Effect of chlorhexidine varnish on gingival growth in orthodontic patients: a randomized prospective split-mouth study

Abstract

Introduction: Fixed orthodontic appliances patients suffer limitations on the effective control of biofilm by mechanical methods, bringing the need of a coadjutant in the control of inflammation and oral health improvement. Objective: The aim of this prospective split-mouth blind study was to analyze the effect of a 40% chlorhexidine (CHX) varnish on gingival growth of patients with orthodontic fixed appliances. Methods: Healthy teenage patients with fixed orthodontic appliances and increased gingival volume were recruited (n = 30). Each individual was his own control, having in the maxilla one control side and one treatment side. An application of varnishes occurred on the vestibular area of the upper premolars and first molar crowns, on the control side (placebo varnish) and on the experimental side (EC40(r) Biodentic CHX varnish). The varnishes and sides were randomly chosen and its identification and group was kept by a third party observer and it was not revealed to the researchers and participants until the end of study. In order to establish a baseline registration, digital photographs were taken by a trained photographer before varnish application at baseline (T0), as well as 14 days (T14) and 56 days (T56) after the application. The gingival volume was calculated indirectly using the vestibular areas (mm2) of the upper second premolars' clinical crowns by RapidSketch(r) software, at all study times. The data were analyzed using ANOVA and the Turkey-Krammer test. Results: It was observed, in the final sample of 30 individuals, that at T0, the control and treatment groups were similar. At T14 and T56, a progressive reduction of the clinical crown area was seen in the control group, and an increase in the average area was detected in the experimental group (p < 0,05). Conclusions: The use of 40% CHX varnish decreases the gingival overgrowth in patients undergoing orthodontic treatment. Further studies are necessary to set the action time and frequency of application.

Prevalence of gingival enlargement in patients with fixed orthodontic aparatology: A cross-sectional observational study.

“…A 2015 study in Brazil indicated that chlorhexidine varnish proved effective against gingival overgrowth in patients undergoing orthodontic treatment, recalling that chlorhexidine is considered the gold standard for the chemical control of dental biofilm [34]. In the present research, a reduction in the frequency of gingival enlargement was not found in those patients who referred to the use of chlorhexidine colloquia.…”

Influence of resin modified glass ionomer cement incorporating protein-repellent and antimicrobial agents on supragingival microbiome around brackets: an in-vivo split-mouth 3-month study

“…To better compare the influence of modified adhesive to unmodified material, we monitored the change of supragingival microbiome around the brackets bonded with either modified cement (RMD) or unmodified cement (RMGIC) via split-mouth performance to the same cohort. This design has been adopted in multiple studies relevant to oral hygiene or microbial change, which could lessen the individual variation of oral microbiome as much as possible ( Pellegrini et al, 2009 ; Pretti et al, 2015 ).…”

Gingivitis Effectiveness of Emulgel Containing 2% Resveratrol in Orthodontic Patients: An 8-Week Randomized Clinical Trial

“…The results showed that the use of 40% chlorhexidine varnish causes a gradual increase in the clinical crown at 14 and 56 days after use. Chlorhexidine varnish has been proved to be effective against gingival overgrowth in patients undergoing orthodontic treatment [ 30 ]. Biocompatibility of dental materials is an important consideration for the patient, clinician, laboratory technician, and manufacturer.…”