Is bipolar disorder associated with premature aging?

Brietzke, Elisa; Cerqueira, Raphael O.; Soares, Cláudio N.; Kapczinski, Flávio

doi:10.1590/2237-6089-2019-0038

Cited by 7 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, cardiovascular diseases are responsible for nearly 40% of deaths among BD patients (5). These health issues are attributed to the disease's inherent pathophysiological mechanisms, such as systemic factors like brain and bodily immune inflammation, glucose-insulin imbalances, oxidative stress imbalance, mitochondrial dysfunction, premature or accelerated aging, as well as the side effects of medications and unhealthy lifestyles (6)(7)(8)(9)(10)(11). Diet, nutritional patterns and specific nutrients may have an impact on these mechanisms, such as excessive sugar intake causing oxidative stress and inflammation, and omega-3 fatty acids have anti-inflammatory activity and affect neuroplasticity (12,13).…”

Section: Introductionmentioning

confidence: 99%

Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study

Li,

Hu,

Luo

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundDiet/nutrition is critically important in the pathogenesis, progression, and treatment outcomes of various mental disorders. Current research predominantly focuses on the role of diet in the development and treatment of depression, with less attention given to the relationship between diet and Bipolar Disorder (BD).MethodWe employed Mendelian Randomization (MR) to investigate the relationship between 28 dietary habits and BD. An analysis was conducted using publicly available genome-wide association study data from the UK Biobank dataset. Various dietary habits were analyzed as exposures with BD as the outcome, mainly using the Inverse Variance Weighted (IVW) method.ResultsIntake of non-oily fish and sponge pudding both have a positive association with BD. Oily fish, dried fruit, apples, salt, and cooked vegetables intake also appeared potentially risky for BD, although the possibility of false positives cannot be ruled out. Sensitivity analysis further confirmed the robustness of these findings.ConclusionOur research provides evidence of a relationship between various dietary habits and BD. It underscores the need for careful dietary management and balance to reduce the risk of BD, suggesting caution with dietary preferences for fish and sponge pudding. Furthermore, more detailed studies are needed to further understand the potential impacts of high-sugar and high-protein diets on BD development.

show abstract

Section: Introductionmentioning

confidence: 99%

Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study

Li,

Hu,

Luo

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…It has also been described that multiple dimensions of aging seem to be altered in BD, leading to a premature aging process [3]. Older Adults with Bipolar Disorder (OABD) refers to patients older than 50 years with BD [4,5].…”

Section: Introductionmentioning

confidence: 99%

Facing Life in Old Age: Exploring Resilience in Older Adults with Bipolar Disorder

Montejo,

Retuerto,

Sole

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Older adults with bipolar disorder (OABD) are individuals aged 50 years and older with bipolar disorder (BD). People with BD may have fewer coping strategies or resilience. A long course of the disease, such as in OABD, could impact the development of resilience strategies, but this remains under-researched in OABD. Therefore, this study aims to assess resilience levels within the OABD and explore associated factors, hypothesizing that resilience could improve psychosocial functioning, wellbeing and quality of life of OABD patients. Methods: This study sampled 33 OABD patients from the OABD cohort at the Bipolar and Depressive Disorders Unit of Hospital Clinic of Barcelona. This was an observational, descriptive and cross-sectional study. Demographic and clinical variables as well as psychosocial functioning, resilience and cognitive reserve were analyzed. Resilience was measured using the CD-RISC-10. Non-parametric tests were used for statistical analysis. Results: The average CD-RISC-10 score was 25.67 points (SD 7.87). Resilience negatively correlated with the total number of episodes (p = 0.034), depressive episodes (p = 0.001), and the FAST (p < 0.001). Participants with normal resilience had a lower FAST (p = 0.046), a higher CRASH (p = 0.026), and more EOBD (p = 0.037) compared to those with low resilience. Conclusions: OABD individuals may exhibit lower resilience levels which correlate with more psychiatric episodes, particularly the number of depressions and worse psychosocial functioning and cognitive reserve. Better understanding and characterization of resilience could aid in early identification of patients requiring additional support to foster resilience and enhance OABD management.

show abstract

“…In contrast, pathological aging is marked by various physical and mental disorders, usually associated with physiological aging at earlier ages. These alterations are attributed to acute and/or chronic diseases, environmental factors, toxic habits (such as smoking and consumption of alcohol and other drugs), and cancer [15][16][17].…”

Section: Introduction Aging: a Physiological Stage Associated With A Higher Frequency Of Pathologiesmentioning

confidence: 99%

Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds

Figuer

Bodega

Tato

et al. 2021

IJERPH

View full text Add to dashboard Cite

Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and the treatment of chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process characterized by a series of progressive and irreversible physiological changes associated with loss of functional, psychological, and social capabilities. Numerous factors, such as oxidative stress, inflammation, and cellular senescence, and an irreversible geriatric syndrome known as frailty, contribute to human body deterioration in aging. The speed of aging may differ between individuals depending on the presence or absence of multiple factors (genetic and/or environment) and the subsequent misbalance of homeostasis, together with the increase of frailty, which also plays a key role in developing chronic diseases. In addition, pathological circumstances have been reported to precipitate or accelerate the aging process. This review investigated the mechanisms involved in the developing pathologies, particularly chronic kidney disease, associated with aging.

show abstract

Is bipolar disorder associated with premature aging?

Cited by 7 publications

References 36 publications

Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study

Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study

Facing Life in Old Age: Exploring Resilience in Older Adults with Bipolar Disorder

Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds

Contact Info

Product

Resources

About