Overview of Renal Osteodystrophy in Brazil: A Cross-Sectional Study

Abstract

Introduction: Epidemiologic profile of renal osteodystrophy (ROD) is changing over time and cross sectional studies provide essential information to improve care and health policies. The Brazilian Registry of Bone Biopsy (REBRABO) is a prospective, national multicenter cohort that aims to provide clinical information on ROD. Methods: From Aug/2015 to Dec/2021, clinical, demographic, laboratory and ROD information were included. Results: Data from 386 individuals were considered. Age was 52 (42 to 60) years; 198 (51%) were male; 315 (82%) were on hemodialysis; osteitis fibrosa (OF) [163 (42%)] and adynamic bone disease (ABD) [96 (25%)] were the most prevalent forms of ROD; 190 (49%) had the diagnosis of osteoporosis, 82 (56%) vascular calcification; 138 (36%) bone aluminum accumulation and 137 (36%) iron intoxication; patients with high turnover were prone to present a higher prevalence of symptoms. Conclusions: Elevated proportion of patients were diagnosed with OF and ABD, as well as osteoporosis, vascular calcification and clinical symptoms.

Renal osteodystrophy and clinical outcomes: a prospective cohort study

“…; p = 0.03] and presented lower serum hemoglobin levels [11.5 (10-13) vs. 12.2 (10. 7 Different models of Cox regression analysis with OF, MUO, ABD, OM, or bone TMV parameters did not reveal ROD as an independent predictor of hospitalization, MACE, or death (Figure 1).…”

“…This study was conducted as a subanalysis of the REBRABO data 5 , and is related in part to previously published data 4,[6][7][8] . The detailed methodology has been described elsewhere [4][5][6][7][8] . Briefly, the REBRABO is a prospective cohort of patients with ROD.…”

Osteodistrofia renal e desfechos clínicos: um estudo de coorte prospectivo

“…Este estudo foi realizado como uma subanálise dos dados do REBRABO 5 , e está relacionado, em parte, a dados publicados anteriormente 4,[6][7][8] . A metodologia detalhada foi descrita em outra publicação [4][5][6][7][8] . Em resumo, o REBRABO é uma coorte prospectiva de pacientes com OR.…”

Bone aluminum accumulation in the current era

“…However, in the last few years, contrasting evidence from the Brazilian Registry of Bone Biopsy (REBRABO) has pointed out a high incidence of Al accumulation in the bones of patients with CKD 5,6 . Clinical outcome data from this registry suggest that the presence of this metal in bone is not only an isolated histological finding.…”