The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome

Tabak, Ömür; Şimşek, Gönül; Erdenen, Füsun; Sözer, Volkan; Hasoglu, Tuna; Gelışgen, Remise; Altunoğlu, Esma; Müderrisoğlu, Cüneyt; Şenyiğit, Abdülhalim; Uzun, Hafize

doi:10.1590/2359-3997000000289

Cited by 31 publications

(21 citation statements)

References 24 publications

(17 reference statements)

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“…In the present study, reduced circulating levels of TNFα and hsCRP were detected after dietary weight loss intervention. In addition, lower levels of RBP4, an adipokine contributing to systemic IR and recently associated with hsCRP in the progression of metabolic syndrome [33], were detected. As a whole, inflammatory parameters were reduced after weight loss, suggesting a reduction in systemic inflammation mediated by caloric restriction.…”

Section: Discussionmentioning

confidence: 96%

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity

López‐Domènech

Abad-Jiménez

Iannantuoni

et al. 2019

Molecular Metabolism

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ObjectiveIn obese patients undergoing caloric restriction, there are several potential mechanisms involved in the improvement of metabolic outcomes. The present study further explores whether caloric restriction can modulate endoplasmic reticulum (ER) stress and mitochondrial function, as both are known to be mechanisms underlying inflammation and insulin resistance (IR) during obesity.MethodsA total of 64 obese patients with BMI ≥35 kg/m2 underwent a dietary program consisting of 6 weeks of a very-low-calorie diet followed by 18 weeks of low-calorie diet. We evaluated changes in the metabolic and inflammatory markers -TNFα, hsCRP, complement component 3 (C3c), and retinol binding protein 4 (RBP4)-, in the ER stress markers and modulators -eIF2α-P, sXBP1, ATF6, JNK-P, CHOP, GRP78, and SIRT1-, and in mitochondrial function parameters -mitochondrial reactive oxygen species (mROS), glutathione peroxidase 1 (GPX1), cytosolic Ca2+, and mitochondrial membrane potential.ResultsThe dietary intervention produced an 8.85% weight loss associated with enhanced insulin sensitivity, a less marked atherogenic lipid profile, and a decrease in systemic inflammation (TNFα, hsCRP) and adipokine levels (RBP4 and C3c). Chronic ER stress was significantly reduced (ATF6-CHOP, JNK-P) and expression levels of SIRT1 and GRP78 – a Ca2+-dependent chaperone – were increased and accompanied by the restoration of Ca2+ depots. Furthermore, mROS production and mitochondrial membrane potential improvement were associated with the up-regulation of the antioxidant enzyme GPX1.ConclusionsOur data provide evidence that moderate weight loss attenuates systemic inflammation and IR and promotes the amelioration of ER stress and mitochondrial dysfunction, increasing the expression of chaperones, SIRT1 and antioxidant GPX1.

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Section: Discussionmentioning

confidence: 96%

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity

López‐Domènech

Abad-Jiménez

Iannantuoni

et al. 2019

Molecular Metabolism

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“…Irisin may indicate a potentially novel therapeutic approach in the field of obesity and diabetes [ 6 ]. Circulating irisin level was reported to increase in the patients with metabolic syndrome compared with healthy controls [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus

Xuan¹,

Lin²,

Zhang³

et al. 2020

J Clin Med Res

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Background The aim of this study is to evaluate the level and role of serum irisin in elderly patients with type 2 diabetes mellitus (T2DM) using case-control study. Methods A total of 71 patients with T2DM were selected as the case group according to the inclusion criteria and exclusion criteria; and the ratio of 1:1 was calculated according to the inclusion rate of the residents. The cohort established in Guankou Town, Jimei District, Xiamen City, Fujian Province, China and the residents of this cohort were selected at the age of 60 and above. A total of 71 healthy subjects were included as the control group with the same gender and the age with a difference of ± 5 years old. The clinical data of the subjects were collected to determine their previous history, blood pressure, body mass index (BMI), hemoglobin (HB), liver function test, renal function test, fasting blood glucose and serum lipid. The irisin level in serum was measured by enzyme-linked immunosorbent assay (ELISA). The data were analyzed by using SPSS17.0 software. Single factor analysis using Chi-square test or t -test was performed to compare the differences between T2DM patients with the control group of the general data, clinical indicators and irisin level in serum. Logistic regression was used to analyze the protective factors and risk factors of diabetes mellitus. Results The results of single factor analysis showed that the level of irisin in T2DM group was significantly lower than that in the control group (703.37 ± 241.51 ng/mL and 800.22 ± 275.59 ng/mL, respectively). The levels of BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG) and fasting plasma glucose (FPG) in T2DM group were higher than those in control group, and differences were statistically significant. Logistic regression analysis indicated that irisin may be a protective factor for type 2 diabetes (odds ratio (OR) = 0.997, 95% confidence interval (CI): 0.994 - 0.999). Conclusions The serum irisin level in T2DM group was significantly lower than that in control group, suggesting that irisin may be a protective factor for type 2 diabetes.

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“…2 When analysed the association between irisin and metabolic syndrome (MetS), a combination of various medical disorders including obesity and insulin resistance, higher circulating irisin levels in patients with MetS were also reported, when compared with patients without MetS. 25,39,58,59 Once again, caution needs to be taken in the analysis of these results; besides the controversy around irisin's detection methods, different studies protocols were performed and heterogeneous populations analysed, some of them with co-morbidities associated and others not.…”

Section: Irisin and Metabolic Diseasesmentioning

confidence: 99%

Irisin: A bright or a dark future?

Pereira¹,

Pinho²,

Carvalho³

et al. 2019

Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo

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Seven years ago, irisin was fi rst announced as a new and exciting myokine, which was secreted by the skeletal muscle in response to exercise and contributed for some of the health benefi ts promoted by physical activity. It was suggested that exercise stimulates the increase of the amount of the coactivator PGC-1α, which subsequently increases the expression of FNDC5, a membrane protein that is proteolytically cleaved to form irisin. Once released into the bloodstream, irisin connects to a yet unknown receptor on the surface of white fat cells and promotes a special process known as "browning" of white adipose tissue, which increases thermogenesis and the energy expenditure. Since its discovery, great hopes have been raised, and the association between irisin and these abovementioned functions led this myokine to be considered a potential therapeutic weapon in the fi ght against obesity and other related metabolic disorders, such as diabetes. However, concerns about its presence, regulation and the yet-to-be fully understood functions associated with inconstant results, put the future of irisin in doubt. Therefore, caution needs to be taken in expressing optimism, and the near future will be a challenge for irisin's ability to survive as a useful tool in the treatment of metabolic diseases. Meanwhile, new associations between irisin, neoplastic, cardiovascular and neurodegenerative diseases are being deduced and further studies will help to clarify the role of irisin in humans.

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The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome

Cited by 31 publications

References 24 publications

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity

Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus

Irisin: A bright or a dark future?

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