Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study

Federige, Marco Aurélio Ferreira; Romaldini, João Hamilton; Miklos, Ana Beatriz Pinotti Pedro; Koike, Márcia Kiyomi; Takei, Kioko; Portes, Evandro de Souza

doi:10.1590/2359-3997000000309

Cited by 16 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the HT patients as a whole, the mean Se-level was 22% lower compared to that of the control group. The extent of difference in Se levels between HT patients and the controls is in agreement with previous investigations reporting diminished Se-status in other inflammatory diseases [18,20,[37][38][39]. Wimmer et al [37] compared the Se-level of autoimmune thyroiditis patients with matched controls.…”

Section: Discussionsupporting

confidence: 87%

Serum Selenium Status and Its Interrelationship with Serum Biomarkers of Thyroid Function and Antioxidant Defense in Hashimoto’s Thyroiditis

et al. 2020

View full text Add to dashboard Cite

Selenium (Se) deficiency has been implicated in the pathogenesis of Hashimoto’s thyroiditis (HT), although the available evidence is limited. The present study aimed to explore the interrelationships between serum Se status with measures of thyroid function and antioxidant defense in new cases of HT patients with hypoechogenic thyroid. HT patients (n = 49) and matched controls (n = 50) were recruited. Selenium, thyroid hormone panel, thyroid volume (TVol), glutathione (GSH), glutathione peroxidase3 (GPx3) activity, urinary iodine concentration (UIC), and urinary creatinine (Cr) were assessed. HT patients exhibited lower Se levels compared to controls (p < 0.001) with the rates of Se-deficient (<0.85 µmol/L) participants being 58.8% and 34%, respectively. Se-deficient patients exhibited higher thyroid stimulating hormone (TSH), Thyroid volume (TVol), thyroglobulin, antibody-titers, GPx3 activity and UIC/Cr compared to Se-sufficient patients (all p < 0.001). In the Se-deficient patients, inverse correlations were seen between Se-levels with TSH, TVol, and Thyroid peroxidase antibody (TPO-Ab) (all p < 0.001). This study is the first to uncover that coexisting Se-deficiency and elevated iodine in HT may enhance autoimmune reactions and accelerate the deterioration of thyroid function through oxidative stress. Our study also highlights the importance of optimal Se status in this disease, thus providing a rationale for the execution of intervention trials for the evaluation of the clinical benefits of antioxidant-status improvement in HT.

show abstract

Section: Discussionsupporting

confidence: 87%

Serum Selenium Status and Its Interrelationship with Serum Biomarkers of Thyroid Function and Antioxidant Defense in Hashimoto’s Thyroiditis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…There are several studies revealing that low levels of SeS express inflammatory reactions leading to a subsequent increase in the consumption of Se-dependent proteins, with serious consequences for the ROS–antioxidant balance. The oxidative stress, indicated by low SeS values, may be linked to a series of autoimmune inflammatory-based pathologies [ 56 ]: autoimmune thyroid disease [ 57 , 58 , 59 ], vitiligo [ 60 , 61 ], rheumatoid arthritis [ 62 ], and systemic lupus erythematous [ 63 ]. Thus, SeS status can be considered an appropriate biomarker for these types of pathologies.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania

et al. 2021

View full text Add to dashboard Cite

Selenium, residing in a series of selenoproteins, plays an important role in both female and male reproductive function. Of particular significance for reproduction is the antioxidant glutathione peroxidase (GPx), a main selenoenzyme, whose level is regulated by the availability of Se in the body. We hypothesized that changes in Se status, closely related to GPx activity, would result in an increased risk of reproductive dysfunction in individuals. We retrospectively investigated the serum selenium (SeS) concentrations of 1264 apparently healthy people, aged 16–89 years, from Western Romania. The general analysis revealed a non-normal SeS distribution with a median SeS of 100.26 ± 18.32 μg/L and a significant difference in SeS levels between age groups. The analysis of the young group (16–35 years) revealed that up to 50% of individuals did not reach the SeS threshold corresponding to maximum GPx activity (80 μg/L), and a significant imbalance between the genders was apparent when looking at SeS values outside the range. Our results correlated with the general diminished reproductive ability registered in Romania during the last few years. Serum selenium content proves to offer a proper reflection of the fertility competence of the young population, and its monitoring is important for guiding dietary adjustments and attaining normal reproductive function.

show abstract

“…23 Selênio O selênio (Se) é fundamental para o metabolismo celular, pois é incorporado por um grupo de proteínas importantes conhecidas como selenoproteínas, cada uma das quais desempenha um papel crítico no metabolismo tireoidiano. 24 A tireoide é caracterizada por uma alta concentração de Se (0,2 μg/g a 2 μg/g), sendo o órgão com maior quantidade de Se por grama de tecido, pois contém a maioria das selenoproteínas. 25 As principais selenoproteínas, glutationa peroxidase 3 (GSH-Px3), tioredoxina redutase e deiodinases, são expressas nos tireócitos em grandes quantidades.…”

Section: Gestantesunclassified

“…25 E em pacientes com diagnóstico de tireoidite de Hashimoto (TH) e doença de Graves (DG), baixos níveis séricos de selenoproteínas podem representar reações inflamatórias, com consequente aumento no consumo de proteínas dependentes de Se, na tentativa de prevenir a produção dos radicais livres gerados pela agressão autoimune tireoidiana. 24 Parshukova et al, 28 estudando as inter-relações entre níveis sazonais de Se e níveis de hormônios da tireoide ao longo de um ano, verificaram que níveis séricos baixos de Se afetavam os níveis dos hormônios tireoidianos. Além disso, Wu et al 29 realizaram um estudo em que se investigou a prevalência da doença tireoidiana em duas regiões semelhantes, exceto pela grande diferença nas concentrações de Se no solo.…”

Section: Gestantesunclassified

“…Portanto, segundo os autores, os dados corroboram o vínculo postulado entre a oferta inadequada de selênio e a doença tireoidiana autoimune, especialmente a DG. No entanto, em um estudo realizado em São Paulo, Federige et al, 24 ao investigar os níveis séricos de Se em pacientes com DG com e sem oftalmopatia de Graves (OG) e TH, encontraram que a concentração sérica de Se foi menor do que em alguns outros países, mas não significativa entre os pacientes com doença autoimune da tireoide.…”

Section: Gestantesunclassified

See 1 more Smart Citation

Micronutrient Influence in Thyroid Function: A Review

Nóbrega

2019

International Journal of Nutrology

View full text Add to dashboard Cite

The thyroid produces and secretes adequate amounts of hormones that regulate various physiological processes, including growth, development, metabolism, and reproductive function. The production and metabolism of thyroid hormones are dependent on micronutrients such as iodine, selenium, zinc and iron. Iodine is essential for the proper synthesis of thyroid hormones. The risk of iodine deficiency is high in places where the food consumed comes from iodine-deficient sources. To avoid complications, various government strategies have been developed to enrich food with this element. Selenium is incorporated in the deiodinases, which are enzymes that also play an essential role in the metabolism of thyroid hormones, in addition to contributing to the antioxidant defense in the thyroid. Zinc participates in the process of deiodination, in addition to being necessary for the T3 receptor to adopt its biologically active confirmation. Iron is found in hemeproteins, including thyroid peroxidase (TPO), which participates in the first two stages of thyroid hormone biosynthesis. Deficiencies of these elements can impair thyroid function. In general, the influence of micronutrients on thyroid function reveals the need for more research to increase scientific knowledge so that preventive and therapeutic measures can be taken regarding thyroid dysfunctions, to maintain a healthy thyroid.

show abstract

Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study

Abstract: A serum Se concentration was lower than in some other countries, but not significantly among AITD patients. The low serum SePP levels in GO and HT patients seems to express inflammatory reactions with a subsequent increase in Se-dependent protein consumption remains unclear.

Cited by 16 publications

References 33 publications

Serum Selenium Status and Its Interrelationship with Serum Biomarkers of Thyroid Function and Antioxidant Defense in Hashimoto’s Thyroiditis

Serum Selenium Status and Its Interrelationship with Serum Biomarkers of Thyroid Function and Antioxidant Defense in Hashimoto’s Thyroiditis

Evaluation of Serum Selenium Status by Age and Gender: A Retrospective Observational Cohort Study in Western Romania

Micronutrient Influence in Thyroid Function: A Review

Contact Info

Product

Resources

About