Health surveillance and development of children with congenital Zika Virus syndrome: an integrative literature review

Abstract

Objective: To identify scientific knowledge about the attention to health surveillance and development of Brazilian children under the age of three years involving the Congenital Zika virus (ZIKV) Syndrome. Data sources: This is an integrative literature review of primary studies with Brazilian children under three years of age from 2015 to 2019. The searches were carried out in the databases Latin American and Caribbean Literature in Health Sciences (LILACS), US National Library of Medicine (PubMed), Cumulative Index to Nursing and Allied Health Literature (CINAHL), SCOPUS and Web of Science. It was carried out by crossing the keywords in English (child, child development and Zika virus) and in Portuguese (criança, desenvolvimento infantil e Zika vírus), with the combination of the Boolean operator “AND”. Data synthesis: The knowledge produced is related to the specific health and development problems of children affected by the Congenital ZIKV Syndrome, with clinical characteristics, care demands, multiprofessional performance, health monitoring and surveillance needs. Conclusions: This integrative review synthesized scientific knowledge by adding aspects that reinforce the relevance of appropriate approaches to assess and care for children, linked to the engagement of caregivers, the need to document, evaluate and track the situations of children in early childhood and long-term, management coordination of care and its challenges in the context of primary health care.

Disruption of myelin structure and oligodendrocyte maturation in a pigtail macaque model of congenital Zika infection

“…Zika virus (ZikV) is an emerging flavivirus that can be vertically transmitted to the fetus from an infected pregnant mother, leading to congenital Zika syndrome (CZS), which encompasses a range of fetal malformations including hearing loss, ocular manifestations, intrauterine growth restriction, and microcephaly 1–4 , as well as miscarriage 5–7 . CZS persists post-partum and imposes major complications to childhood development, now manifested across ZikV-endemic regions 8,9 . While the mechanism of microcephaly in CZS is thought to be related to ZikV infection and death of neural progenitor cells leading to decreased neurogenesis 10–12 , the pathogenesis of neurodevelopmental delay in CZS displaying normal brain development, termed “normocephalic”, is poorly understood.…”

“…Zika virus (ZikV) is an emerging flavivirus that can be vertically transmitted to the fetus from an infected pregnant mother, leading to congenital Zika syndrome (CZS), which encompasses a range of fetal malformations including hearing loss, ocular manifestations, intrauterine growth restriction, and microcephaly [1][2][3][4] , as well as miscarriage [5][6][7] . CZS persists post-partum and imposes major complications to childhood development, now manifested across ZikV-endemic regions 8,9 .…”