Reassessing lipid metabolism and its potentialities in the prediction of cardiovascular risk

Silva, Isis Tande da; Almeida-Pititto, Bianca de; Ferreira, Sandra Roberta Gouvêa

doi:10.1590/2359-3997000000031

Cited by 15 publications

(6 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24 Herein, the apoB/apo-A1 ratio reflects the probability of potential arteriosclerosis and lipid disturbances, and this ratio has been proposed to predict cardiovascular risk. 25,26 Additionally, it has been reported that the ratio of apoB/ apo-A1 is associated with the incidence of visceral adiposity. 27 Our findings show that decreases in apo-A1 and increases in apoB and the apoB/apo-A1 ratio were found in HF-fed mice and that supplementation with ISO strongly reversed the effect of HF on apo-A1, apoB, and the apoB/apo-A1 ratio (Figure 2A−C).…”

Section: ■ Discussionmentioning

confidence: 99%

Isoorientin Prevents Hyperlipidemia and Liver Injury by Regulating Lipid Metabolism, Antioxidant Capability, and Inflammatory Cytokine Release in High-Fructose-Fed Mice

Han

et al. 2016

J. Agric. Food Chem.

View full text Add to dashboard Cite

Isoorientin (ISO), a natural flavonoid, has been found to have multiple biological properties. In the present study, obese mice with high-fructose (HF)-induced liver injury were used to investigate the hepatoprotective effects of ISO. The results showed that ISO significantly reduced the serum lipid parameters in mice fed 20% HF water. Meanwhile, ISO appeared to alleviate HF-induced lipid metabolic disorders by increasing the serum levels of apo-A1 and decreasing the serum apoB levels, apoB/apo-A1 ratio, and FAS activity in the liver. ISO also remarkably ameliorated HF-induced hepatic oxidative injury and inflammation by decreasing ALT, AST, and ALP levels; enhancing antioxidant enzyme activities; and inhibiting inflammatory cytokine (TNF-α, IL-1, IL-6) release. Histopathology of liver stained by H&E and Oil Red O showed the liver steatosis and oxidative injury after HF treatment and the protective effect of ISO. Furthermore, aortic pathology observation found that ISO had a protective effect on the vascular endothelium. This is the first report that ISO efficiently inhibited HF-induced hyperlipidemia and liver injury by ameliorating lipid metabolism, enhancing the antioxidant defensedefense system, and regulating the secretion of inflammatory cytokines.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Isoorientin Prevents Hyperlipidemia and Liver Injury by Regulating Lipid Metabolism, Antioxidant Capability, and Inflammatory Cytokine Release in High-Fructose-Fed Mice

Han

et al. 2016

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…One-fourth to one-third of blood cholesterol can be transported by HDL. Thus, an optimal HDL level may protect against heart attack and stroke, while low HDL levels are reported to increase the incidence of coronary heart disease (CHD) [53].…”

Section: Hdl-cmentioning

confidence: 99%

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

2020

View full text Add to dashboard Cite

Menopause is clinically diagnosed as a condition when a woman has not menstruated for one year. During the menopausal transition period, there is an emergence of various lipid metabolic disorders due to hormonal changes, such as decreased levels of estrogens and increased levels of circulating androgens; these may lead to the development of metabolic syndromes including cardiovascular diseases and type 2 diabetes. Dysregulation of lipid metabolism affects the body fat mass, fat-free mass, fatty acid metabolism, and various aspects of energy metabolism, such as basal metabolic ratio, adiposity, and obesity. Moreover, menopause is also associated with alterations in the levels of various lipids circulating in the blood, such as lipoproteins, apolipoproteins, low-density lipoproteins (LDLs), high-density lipoproteins (HDL) and triacylglycerol (TG). Alterations in lipid metabolism and excessive adipose tissue play a key role in the synthesis of excess fatty acids, adipocytokines, proinflammatory cytokines, and reactive oxygen species, which cause lipid peroxidation and result in the development of insulin resistance, abdominal adiposity, and dyslipidemia. This review discusses dietary recommendations and beneficial compounds, such as vitamin D, omega-3 fatty acids, antioxidants, phytochemicals—and their food sources—to aid the management of abnormal lipid metabolism in postmenopausal women.

show abstract

“…In the non-pregnant state, high serum concentrations of total cholesterol (TC), triglycerides (TG) and low-density lipid cholesterol (LDL-C), and a reduction in serum high-density lipoprotein (HDL-C), are amongst the features of dyslipidaemia related to metabolic syndrome, and they are associated with an increased risk of cardiovascular disease later in life [ 11 , 12 ]. However, there is no consensus as to what constitutes normal maternal lipid values during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Recommended reference values for serum lipids during early and middle pregnancy: a retrospective study from China

et al. 2018

View full text Add to dashboard Cite

BackgroundDisturbances in maternal lipid metabolism have been shown to increase the risk of adverse pregnancy outcomes. However, there is no consensus as to what constitutes normal maternal lipid values during pregnancy. Thus, the aim of this study was to establish serum lipid reference ranges during early and middle pregnancy.MethodsWe conducted a retrospective survey in Beijing from 2013 to 2014. A total of 17,610 singleton pregnancies with lipid data from early and middle pregnancy were included. First, after excluding women with adverse pregnancy outcomes, we performed a descriptive analysis of total cholesterol (TC), triglycerides (TG), high-density lipid cholesterol (HDL-C) and low-density lipid cholesterol (LDL-C) levels using means and standard deviations to determine appropriate percentiles. Second, in the total population, we examined the lipid levels in different trimesters with the risk of adverse pregnancy outcomes using categorical analyses and logistic regression models. Third, we determined the lipid reference range in early and middle pregnancy based on the first two results. Finally, based on the reference ranges we determined, we assessed whether the number of abnormal lipid values affected the risk of adverse pregnancy outcomes.Results(1) Serum levels of TC, TG, LDL-C and HDL-C all increased significantly from early to middle pregnancy, with the greatest increase in TG. (2) A trend towards an increasing incidence of adverse pregnancy outcomes was observed with increasing levels of TC, TG, and LDL-C and decreasing levels of HDL-C in both early and middle pregnancy. (3) We recommend that serum TC, TG and LDL-C reference values in early and middle pregnancy should be less than the 95th percentiles, whereas that of HDL-C should be greater than the 5th percentile, i.e., in early pregnancy, TC < 5.64 mmol/L, TG < 1.95 mmol/L, HDL-C > 1.23 mmol/L, and LDL-C < 3.27 mmol/L, and in middle pregnancy, TC < 7.50 mmol/L, TG < 3.56 mmol/L, HDL-C > 1.41 mmol/L, and LDL-C < 4.83 mmol/L. (4) Higher numbers out-of-range lipids during early and middle pregnancy were correlated with a higher risk of adverse pregnancy outcomes.ConclusionsThe reference ranges recommended in this paper can identify pregnant women with unfavourable lipid values.

show abstract

Reassessing lipid metabolism and its potentialities in the prediction of cardiovascular risk

Cited by 15 publications

References 70 publications

Isoorientin Prevents Hyperlipidemia and Liver Injury by Regulating Lipid Metabolism, Antioxidant Capability, and Inflammatory Cytokine Release in High-Fructose-Fed Mice

Isoorientin Prevents Hyperlipidemia and Liver Injury by Regulating Lipid Metabolism, Antioxidant Capability, and Inflammatory Cytokine Release in High-Fructose-Fed Mice

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

Recommended reference values for serum lipids during early and middle pregnancy: a retrospective study from China

Contact Info

Product

Resources

About