Aluminum Intoxication in Chronic Kidney Disease

Oliveira, Rodrigo Bueno de; Barreto, Fellype Carvalho; Nunes, Lucas Lobato Acatauassu; Custódio, Melani Ribeiro

doi:10.1590/2175-8239-jbn-2021-s110

Cited by 11 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14-16 The high proportion of bone Al accumulation, especially in the North and in the Northeast, suggests the need for reinforcing strategies to avoid Al exposure, as more rigorous limits for Al concentrations in water are used for dialysis (< 3 µg/L). 17…”

Section: Discussionmentioning

confidence: 99%

Overview of Renal Osteodystrophy in Brazil: A Cross-Sectional Study

Carbonara

Roza

Reis

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Introduction: Epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross sectional studies provide essential information to improve care and health policies. The Brazilian Registry of Bone Biopsy (REBRABO) is a prospective, national multicenter cohort that aims to provide clinical information on ROD. Methods: From Aug/2015 to Dec/2021, clinical, demographic, laboratory and ROD information were included. Results: Data from 386 individuals were considered. Age was 52 (42 to 60) years; 198 (51%) were male; 315 (82%) were on hemodialysis; osteitis fibrosa (OF) [163 (42%)] and adynamic bone disease (ABD) [96 (25%)] were the most prevalent forms of ROD; 190 (49%) had the diagnosis of osteoporosis, 82 (56%) vascular calcification; 138 (36%) bone aluminum accumulation and 137 (36%) iron intoxication; patients with high turnover were prone to present a higher prevalence of symptoms. Conclusions: Elevated proportion of patients were diagnosed with OF and ABD, as well as osteoporosis, vascular calcification and clinical symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Overview of Renal Osteodystrophy in Brazil: A Cross-Sectional Study

Carbonara

Roza

Reis

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…One of the main sources of exposure to aluminum in hemodialysis patients is hemodialysis fluid. 23 The high concentration of aluminum in the dialysis water can be attributed to the corrosion of the metal pipe system, its release from various synthetic materials such as polyethylene, and then the passage of a part of the aluminum ions through the reverse osmosis system. 19 Other studies are consistent with the results obtained in the present study about aluminum.…”

Section: Discussionmentioning

confidence: 99%

“…21 Aluminum accumulation is also associated with dementia syndrome and anemia, encephalopathy and osteodystrophy. 21 - 23 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Some Chemical Parameters of Hemodialysis Water: A Case Study in Iran

Naderi

Attar

Mohammadi

2022

Environ�Health�Insights

View full text Add to dashboard Cite

Background: One of the most common diseases in the world is kidney failure, which can lead to the death of patients. Hemodialysis is a treatment for patients whose kidneys are failing. The water used to perform dialysis must be healthy, safe, and clean. This study aimed to investigate the concentration of heavy metals in hemodialysis water in one of the Hospitals in Iran and compare it with European Pharmacopeia (EPH) and Association for the Advancement of Medical Instrumentation (AAMI) standards. Methods: The present study is a descriptive-analytical study conducted on the inlet water of hemodialysis machines in hospital. The samples were collected for 3 months from June to September 2021, Which was examined in terms of free residual chlorine, electrical conductivity, pH, and calcium, magnesium, sodium, aluminum, zinc, copper, and lead concentration. Metals concentration in hemodialysis water was measured by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) technique. Results: The average value of parameters such as electrical conductivity, pH, residual free chlorine, sodium, calcium, magnesium, zinc, copper and lead in the hemodialysis water was less than the AAMI and EPH standards limits. There was a significant difference at the 95% confidence level with the standard limits, but the aluminum concentration was higher than the standard limits. Also, by examining the medical files of dialysis patients, the most observed problems were anemia and bone diseases, which are probably caused by exposure to high concentrations of aluminum in hemodialysis water. Conclusion: In present study the aluminum concentration is higher than the standard limits. Considering that the higher aluminum concentration can cause diseases such as anemia, bone diseases, nervous deterioration, and death in hemodialysis patients, therefore, it is recommended to continuously evaluate and monitor the quality of hemodialysis water and the performance of its treatment system.

show abstract

“…Moreover, Se supplementation in chronic inflammation restores depleted hepatic and serum levels by increasing selenoprotein biosynthesis, leading to suppressed C-reactive protein production and attenuating the inflammatory process ( 134 ). The toxic effects of aluminum in patients with advanced CKD are expressed by severe encephalopathy and bone disease ( 135 ), and experiment on mice found Se-rich yeast (SeY) prevented renal toxicity caused by aluminum via regulation of inflammatory responses, ATPase activities, and transcription of their subunits ( 136 ). DNA damage in white blood cells is higher in CKD patients on HD than in healthy controls, and Se supplementation prevents the damage to DNA ( 137 ).…”

Section: Discussionmentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background and Objective: Chronic kidney disease (CKD) is an important public health concern.With the decline of renal function, CKD patients gradually progress to end-stage kidney disease and need to undergo dialysis or kidney transplantation to maintain life, bringing a heavy economic burden to the family and society. Therefore, it is necessary to effectively prevent and delay the progression of CKD. Essential trace elements play an indispensable role in CKD, and the objective of this study is to systematically review their benefits in the disease and summarize the risks of their excess.Methods: The keywords "trace elements", "chronic kidney disease", "dialysis", "inflammation", and "fibrosis" and their combinations were used to search for relevant literature published in the PubMed database and Web of Science. We then summarized the role of trace element abnormalities in CKD patients in anemia, oxidative stress, inflammation, and chronic fibrosis, and the risk of their excess.

show abstract

Aluminum Intoxication in Chronic Kidney Disease

Cited by 11 publications

References 41 publications

Overview of Renal Osteodystrophy in Brazil: A Cross-Sectional Study

Overview of Renal Osteodystrophy in Brazil: A Cross-Sectional Study

Evaluation of Some Chemical Parameters of Hemodialysis Water: A Case Study in Iran

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Contact Info

Product

Resources

About