Phonological acquisition in children with early-treated congenital hypothyroidism: association with clinical and laboratory parameters

Dassiê-Leite, Ana Paula; Behlau, Mara; Nesi-França, Suzana; Cat, Mônica Nunes Lima; Lacerda, Luiz de

doi:10.1590/2317-1782/20182018013

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…[31][32][33][34] In the current study, the children with thyroid agenesis had higher occurrence of language deficit and lower IQ in comparison to other CH children with different etiologies, in agreement with previous studies. [35][36][37][38] A previous study conducted with 100 children with CH and 100 children without the disease, reported that children with thyroid agenesis had a higher frequency of phonological deviation compared with those with other CH etiologies. 37…”

Section: Discussionmentioning

confidence: 99%

Thyroid scintigraphy indications based on clinical experience

Elsayeed¹,

Ali²,

Ahmed³

et al. 2019

Egyptian Journal of Neck Surgery and Otorhinolaryngology

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Objective: Thyroid scintigraphy (TS) offers valuable information on thyroid anatomy and functional state of the gland. It is currently employed in both diagnosis and management of thyroid disorders. Data of 440 patients with thyroid disorders referred to thyroid scintigraphy at Sohag University Hospital has been analyzed in this study. Diagnostic contribution and indication of TS to thyroid disorders in adult and children have been assessed. Methods: It is a hospital-based cross-sectional descriptive study where all cases referred for TS at Sohag Institute Nuclear Medicine Unit from the 1 st of November 2015 to the 31 th of October 2018 were considered. Results: Four hundred forty patients were referred to our unit with 84% female. The mean patient's age was 43.0 years. Sixty percent of the patients were referred for thyroid scan due to primary toxic goiter (Grave's disease), the second indication was post-thyroidectomy especially in differentiated thyroid cancer to estimate residual cancer thyroid and starting radioactive iodine treatment. Conclusion: Thyroid scintigraphy is an integral part of thyroid evaluation. However, it has been shown to be of small practical use in euthyroid patients with diffuse or multinodular goiters, or adult patients with hypothyroidism. It has great diagnostic and prognostic roles in congenital hypothyroidism. This emphasizes the importance of increasing the clinicians' awareness of TS when indicated and when not necessarily needed.

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Section: Discussionmentioning

confidence: 99%

Thyroid scintigraphy indications based on clinical experience

Elsayeed¹,

Ali²,

Ahmed³

et al. 2019

Egyptian Journal of Neck Surgery and Otorhinolaryngology

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“…Language development is also altered in children with CH-Tx. Several reports show the presence of phonological deficits and significant delays in the development of expressive and receptive language in infants [ 68 , 69 , 70 , 71 ]; this is even clearer in children whose hypothyroidism is not properly controlled [ 72 ]. The scores obtained show that children with CH-Tx, specifically those aged 6 and 7 years, have a delay in phonological acquisition compared with the control groups [ 69 ].…”

Section: Neuropsychological Alterations In Ch-txmentioning

confidence: 99%

“…Several reports show the presence of phonological deficits and significant delays in the development of expressive and receptive language in infants [ 68 , 69 , 70 , 71 ]; this is even clearer in children whose hypothyroidism is not properly controlled [ 72 ]. The scores obtained show that children with CH-Tx, specifically those aged 6 and 7 years, have a delay in phonological acquisition compared with the control groups [ 69 ]. Cooper et al demonstrated that school children and adolescents (age 6–15 years) with CH-Tx have lower communication capacity than controls, although within normal limits [ 52 ].…”

Section: Neuropsychological Alterations In Ch-txmentioning

confidence: 99%

“…Díaz et al [ 56 ] emphasized that the etiology of agenesis reduces the total IQ score by 11.6 points; in fact, there is a greater frequency of patients with an IQ that reaches mental deficiency, borderline, or normal clumsy. A greater deficit in speech and expressive and receptive language has been reported, along with a greater frequency of phonological deviation in patients with agenesis [ 39 , 69 ]. Regarding sensorimotor and visuospatial domains, patients with CH due to agenesis show deficient performance in eye-hand coordination, locomotion, and perceptual area compared with children with CH due to ectopia or dyshormonogenesis.…”

Section: Factors Contributing To the Establishment Of Neuropsychologi...mentioning

confidence: 99%

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Neuropsychological Alterations in Patients with Congenital Hypothyroidism Treated with Levothyroxine: Linked Factors and Thyroid Hormone Hyposensitivity

Razón-Hernández

Osnaya-Brizuela

Valenzuela-Peraza

et al. 2022

JCM

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Eighty-five percent of the studies of patients with congenital hypothyroidism (CH) treated with Levothyroxine (L-T4) report neuropsychological sequelae throughout life. In neonates and infants, there is a deficit in sensorimotor skills (impaired balance). In preschool and elementary school children and adolescents, there are alterations in intellectual quotient (low scores), language (delayed phonological acquisition), memory (visual, verbal, visuospatial, visuoconstructive, autobiographical, and semantic), sensorimotor skills (impaired fine and gross motor control), and visuoconstructive–visuospatial domain (low scores in spatial location, block design, and object assembly). These neuropsychological domains are also affected in young adults, except for language (adequate verbal fluency) and visuoconstructive–visuospatial domain (no data). The onset and severity of neuropsychological sequelae in patients with treated CH depend on several factors: extrinsic, related to L-T4 treatment and social aspects, and intrinsic, such as severity and etiology of CH, as well as structural and physiological changes in the brain. In this review, we hypothesized that thyroid hormone hyposensitivity (THH) could also contribute to neuropsychological alterations by reducing the effectiveness of L-T4 treatment in the brain. Thus, further research could approach the THH hypothesis at basic and clinical levels to implement new endocrinological and neuropsychological therapies for CH patients.

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Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism

Büyükavcı

Dündar

2023

Journal of Pediatric Endocrinology and Metabolism

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Objectives Congenital hypothyroidism (CH) is still one of the most common causes of preventable cognitive impairment in children, and its early detection and treatment prevent irreversible neurodevelopmental delay. Depending on the underlying cause, cases with CH may be transient or permanent. This study aimed to compare the developmental evaluation results of transient and permanent CH patients and to reveal any differences. Methods A total of 118 patients with CH, who were followed up jointly in pediatric endocrinology and developmental pediatrics clinics, were included. The patients’ progress was evaluated per the International Guide for Monitoring Child Development (GMCD). Results Of the cases, 52 (44.1%) were female, and 66 (55.9%) were male. While 20 (16.9%) cases were diagnosed with permanent CH, 98 (83.1%) were diagnosed with transient CH. According to the results of the developmental evaluation made with GMCD, the development of 101 (85.6%) children was compatible with their age, while 17 (14.4%) children had delays in at least one developmental area. All 17 patients had a delay in expressive language. Developmental delay was detected in 13 (13.3%) of those with transient CH and 4 (20%) with permanent CH. Conclusions There is difficulty in expressive language in all cases of CH with developmental delay. No significant difference was found between the developmental evaluations of permanent and transient CH cases. The results revealed the importance of developmental follow-up, early diagnosis and interventions in those children. GMCD is thought to be an important guide to help monitoring the development of patients with CH.

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Phonological acquisition in children with early-treated congenital hypothyroidism: association with clinical and laboratory parameters

Cited by 3 publications

References 21 publications

Thyroid scintigraphy indications based on clinical experience

Thyroid scintigraphy indications based on clinical experience

Neuropsychological Alterations in Patients with Congenital Hypothyroidism Treated with Levothyroxine: Linked Factors and Thyroid Hormone Hyposensitivity

Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism

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