Transcranial magnetic stimulation for posttraumatic stress disorder: an updated systematic review and meta-analysis

Trevizol, Alisson Paulino; Barros, Mirna Duarte; Silva, Paula Oliveira e; Osuch, Elizabeth A.; Cordeiro, Quirino; Shiozawa, Pedro

doi:10.1590/2237-6089-2015-0072

Cited by 49 publications

(33 citation statements)

References 15 publications

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“…One recent metaanalysis of rTMS for PTSD reviewed 5 randomized control trials (RCTs) concluding that active rTMS was superior to sham stimulation (Trevizol et al 2016). One recent metaanalysis of rTMS for PTSD reviewed 5 randomized control trials (RCTs) concluding that active rTMS was superior to sham stimulation (Trevizol et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The literature on rTMS use for PTSD is limited. One recent metaanalysis of rTMS for PTSD reviewed 5 randomized control trials (RCTs) concluding that active rTMS was superior to sham stimulation (Trevizol et al 2016). Another exploratory meta-analysis (Berlim, Broadbent, & Van den Eynde, 2013) of randomized and sham-controlled studies using DLPFC-rTMS found significantly improved outcomes overall in anxiety and depressive symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open‐label case series

Woodside

Colton

Lam

et al. 2017

Intl J Eating Disorders

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Posttraumatic stress disorder (PTSD) is a common comorbid condition in anorexia nervosa (AN) and bulimia nervosa (BN), and may be associated with reduced response to treatment. We report on a case series employing repetitive transcranial magnetic stimulation (rTMS) with a novel target, the dorsomedial prefrontal cortex (DMPFC). Fourteen subjects with eating disorders and comorbid PTSD received 20-30 neuronavigated DMPFC-rTMS treatments on an open-label basis. PTSD symptoms were assessed pretreatment and posttreatment with the PTSD checklist-Civilian (PCL-C) and the Difficulties in Emotional Regulation Scale (DERS). PCL-C scores were reduced by 51.99% ± 27.24% overall, from a mean of 54.29 ± 19.34 pretreatment to 24.86 ± 17.43 posttreatment (p < .001). Of the 14, 8 showed an improvement of >50%. DERS scores improved by 36.02% ± 24.24% overall, from 140.00 ± 22.09 at pretreatment to 89.29 ± 38.31 at posttreatment (p < .001). OF the 14 subjects, 5 achieved >50% improvement. These data may suggest that DMPFC-rTMS could be helpful in the treatment of PTSD in some ED patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open‐label case series

Woodside

Colton

Lam

et al. 2017

Intl J Eating Disorders

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“…Numerous research studies have also reported benefits for many other neuropsychiatric conditions [10][11][12][13][14][15], and more recent work has sought to combine TMS with behavioral interventions [8,[16][17][18]. While the combination of TMS with other interventions has intrinsic appeal, there is limited scientific value in showing that two therapies, combined, work better than a single therapy, alone.…”

Section: Stimulationmentioning

confidence: 99%

Theta Burst Transcranial Magnetic Stimulation of Fronto-Parietal Networks: Modulation by Mental State

Taylor

Lee

Jonides

et al. 2020

J Psychiatry Brain Sci

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Transcranial magnetic stimulation (TMS) treats neuropsychiatric disorders, but effects of stimulation are highly state-dependent and in most therapeutic applications, mental state is not controlled. This exploratory proposal will test the broad hypothesis that when TMS, specifically intermittent theta burst stimulation (iTBS), is applied during a controlled mental state, network changes will be facilitated, compared to stimulation when mental state is uncontrolled. We will focus on the dorsolateral prefrontal cortex (dlPFC) and the associated fronto-parietal network (FPN), which subserves cognitive control, an important neural and behavioral target of therapeutic TMS. After a baseline functional magnetic resonance imaging (fMRI) session, iTBS will be administered to 40 healthy subjects in three sessions over three days in a within-subjects, cross-over design: (1) dlPFC stimulation by iTBS alone, (2) dlPFC stimulation by iTBS while simultaneously performing a cognitive task, and (3) vertex (control) iTBS stimulation. Immediately after each iTBS session, we will measure blood oxygenation level-dependent (BOLD) activation during a cognitive control task ("n-back" task) and during the resting state, using BOLD connectivity and arterial spin labeling (ASL). We will test hypotheses that persisting neural changes and performance enhancement induced by iTBS to the dlPFC, compared to iTBS to the vertex, will affect the FPN, and these effects will be modulated by whether or not subjects receive iTBS when they are engaged in a cognitive control task. Demonstrating this interaction between iTBS and mental state will lay critical groundwork for future studies to show how controlling mental state during TMS can improve therapeutic effects. Trial Registration: Clinicaltrials.gov NCT04010461.

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“…Although the heterogeneity was significant in their analysis (I 2 = 71.4% and P = 0.01 for the χ 2 test), the exclusion of the study with significant heterogeneity did not significantly change the effect size significant impact on the results. [84] They concluded that active rTMS was more effective than the sham stimulation in reducing the PTSD symptoms.…”

Section: Ptsdmentioning

confidence: 99%

Untitled

Rashidi

2017

AJP

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Psychiatric disorders are the most common debilitating diseases worldwide. Repetitive transcranial magnetic stimulation (rTMS) has shown therapeutic outcomes in different neurophysiology and neuropsychiatric disorders. Despite controversial findings on the therapeutic outcomes of this technique in different psychiatric disorders, researchers emphasize on developing this technique as an alternative or adjunctive modality for these disorders. Depression, different hallucinations, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and substance abuse are the main disorders have shown good treatment response to rTMS. This study aims to comprehensively overview the applications and recent advances in rTMS applications in psychiatric disorders. The databases of PubMed (1985PubMed ( -2017, Web of Sciences (1985-2017, Embase (1985-2017), Cochrane Central Library (1985-2017), and Google Scholar (1985-2017 were searched using the keywords of repetitive transcranial magnetic stimulation OR rTMS AND psychiatric disorders AND treatment. The retrieved records were reviewed, and the relevant studies were selected for further review. Repeated sessions of low frequency (≤5 Hz) rTMS induce long-lasting neural inhibition or depotentiation, whereas high frequency (>5 Hz) induces long-lasting neural excitability or potentiation. Depending on the neural alteration induced by a disorder, low-or high-frequency rTMS is used for the treatment. The rTMS is approved as acute treatment for major depression. The other diseases with promising outcomes are different hallucinations, OCD, and PTSD. rTMS seems to be an alternative or adjunctive therapeutic modality in different psychiatric disorders. To reach efficient clinical application for each disorder, further randomized clinical trials, as well as preclinical studies, are needed.

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Transcranial magnetic stimulation for posttraumatic stress disorder: an updated systematic review and meta-analysis

Abstract: Active TMS was superior to sham stimulation for amelioration of PTSD symptoms. Further RCTs with larger sample sizes are fundamental to clarify the precise impact of TMS in PTSD.

Cited by 49 publications

References 15 publications

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open‐label case series

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open‐label case series

Theta Burst Transcranial Magnetic Stimulation of Fronto-Parietal Networks: Modulation by Mental State

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