Clinical and laboratory characteristics of patients with thyroid diseases with and without alanine aminotransferase levels above the upper tertile – Cross-sectional analytical study

Abstract

Objective: Thyroid disease affects 6.6% of the general population. The liver is fundamental in metabolizing thyroid hormones, and hepatocytes are often affected in thyroid disease. We aimed to compare clinical and laboratory parameters among thyroid disease patients with alanine aminotransferase (ALT) levels above vs. below the upper tertile. Subjects and methods: A retrospective cross-sectional analytical study was conducted in the endocrinology clinic at Polydoro Ernani de São Thiago University Hospital. Patients with thyroid disease between August 2012 and January 2014 were included in the study. Clinical and laboratory parameters were collected from medical records. Results: One hundred patients were included, of which 14.0% were male, with a mean age of 49.1 ± 14.4 years. ALT levels ranged from 9 to 90 U/L, and the ALT upper tertile was defined as 0,64 times the upper normal limit (xUNL). Patients with ALT levels above the upper tertile exhibited a higher proportion of systemic arterial hypertension (SAH), a higher mean abdominal circumference and a higher frequency of elevated TSH levels than did patients with ALT levels below the upper tertile. In multivariate analysis, ALT ≥ 0.64 (xUNL) was independently associated with abdominal circumference (odds ratio [OR] = 0.087, 95% confidence interval [CI] 0012-0167, P = 0.022). ALT (xUNL) correlated positively with total cholesterol (r = 0.213, P = 0.042). Conclusions: In patients with thyroid diseases, it was observed that those with ALT above the upper tertile are associated with abdominal circumference and ALT levels correlate with total cholesterol. Arch Endocrinol Metab. 2016;60(2):101-7

Comparative efficacy of early morning versus bedtime administration of levothyroxine in children with hypothyroidism: a prospective, open label, randomized, case-control study

“…A reassuring finding in our study was the lack of adverse effects of shifting of levothyroxine timing at the tissue level, as reflected by normal serum concentrations of liver enzymes, lipids and creatinine at the follow-up visits. Elevation of liver enzymes, specifically ALT, is a marker of uncontrolled hypothyroidism [23,24]. Similarly, dyslipidemia, is often a reflection of poor control of hypothyroid state even when the serum TSH is apparently in the normal ranges [25][26][27].…”

Cooperation Between Data Analysts and Medical Experts: A Case Study

“…The prevalence of hypothyroidism and hyperthyroidism is different between women and men. Hyperthyroidism is prevalent in 0.5 -2 % of women and 0.1 -0.2 % of men, whereas hypothyroidism occurs in 0.06 -1.2 % in women and 0.1 -0.4 % in men [4]. Hypothyroidism [5] is a common endocrine disorder, and it affects hundreds of millions around the world.…”

Apoptosis and Cell Cycle Pathway-Focused Genes Expression Analysis in Patients with Different Forms of Thyroid Pathology

“…Thyroid disorders affect approximately 6.6% of the world population. In the Central, Northern, and Eastern Europe, there is a recorded increasing incidence of such disorders since the Chernobyl nuclear accident in 1986 [1]. The most prevalent autoimmune thyroid disorder, Hashimoto's thyroiditis (HT), results in lymphocytic infiltration of the thyroid gland, often followed by gradual destruction and fibrous replacement of the thyroid parenchymal tissue.…”