Antunes; Araújo, Carlos dos Reis Pereira de; Spadella, César Tadeu; Ortolan, Érika Veruska Paiva

doi:10.1590/acb351101

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…The fibrointegration (i.e., indirect contact by the interposition of the fibrous tissue between the recipient bed and functional implant) has been observed by SEM analysis 15 , 21 . With this technique, indirect osseointegration between the recipient bed and the PMMA of all implanted tibia was observed ( Figs.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, during destructive mechanical tests, this composite has shown resistance similar to the one of bone tissue 16 . However, high-resolution morphological analysis of the interface between this biomaterial and the receiving bed is necessary to observe adaptations and properties of inorganic or organic tissues with different densities, which is a fundamental factor to understand the local bone biology 15 , 16 , 20 .…”

Section: Introductionmentioning

confidence: 99%

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Integration of heterologous bone matrix associated with polymethylmethacrylate in induced tibial bone defects. An experimental study in rabbits

et al. 2021

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Purpose To analyze and compare the reactions at the interface between the composite, composed of fragmented heterologous mineralized bone matrix (MOMHF) and polymethylmethacrylate (PMMA), and the rabbit’s tibias, through macroscopic evaluation and scanning electron microscopy (SEM) in different periods. Methods In this study, 12 New Zealand adult rabbits were used (E1: n = 3, E2: n = 3, E3: n = 3 and E4: n = 3). They had the right tibial defects filled with composite and were evaluated immediately after surgery and at 30, 60, 90, and 120 days. Results The composites were incorporated and integrated into the recipient beds in 100% of the cases, defined by the MOMHF osseointegration and the PMMA fibrointegration, with no sign of infection, migration, or rejection. Conclusions The behavior of the composites in the recipient beds demonstrates that these biomaterials have the potential to be used in bone defect repairs, offering, thus, better quality of life to the orthopedic patient.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integration of heterologous bone matrix associated with polymethylmethacrylate in induced tibial bone defects. An experimental study in rabbits

et al. 2021

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“…In this study, non-insulin-treated and implanted diabetic rats exhibited a loose bone matrix with loose aspect, irregular arrangement, thin trabeculae, empty spaces and large amounts of proteoglycans. 22 In a recent observational study, Alshahrani et al showed that cortical bone loss (CBL) levels in patients with uncontrolled T2DM were significantly higher than in pre-diabetic, controlled diabetic, and non-diabetic patients. In a clinical study also reported that cortical bone thickness showed a positive correlation with local ISQ values, and cortical bone loss caused a decrease in implant stability resulting in a decrease in ISQ values.…”

Section: Isq Examination As a Support For The Successful Of Dental Im...mentioning

confidence: 99%

An Overview of Type 2 Diabetes Mellitus (T2DM): Dental Implant Survival Rates

Kuntjoro

Hendrijantini

Dahlan

et al. 2022

ijp

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Background: Dental implants are an alternative treatment to replace missing teeth, as it is one of the oral health problems in the elderly. The success of dental implants is affected by a process known as osseointegration. Systemic conditions such as T2DM can interfere with the osseointegration process which can lead to implant failure. As the patient's blood glucose level increases, it will increase the accumulation of AGEs. These AGEs will interfere with the stages of bone-implant contact and also bone growth around the implant Objectives: To review dental implant survival rates in T2DM patients based on HbA1c, ISQ and CBCT examinations. Conclusion: Dental implants in T2DM patients after being evaluated for 2 years showed a good result. This result is obtained with the condition that HbA1c control is below 8%. Another solution to support the success of dental implants placement in T2DM patients is the use of delayed insertion technique and modification of the implant surface with HA or SLA is also recommended. Evaluation of implant success can also be done with pre-operative planning, such as evaluation of the bone condition with ISQ and CBCT examinations.

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Ultrastructural analysis of bone formation around dental implants in nondiabetic rats, severe diabetics not controlled and controlled with insulin

Cited by 2 publications

References 25 publications

Integration of heterologous bone matrix associated with polymethylmethacrylate in induced tibial bone defects. An experimental study in rabbits

Integration of heterologous bone matrix associated with polymethylmethacrylate in induced tibial bone defects. An experimental study in rabbits

An Overview of Type 2 Diabetes Mellitus (T2DM): Dental Implant Survival Rates

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