The effects of obesity on kidney function: a challenge for nephrologists

Koch, Vera H.

doi:10.1590/2175-8239-jbn-2019-0064

Cited by 11 publications

(7 citation statements)

References 39 publications

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“…Overweight plus obesity are linked with hemodynamic structural in addition to histopathological modification in the kidney, with metabolic and biochemical changes that prompt to illness even when kidney function is ordinary in the conventional checks [13]. Obesity leads to the creation of adipokines which activate the beginning of inflammation, oxidative stress, unusual lipid metabolism, initiation of the rennin-angiotensin-aldosterone system and insulin resistance, these conditions cause ectopic lipid accumulation in kidney tissue, result in functional with structural morbidness of mesangial cells and the proximal tubule culminating with glumerular hypertension, elevated glumerular permeability, hyperfiltration, glomerulomegaly with albuminuria [14].…”

Section: Resultsmentioning

confidence: 99%

Effect of obesity on liver and kidney function in a sample from Ramadi city

2019

JAUS

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Obesity is one of the main metabolic disorder in Iraq and overall the world so the aim of the study was to assess the effect of obesity on renal function using serum creatinine, urea and uric acid tests and on hepatic function using serum aspartate aminotransferase (AST) , serum alanine aminotransferase (ALT) and bilirubin test. A total of 176 individuals were randomly selected from Ramadi city in this study and they were categorized into three sets in relation to their BMI. Set I obese, BMI ≥ 30 (n=61), set II overweight , BMI 25.0 to 29.9 (n=55) and set III Normal, BMI 18.5 to 24.9 (n=51), serum creatinine, urea, uric acid, ALT, AST and bilirubin were measured using commercially available kits, the results show that serum creatinine, urea, uric acid, ALT and AST were significantly higher in obese compared to overweight and normal sets (p<0.001).Obesity increase the risk for having renal and hepatic disease. Controlling obesity is necessary for protection liver and kidney health.

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Section: Resultsmentioning

confidence: 99%

Effect of obesity on liver and kidney function in a sample from Ramadi city

2019

JAUS

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“…Aponta-se a obesidade como uma doença crônica causada por múltiplos fatores, com risco de evoluir para outras doenças crônicas. Com ela, há o aumento da prevalência de HAS, DM, doenças cardiovasculares e dislipidemias (28,29) . Além disso, pessoas que tiveram sobrepeso em fases precoces da vida ou adquiriram obesidade na adolescência apresentam um maior risco de evoluir para a DRC na fase adulta (30) .…”

Section: Discussionunclassified

Fatores potenciais para desenvolvimento de doença renal em adolescentes e jovens: revisão integrativa/ Potential factors for the development of kidney disease in adolescents and young people: integrative review

Siqueira¹,

Ribeiro²,

Neves³

2021

Cienc. Cuid. Saúde

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Objetivo: identificar evidências científicas acerca dos fatores potenciais para o desenvolvimento de doença renal crônica em adolescentes e jovens. Método: revisão integrativa, utilizando uma ficha de seleção para extração dos dados das pesquisas nas bases de dados: Literatura Latino Americana e do Caribe em Ciências da Saúde, National Library of Medicine e Web Of Science, acessada via portal Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, no período de agosto de 2021, o que incluiu 12 artigos. A análise dos resultados da revisão ocorreu a partir da síntese de cada estudo primário. Resultados: as evidências científicas apontaram, como fatores potenciais para o desenvolvimento de doença renal crônica em adolescentes e jovens, as doenças crônicas, como diabetes, hipertensão, obesidade, e os fatores de risco, como uso de analgésicos, sobrepeso, baixo peso ao nascer e prematuridade. Conclusão: concluiu-se que é necessário um acompanhamento, a partir de estratégias coletivas ou individuais de educação em saúde, desses adolescentes, jovens e suas famílias, pois as doenças crônicas e fatores de risco podem ser prevenidos ou controlados.

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“…Compensatory glomerular hyperfiltration is considered an early sign of glomerular disease in obesity and thus plays a central role in obesity-induced CKD [4,5]. In the long-term though, individuals with a body mass index (BMI) greater than 30 kg/m 2 have a significant higher risk of glomerular filtration rate decline [6]. The most prevalent obesity-related comorbidities promoting renal injury are systemic hypertension and Type 2 diabetes (T2D) which can lead to diabetic nephropathy and hypertensive nephrosclerosis [1,7].…”

Section: Introductionmentioning

confidence: 99%

Bariatric Surgery Is Protective Against Renal Function Decline in Severely Obese Patients in the Long-Term

et al. 2020

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Purpose This study aims to assess the long-term renal effects of bariatric surgery (BS) in severely obese patients over a follow-up period of up to 11 years. Materials and Methods In a retrospective cohort study including 102 patients, patients were stratified by eGFR at baseline and divided into three groups: (1) reduced, (2) normal, and (3) increased filtration rate. Adjustments for age- and sex-related decline in eGFR were performed. We used uni- and multivariate regression analysis to identify variables that were thought to determine change in eGFR. Results Over a median follow-up of 8.5 years (interquartile range 2.7), eGFR declined from 96.1 ± 20.7 to 84.9 ± 21.0 ml/min (p < 0.001). Among patients with (1), eGFR remained stable (69.1 ± 19.3 ml/min). Among patients with (2), eGFR declined from 99.7 ± 13.3 ml/min to 88.7 ± 19.4 ml/min (p < 0.001). Among patients with (3), eGFR decreased to normal levels (94.2 ± 17.7 ml/min, p < 0.001). Age- and sex-adjusted eGFR increased (6.4 ± 14.4 ml/min; p < 0.05) among patients with reduced filtration rate. Among patients with normal filtration rate, adjusted eGFR remained stable during follow-up (−1.3 ± 15.2 ml/min; n.s.). Among patients with increased filtration rate, adjusted eGFR decreased and remained within the normal range (−13.2 ± 12.2 ml/min; p < 0.001). Change in eGFR showed a negative correlation with eGFR at baseline (B = −0.31; p < 0.001), change in LDL-cholesterol (B = -0.09; p < 0.05), and a negative correlation with treatment requiring hypertension (B = -9.36; p = 0.001). Conclusion BS is protective against renal function decline in severely obese patients in the long term.

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The effects of obesity on kidney function: a challenge for nephrologists

Abstract: The effects of obesity on kidney function: a challenge for nephrologists Efeitos renais da obesidade: um desafio para o nefrologista

Cited by 11 publications

References 39 publications

Effect of obesity on liver and kidney function in a sample from Ramadi city

Effect of obesity on liver and kidney function in a sample from Ramadi city

Fatores potenciais para desenvolvimento de doença renal em adolescentes e jovens: revisão integrativa/ Potential factors for the development of kidney disease in adolescents and young people: integrative review

Bariatric Surgery Is Protective Against Renal Function Decline in Severely Obese Patients in the Long-Term

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